Leishmanicidal Activity of Aliphatic and Aromatic Lactones : Correlation Structure-Activity
ABSTRACT: Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance o...
- Autores:
-
Castaño Gil, Yenni Marcela
Cardona Galeano, Wilson
Quiñones Fletcher, Winston
Robledo Restrepo, Sara María
Echeverrí López, Luis Fernando
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2009
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/23676
- Acceso en línea:
- http://hdl.handle.net/10495/23676
- Palabra clave:
- Fonética
Phonetics
Antiparasitarios
Antiparasitic Agents
Lactones
Lactonas
Leishmaniosis
Leishmaniosis
Metátesis
http://aims.fao.org/aos/agrovoc/c_4145
http://aims.fao.org/aos/agrovoc/c_35197
http://id.loc.gov/authorities/subjects/sh85084301
https://id.nlm.nih.gov/mesh/D000977
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/4.0/
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| dc.title.spa.fl_str_mv |
Leishmanicidal Activity of Aliphatic and Aromatic Lactones : Correlation Structure-Activity |
| title |
Leishmanicidal Activity of Aliphatic and Aromatic Lactones : Correlation Structure-Activity |
| spellingShingle |
Leishmanicidal Activity of Aliphatic and Aromatic Lactones : Correlation Structure-Activity Fonética Phonetics Antiparasitarios Antiparasitic Agents Lactones Lactonas Leishmaniosis Leishmaniosis Metátesis http://aims.fao.org/aos/agrovoc/c_4145 http://aims.fao.org/aos/agrovoc/c_35197 http://id.loc.gov/authorities/subjects/sh85084301 https://id.nlm.nih.gov/mesh/D000977 |
| title_short |
Leishmanicidal Activity of Aliphatic and Aromatic Lactones : Correlation Structure-Activity |
| title_full |
Leishmanicidal Activity of Aliphatic and Aromatic Lactones : Correlation Structure-Activity |
| title_fullStr |
Leishmanicidal Activity of Aliphatic and Aromatic Lactones : Correlation Structure-Activity |
| title_full_unstemmed |
Leishmanicidal Activity of Aliphatic and Aromatic Lactones : Correlation Structure-Activity |
| title_sort |
Leishmanicidal Activity of Aliphatic and Aromatic Lactones : Correlation Structure-Activity |
| dc.creator.fl_str_mv |
Castaño Gil, Yenni Marcela Cardona Galeano, Wilson Quiñones Fletcher, Winston Robledo Restrepo, Sara María Echeverrí López, Luis Fernando |
| dc.contributor.author.none.fl_str_mv |
Castaño Gil, Yenni Marcela Cardona Galeano, Wilson Quiñones Fletcher, Winston Robledo Restrepo, Sara María Echeverrí López, Luis Fernando |
| dc.contributor.researchgroup.spa.fl_str_mv |
Programa de Estudio y Control de Enfermedades Tropicales (PECET) Química de Plantas Colombianas Química Orgánica de Productos Naturales |
| dc.subject.decs.none.fl_str_mv |
Fonética Phonetics Antiparasitarios Antiparasitic Agents |
| topic |
Fonética Phonetics Antiparasitarios Antiparasitic Agents Lactones Lactonas Leishmaniosis Leishmaniosis Metátesis http://aims.fao.org/aos/agrovoc/c_4145 http://aims.fao.org/aos/agrovoc/c_35197 http://id.loc.gov/authorities/subjects/sh85084301 https://id.nlm.nih.gov/mesh/D000977 |
| dc.subject.agrovoc.none.fl_str_mv |
Lactones Lactonas Leishmaniosis Leishmaniosis |
| dc.subject.proposal.spa.fl_str_mv |
Metátesis |
| dc.subject.agrovocuri.none.fl_str_mv |
http://aims.fao.org/aos/agrovoc/c_4145 http://aims.fao.org/aos/agrovoc/c_35197 |
| dc.subject.lcshuri.none.fl_str_mv |
http://id.loc.gov/authorities/subjects/sh85084301 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D000977 |
| description |
ABSTRACT: Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance of the aliphatic side chain to enhance the biological activity and to obtain lower cytotoxicity. It was also observed that a decrease in the size of the lactone ring increases the selectivity index. |
| publishDate |
2009 |
| dc.date.issued.none.fl_str_mv |
2009 |
| dc.date.accessioned.none.fl_str_mv |
2021-11-01T18:45:00Z |
| dc.date.available.none.fl_str_mv |
2021-11-01T18:45:00Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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| dc.identifier.citation.spa.fl_str_mv |
Castaño, M., Cardona, W., Quiñones, W., Robledo, S., & Echeverri, F. (2009). Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity. Molecules, 14(7), 2491–2500. Retrieved from http://dx.doi.org/10.3390/molecules14072491 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/23676 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/molecules14072491 |
| dc.identifier.eissn.none.fl_str_mv |
1420-3049 |
| identifier_str_mv |
Castaño, M., Cardona, W., Quiñones, W., Robledo, S., & Echeverri, F. (2009). Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity. Molecules, 14(7), 2491–2500. Retrieved from http://dx.doi.org/10.3390/molecules14072491 10.3390/molecules14072491 1420-3049 |
| url |
http://hdl.handle.net/10495/23676 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Molecules |
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2500 |
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7 |
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2491 |
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14 |
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Molecules |
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Basilea, Suiza |
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Castaño Gil, Yenni MarcelaCardona Galeano, WilsonQuiñones Fletcher, WinstonRobledo Restrepo, Sara MaríaEcheverrí López, Luis FernandoPrograma de Estudio y Control de Enfermedades Tropicales (PECET)Química de Plantas ColombianasQuímica Orgánica de Productos Naturales2021-11-01T18:45:00Z2021-11-01T18:45:00Z2009Castaño, M., Cardona, W., Quiñones, W., Robledo, S., & Echeverri, F. (2009). Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity. Molecules, 14(7), 2491–2500. Retrieved from http://dx.doi.org/10.3390/molecules14072491http://hdl.handle.net/10495/2367610.3390/molecules140724911420-3049ABSTRACT: Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance of the aliphatic side chain to enhance the biological activity and to obtain lower cytotoxicity. 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