Reproductive factors and molecular subtypes of breast cancer among premenopausal women in Latin America: the PRECAMA study

ABSTRACT: Etiological differences among breast cancer (BC) subtypes have not been clearly established, especially among young women in Latin America. This study examined the relationship between reproductive factors and BC subtypes among 288 BC cases (20–45 years) and population-based matched controls in four Latin American countries. Immunohistochemistry was determined centrally. Associations between BC and reproductive factors were determined. Older age at first full-term pregnancy (FFTP) (Odds Ratio (OR) = 1.11; 95% Confidence Interval (CI), 1.04–1.19 per year), longer time between menarche and FFTP (OR = 1.12; 95%CI: 1.04–1.20 per year), and older age at last pregnancy (OR = 1.10; 95%CI, 1.02–1.19 per year) were associated with an increased risk of estrogen receptor positive (ER+) tumors (n = 122). Ever pregnant (OR = 0.35; 95%CI, 0.13–0.96), number of childbirths (OR = 0.64; 95%CI, 0.47–0.87 per child), time since last birth (OR = 0.92; 95%CI, 0.85–0.99 per year), and history of breastfeeding (OR = 0.23; 95%CI, 0.09–0.58) were inversely associated with the risk of ER+ tumor. Older age at menarche (OR = 0.63; 95%CI, 0.45–0.89 per year) and longer duration of breastfeeding (OR = 0.97; 95%CI, 0.94–1.01 per month) were inversely associated with estrogen receptor negative (ER-) tumors (n = 48). Reproductive factors may be differentially associated with BC subtypes in young Latin American women.

• Autores: Sánchez Vásquez, Gloria; Biessy, Carine; Carayol, Marion; His, Mathilde; Torres Mejía, Gabriela; Ángeles Llerenas, Angélica; Jaramillo, Roberto; Navarro Lechuga, Edgar; Porras, Carolina; Ocampo, Rebecca; Rodríguez, Ana Cecilia; Garmendía, María Luisa; Bustamante, Eva; Olivier, Magali; Porter, Peggy; Rinaldi, Sabina; Romieu, Isabelle
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2018
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/36544
• Acceso en línea: https://hdl.handle.net/10495/36544
• Palabra clave: Neoplasias de la Mama; Breast Neoplasms; Estudios de Casos y Controles; Case-Control Studies; Intervalos de Confianza; Confidence Intervals; Oportunidad Relativa; Odds Ratio; Premenopausia; Premenopause; Factores de Riesgo; Risk Factors
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/