Leishmanicidal Activity of Aliphatic and Aromatic Lactones : Correlation Structure-Activity

ABSTRACT: Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis. The structure-activity relationship showed the importance of the aliphatic side chain to enhance the biological activity and to obtain lower cytotoxicity. It was also observed that a decrease in the size of the lactone ring increases the selectivity index.

• Autores: Castaño Gil, Yenni Marcela; Cardona Galeano, Wilson; Quiñones Fletcher, Winston; Robledo Restrepo, Sara María; Echeverrí López, Luis Fernando
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2009
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/23676
• Acceso en línea: http://hdl.handle.net/10495/23676
• Palabra clave: Fonética; Phonetics; Antiparasitarios; Antiparasitic Agents; Lactones; Lactonas; Leishmaniosis; Leishmaniosis; Metátesis; http://aims.fao.org/aos/agrovoc/c_4145; http://aims.fao.org/aos/agrovoc/c_35197; http://id.loc.gov/authorities/subjects/sh85084301; https://id.nlm.nih.gov/mesh/D000977
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/