Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia
ABSTRACT: The present study was undertaken to examine the pattern of inheritance of Ceft Lip/Palate (CLP) in pedigrees ascertained from Antioquia, Colombia. Ninety-five extended and multigenerational pedigrees, constituted by 201 nuclear components and 1.136 records were analyzed. Ten hypothetical m...
- Autores:
-
Moreno Uribe, Lina María
Lidral, Andrew
Fonseca González, Idalyd
Arcos Burgos, Oscar Mauricio
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2001
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/20918
- Acceso en línea:
- http://hdl.handle.net/10495/20918
https://revistas.udea.edu.co/index.php/actbio/article/view/329618
- Palabra clave:
- Fisura del Paladar
Cleft Palate
Genética
Genetics
Anomalías de la Boca
Mouth Abnormalities
Grupos Étnicos
Ethnic Groups
Genética Humana
Human Genetics
Antioquia (Colombia)
Labio leporino
Harelip
Labio hendido
Cleft lip
Paladar hendido
Cleft palate
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/2.5/co/
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| dc.title.spa.fl_str_mv |
Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia |
| dc.title.translated.spa.fl_str_mv |
Análisis de segregación compleja de labio/paladar hendido no sindrómico en Antioquia, Colombia |
| title |
Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia |
| spellingShingle |
Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia Fisura del Paladar Cleft Palate Genética Genetics Anomalías de la Boca Mouth Abnormalities Grupos Étnicos Ethnic Groups Genética Humana Human Genetics Antioquia (Colombia) Labio leporino Harelip Labio hendido Cleft lip Paladar hendido Cleft palate |
| title_short |
Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia |
| title_full |
Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia |
| title_fullStr |
Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia |
| title_full_unstemmed |
Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia |
| title_sort |
Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia |
| dc.creator.fl_str_mv |
Moreno Uribe, Lina María Lidral, Andrew Fonseca González, Idalyd Arcos Burgos, Oscar Mauricio |
| dc.contributor.author.none.fl_str_mv |
Moreno Uribe, Lina María Lidral, Andrew Fonseca González, Idalyd Arcos Burgos, Oscar Mauricio |
| dc.contributor.researchgroup.spa.fl_str_mv |
Genética Regeneración y Cáncer |
| dc.subject.decs.none.fl_str_mv |
Fisura del Paladar Cleft Palate Genética Genetics Anomalías de la Boca Mouth Abnormalities Grupos Étnicos Ethnic Groups Genética Humana Human Genetics |
| topic |
Fisura del Paladar Cleft Palate Genética Genetics Anomalías de la Boca Mouth Abnormalities Grupos Étnicos Ethnic Groups Genética Humana Human Genetics Antioquia (Colombia) Labio leporino Harelip Labio hendido Cleft lip Paladar hendido Cleft palate |
| dc.subject.lemb.none.fl_str_mv |
Antioquia (Colombia) Labio leporino Harelip Labio hendido Cleft lip Paladar hendido Cleft palate |
| description |
ABSTRACT: The present study was undertaken to examine the pattern of inheritance of Ceft Lip/Palate (CLP) in pedigrees ascertained from Antioquia, Colombia. Ninety-five extended and multigenerational pedigrees, constituted by 201 nuclear components and 1.136 records were analyzed. Ten hypothetical models were contrasted using likelihood ratio tests. The hypotheses of no familial transmission, multifactorial component compared against that of the existence of a major gene only, the existence of a recessive major gene, that of non major component in the mixed model and that of the non transmission of major effect (t1 = 12 = (3) were rejected. In contrast. hypotheses postulating a major locus (dominant, codominant) and that of no polygenic component in the mixed model could not be rejected. Iteration of the parameter 12 was the most parsimonious. Thus far, the most parsimonious model is that of a major gene (dominant-codominant) without multifactorial effects but, taking into account, that the (2 iteration in the major gene model with unrestricted d. result in a significantly improving of the model likelihood, oligogenic interactions can not be underrated. |
| publishDate |
2001 |
| dc.date.issued.none.fl_str_mv |
2001 |
| dc.date.accessioned.none.fl_str_mv |
2021-07-16T16:33:44Z |
| dc.date.available.none.fl_str_mv |
2021-07-16T16:33:44Z |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Moreno, L., Lidral, A., Fonseca, I., Valencia C., & Arcos, M. (2001). Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia. Actualidades Biológicas, 23(74), 49-56. https://revistas.udea.edu.co/index.php/actbio/article/view/329618 |
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0304-3584 |
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http://hdl.handle.net/10495/20918 |
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2145-7166 |
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https://revistas.udea.edu.co/index.php/actbio/article/view/329618 |
