Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
ABSTRACT: The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher...
- Autores:
-
Aguilar Jiménez, Wbeimar
Zapata Builes, Wildeman
Rugeles López, María Teresa
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/36573
- Acceso en línea:
- https://hdl.handle.net/10495/36573
- Palabra clave:
- VIH-1
HIV-1
Antivirales
Antiviral Agents
Vitamina D
Vitamin D
Exposición a Riesgos Ambientales
Environmental Exposure
Perfilación de la Expresión Génica
Gene Expression Profiling
Persona de Mediana Edad
Middle Aged
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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| dc.title.spa.fl_str_mv |
Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection |
| title |
Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection |
| spellingShingle |
Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection VIH-1 HIV-1 Antivirales Antiviral Agents Vitamina D Vitamin D Exposición a Riesgos Ambientales Environmental Exposure Perfilación de la Expresión Génica Gene Expression Profiling Persona de Mediana Edad Middle Aged |
| title_short |
Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection |
| title_full |
Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection |
| title_fullStr |
Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection |
| title_full_unstemmed |
Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection |
| title_sort |
Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection |
| dc.creator.fl_str_mv |
Aguilar Jiménez, Wbeimar Zapata Builes, Wildeman Rugeles López, María Teresa |
| dc.contributor.author.none.fl_str_mv |
Aguilar Jiménez, Wbeimar Zapata Builes, Wildeman Rugeles López, María Teresa |
| dc.contributor.researchgroup.spa.fl_str_mv |
Inmunovirología |
| dc.subject.decs.none.fl_str_mv |
VIH-1 HIV-1 Antivirales Antiviral Agents Vitamina D Vitamin D Exposición a Riesgos Ambientales Environmental Exposure Perfilación de la Expresión Génica Gene Expression Profiling Persona de Mediana Edad Middle Aged |
| topic |
VIH-1 HIV-1 Antivirales Antiviral Agents Vitamina D Vitamin D Exposición a Riesgos Ambientales Environmental Exposure Perfilación de la Expresión Génica Gene Expression Profiling Persona de Mediana Edad Middle Aged |
| description |
ABSTRACT: The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1. |
| publishDate |
2016 |
| dc.date.issued.none.fl_str_mv |
2016 |
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2023-09-06T16:43:21Z |
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2023-09-06T16:43:21Z |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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Aguilar-Jimenez W, Zapata W, Rugeles MT. Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection. Microbes Infect. 2016 Jul-Aug;18(7-8):510-6. Epub 2016 Apr 12. PMID: 27083474. |
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1286-4579 1769-714X |
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https://hdl.handle.net/10495/36573 |
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j.micinf.2016.03.015_ |
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Aguilar-Jimenez W, Zapata W, Rugeles MT. Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection. Microbes Infect. 2016 Jul-Aug;18(7-8):510-6. Epub 2016 Apr 12. PMID: 27083474. 1286-4579 1769-714X j.micinf.2016.03.015_ |
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https://hdl.handle.net/10495/36573 |
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eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Microbes Infect. |
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516 |
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7-8 |
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510 |
| dc.relation.citationvolume.spa.fl_str_mv |
18 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Microbes and Infection |
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http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
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openAccess |
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Aguilar Jiménez, WbeimarZapata Builes, WildemanRugeles López, María TeresaInmunovirología2023-09-06T16:43:21Z2023-09-06T16:43:21Z2016Aguilar-Jimenez W, Zapata W, Rugeles MT. Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection. Microbes Infect. 2016 Jul-Aug;18(7-8):510-6. Epub 2016 Apr 12. PMID: 27083474.1286-45791769-714Xhttps://hdl.handle.net/10495/36573j.micinf.2016.03.015_ABSTRACT: The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheral-blood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1.COL00124447application/pdfengElsevierParís, Franciahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infectionArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionVIH-1HIV-1AntiviralesAntiviral AgentsVitamina DVitamin DExposición a Riesgos AmbientalesEnvironmental ExposurePerfilación de la Expresión GénicaGene Expression ProfilingPersona de Mediana EdadMiddle AgedMicrobes Infect.5167-851018Microbes and InfectionPublicationORIGINALAguilarWbeimar_2016_AntiviralMoleculesCorrelateVitaminD (1).pdfAguilarWbeimar_2016_AntiviralMoleculesCorrelateVitaminD (1).pdfArtículo de Investigaciónapplication/pdf876609https://bibliotecadigital.udea.edu.co/bitstreams/6c9f8d73-4192-418b-b31a-bc27543fd055/download3865bc465545a68ed95913396202641dMD51trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; 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