The E280A Presenilin-1 Alzheimer mutation produces increased Aß42 depossition and severe cerebellar pathology

ABSTRACT: Missense mutations in the presenilin 1 (PS1) gene cause the most common form of dominant early–onset familial Alzheimer's disease (FAD)1,2 and are associated with increased levels of amyloid β–peptides (Aβ) ending at residue 42 (Aβ42) in plasma and skin fibroblast media of gene carrie...

Full description

Autores:

Lopera Restrepo, Francisco Javier
Ruiz Linares, Andrés
Ossa Londoño, Jorge Eliécer
Martínez, Alonso
Madrigal Zapata, Lucia del Socorro
Hincapié, Liliana
Arango Lasprilla, Juan Carlos
Arango Viana, Juan Carlos
Lemere, Cynthia A.
Kenneth S., Kosik
Corrine L, Lendon
Takaomi C., Saido
Haruyasu, Yamaguchi
Douglas C., Anthony
Edward H., Koo
Alison M., Goate
Dennis J., Selkoe

Tipo de recurso:

Article of investigation

Fecha de publicación:

1996

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/36529

Acceso en línea:

https://hdl.handle.net/10495/36529

Palabra clave:

Presenilina-1
Presenilin-1
Enfermedad de Alzheimer
Alzheimer Disease
Química Encefálica
Brain Chemistry
Proteínas del Tejido Nervioso
Nerve Tissue Proteins
Procesamiento de Imagen Asistido por Computador
Image Processing, Computer-Assisted
A beta 42

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/