| identifier_str_mv |
Moreno, L., Lidral, A., Fonseca, I., Valencia C., & Arcos, M. (2001). Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia. Actualidades Biológicas, 23(74), 49-56. https://revistas.udea.edu.co/index.php/actbio/article/view/329618 0304-3584 2145-7166 |
| url |
http://hdl.handle.net/10495/20918 https://revistas.udea.edu.co/index.php/actbio/article/view/329618 |
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eng |
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eng |
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Actual. Biol. |
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56 |
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74 |
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49 |
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23 |
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Actualidades Biológicas |
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http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
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Universidad de Antioquia, Facultad de Ciencias Exactas y Naturales, Instituto de Biología |
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Medellín, Colombia |
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Universidad de Antioquia |
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Moreno Uribe, Lina MaríaLidral, AndrewFonseca González, IdalydArcos Burgos, Oscar MauricioGenética Regeneración y Cáncer2021-07-16T16:33:44Z2021-07-16T16:33:44Z2001Moreno, L., Lidral, A., Fonseca, I., Valencia C., & Arcos, M. (2001). Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, Colombia. Actualidades Biológicas, 23(74), 49-56. https://revistas.udea.edu.co/index.php/actbio/article/view/3296180304-3584http://hdl.handle.net/10495/209182145-7166https://revistas.udea.edu.co/index.php/actbio/article/view/329618ABSTRACT: The present study was undertaken to examine the pattern of inheritance of Ceft Lip/Palate (CLP) in pedigrees ascertained from Antioquia, Colombia. Ninety-five extended and multigenerational pedigrees, constituted by 201 nuclear components and 1.136 records were analyzed. Ten hypothetical models were contrasted using likelihood ratio tests. The hypotheses of no familial transmission, multifactorial component compared against that of the existence of a major gene only, the existence of a recessive major gene, that of non major component in the mixed model and that of the non transmission of major effect (t1 = 12 = (3) were rejected. In contrast. hypotheses postulating a major locus (dominant, codominant) and that of no polygenic component in the mixed model could not be rejected. Iteration of the parameter 12 was the most parsimonious. Thus far, the most parsimonious model is that of a major gene (dominant-codominant) without multifactorial effects but, taking into account, that the (2 iteration in the major gene model with unrestricted d. result in a significantly improving of the model likelihood, oligogenic interactions can not be underrated.RESUMEN: El presente estudio fue realizado para evaluar el patrón hereditario de Labio/Paladar Hendido (CLP) en genealogías estudiadas en el departamento de Antioquia, Colombia. Se analizaron 95 genealogías multigeneracionales extendidas. constituidas por 201 componentes nucleares y 1.136 individuos. Se contrastaron diez modelos hipotéticos mediante el test de verosimilitud. Las hipótesis de no-transmisión familiar y el componente multifactorial, comparadas contra la hipótesis de existencia de un gen mayor y de un gen mayor recesivo, y la no existencia del componente mayor en el modelo mixto y no transmisión de efectos mayores (11-12-13), fueron refutadas. En contraste, no pudieron refutarse las hipótesis que postulan un locus mayor (dominante, codominante) y un componente no poligénico en el modelo mixto. El modelo más parsimonioso fue el de gen mayor (dominante-codominante) sin efectos multifactoriales tomando en cuenta la iteración del parámetro 12 con d no restringido, lo que resultó en un mejoramiento significativo del valor de verosimilitud en este modelo. Las interacciones oligogénicas no pueden ser subestimadas.COL00067697application/pdfengUniversidad de Antioquia, Facultad de Ciencias Exactas y Naturales, Instituto de BiologíaMedellín, Colombiahttp://creativecommons.org/licenses/by-nc-sa/2.5/co/https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Complex segregation analysis of nonsyndromic Cleft Lip/Palate in Antioquia, ColombiaAnálisis de segregación compleja de labio/paladar hendido no sindrómico en Antioquia, ColombiaArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionFisura del PaladarCleft PalateGenéticaGeneticsAnomalías de la BocaMouth AbnormalitiesGrupos ÉtnicosEthnic GroupsGenética HumanaHuman GeneticsAntioquia (Colombia)Labio leporinoHarelipLabio hendidoCleft lipPaladar hendidoCleft palateActual. 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