Human papillomavirus is not associated with colorectal cancer in a large international study

ABSTRACT: Objective of the study: Recent publications have reported an association between colon cancer and human papillomaviruses (HPV), suggesting that HPV infection of the colonic mucosa may contribute to the development of colorectal cancer. Methods: The GP5+/GP6+ PCR reverse line blot method was used for detection of 37 types of human papillomavirus (HPV) in DNA from paraffin-embedded or frozen tissues from patients with colorectal cancer (n = 279) and normal adjacent tissue (n = 30) in three different study populations, including samples from the United States (n = 73), Israel (n = 106) and Spain (n = 100). Additionally, SPF10 PCR was run on all samples (n = 279) and the Innogenetics INNO-LiPA assay was performed on a subset of samples (n = 15). Results: All samples were negative for all types of HPV using both the GP5+/GP6+ PCR reverse line blot method and the SPF10 INNO-LiPA method. Conclusions: We conclude that HPV types associated with malignant transformation do not meaningfully contribute to adenocarcinoma of the colon.

• Autores: Sánchez Vásquez, Gloria; Castellsague, Xavier; Gornick, Michele C.; Giordano, Thomas J.; Vinco, Michelle; Greenson, Joel K.; Capella, Gabriel; Raskin, Leon; Rennert, Gad; Gruber, Stephen B.; Moreno, Víctor
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2010
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/39587
• Acceso en línea: https://hdl.handle.net/10495/39587
• Palabra clave: Adenocarcinoma; Adenocarcinoma; Virología; Virology; Alphapapillomavirus; Alphapapillomavirus; Estudios de Casos y Controles; Case-Control Studies; Transformación Celular Viral; Cell Transformation; Neoplasias Colorrectales; Colorectal Neoplasms; ADN Viral; DNA, viral; Reacción en Cadena de la Polimerasa; Polymerase Chain Reaction; Infecciones por Papillomavirus; Papillomavirus Infections; https://id.nlm.nih.gov/mesh/D000230; https://id.nlm.nih.gov/mesh/D014773; https://id.nlm.nih.gov/mesh/D052685; https://id.nlm.nih.gov/mesh/D016022; https://id.nlm.nih.gov/mesh/D002472; https://id.nlm.nih.gov/mesh/D015179; https://id.nlm.nih.gov/mesh/D004279; https://id.nlm.nih.gov/mesh/D016133; https://id.nlm.nih.gov/mesh/D030361
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/