Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G
ABSTRACT: This is a case report of women with pregnancy morbidity (PM), some of them associated with antiphospholipid syndrome (APS), in which the glycan patterns of immunoglobulin G (IgG) were investigated based on the theory of alteration of glycosylation in autoimmunity. We used lectin blot to de...
- Autores:
-
Cadavid Jaramillo, Angela Patricia
Bueno Sánchez, Julio Cesar
Álvarez Gómez, Ángela María
Gómez Gutiérrez, Alejandra María
Rúa Molina, Diana Carolina
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2021
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/43638
- Acceso en línea:
- https://hdl.handle.net/10495/43638
http://bibpurl.oclc.org/web/38913
- Palabra clave:
- Anticuerpos Antifosfolípidos
Antibodies, Antiphospholipid
Síndrome Antifosfolípido
Antiphospholipid Syndrome
Glicosilación
Glycosylation
Inmunoglobulina G
Immunoglobulin G
Trombosis
Thrombosis
Complicaciones del Embarazo
Pregnancy Complications
Autoinmunidad
Autoimmunity
https://id.nlm.nih.gov/mesh/D017152
https://id.nlm.nih.gov/mesh/D016736
https://id.nlm.nih.gov/mesh/D006031
https://id.nlm.nih.gov/mesh/D007074
https://id.nlm.nih.gov/mesh/D013927
https://id.nlm.nih.gov/mesh/D011248
https://id.nlm.nih.gov/mesh/D015551
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/2.5/co/
| id |
UDEA2_de43fcd7de5f0818bbd4dd1ca7a82d22 |
|---|---|
| oai_identifier_str |
oai:bibliotecadigital.udea.edu.co:10495/43638 |
| network_acronym_str |
UDEA2 |
| network_name_str |
Repositorio UdeA |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G |
| title |
Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G |
| spellingShingle |
Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G Anticuerpos Antifosfolípidos Antibodies, Antiphospholipid Síndrome Antifosfolípido Antiphospholipid Syndrome Glicosilación Glycosylation Inmunoglobulina G Immunoglobulin G Trombosis Thrombosis Complicaciones del Embarazo Pregnancy Complications Autoinmunidad Autoimmunity https://id.nlm.nih.gov/mesh/D017152 https://id.nlm.nih.gov/mesh/D016736 https://id.nlm.nih.gov/mesh/D006031 https://id.nlm.nih.gov/mesh/D007074 https://id.nlm.nih.gov/mesh/D013927 https://id.nlm.nih.gov/mesh/D011248 https://id.nlm.nih.gov/mesh/D015551 |
| title_short |
Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G |
| title_full |
Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G |
| title_fullStr |
Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G |
| title_full_unstemmed |
Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G |
| title_sort |
Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G |
| dc.creator.fl_str_mv |
Cadavid Jaramillo, Angela Patricia Bueno Sánchez, Julio Cesar Álvarez Gómez, Ángela María Gómez Gutiérrez, Alejandra María Rúa Molina, Diana Carolina |
| dc.contributor.author.none.fl_str_mv |
Cadavid Jaramillo, Angela Patricia Bueno Sánchez, Julio Cesar Álvarez Gómez, Ángela María Gómez Gutiérrez, Alejandra María Rúa Molina, Diana Carolina |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Investigación en Trombosis Grupo Reproducción |
| dc.subject.decs.none.fl_str_mv |
Anticuerpos Antifosfolípidos Antibodies, Antiphospholipid Síndrome Antifosfolípido Antiphospholipid Syndrome Glicosilación Glycosylation Inmunoglobulina G Immunoglobulin G Trombosis Thrombosis Complicaciones del Embarazo Pregnancy Complications Autoinmunidad Autoimmunity |
| topic |
Anticuerpos Antifosfolípidos Antibodies, Antiphospholipid Síndrome Antifosfolípido Antiphospholipid Syndrome Glicosilación Glycosylation Inmunoglobulina G Immunoglobulin G Trombosis Thrombosis Complicaciones del Embarazo Pregnancy Complications Autoinmunidad Autoimmunity https://id.nlm.nih.gov/mesh/D017152 https://id.nlm.nih.gov/mesh/D016736 https://id.nlm.nih.gov/mesh/D006031 https://id.nlm.nih.gov/mesh/D007074 https://id.nlm.nih.gov/mesh/D013927 https://id.nlm.nih.gov/mesh/D011248 https://id.nlm.nih.gov/mesh/D015551 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D017152 https://id.nlm.nih.gov/mesh/D016736 https://id.nlm.nih.gov/mesh/D006031 https://id.nlm.nih.gov/mesh/D007074 https://id.nlm.nih.gov/mesh/D013927 https://id.nlm.nih.gov/mesh/D011248 https://id.nlm.nih.gov/mesh/D015551 |
| description |
ABSTRACT: This is a case report of women with pregnancy morbidity (PM), some of them associated with antiphospholipid syndrome (APS), in which the glycan patterns of immunoglobulin G (IgG) were investigated based on the theory of alteration of glycosylation in autoimmunity. We used lectin blot to determine changes in terminal glycosylation of polyclonal IgG from women with antiphospholipid (aPL) antibodies and PM plus vascular thrombosis (PM/VT) and seronegative-obstetric APS (SN-OAPS). In addition, we analyzed IgG from women with PM without aPL (PM/aPL-) and healthy women, as controls. Even though the SN-OAPS and PM/VT groups share the PM, only the SN-OAPS group showed a decreased expression of galactose compared to the healthy group. We also found the presence of mannosylated oligosaccharides in IgG from all patients being significantly higher in IgG from women of the PM/aPL- group. The differences in glycans presented here could relate to pathological mechanisms of PM associated with APS. |
| publishDate |
2021 |
| dc.date.issued.none.fl_str_mv |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2024-11-20T16:19:39Z |
| dc.date.available.none.fl_str_mv |
2024-11-20T16:19:39Z |
| dc.type.spa.fl_str_mv |
Reporte de caso |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ARTCASO |
| dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| status_str |
publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Alvarez AM, Gomez-Gutierrez AM, Bueno-Sánchez JC, Rúa-Molina C, Cadavid AP. Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G. J Hum Reprod Sci. 2021 Jan-Mar;14(1):97-100. doi: 10.4103/jhrs.JHRS_21_20. |
| dc.identifier.issn.none.fl_str_mv |
0974-1208 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/43638 |
| dc.identifier.doi.none.fl_str_mv |
10.4103/jhrs.JHRS_21_20 |
| dc.identifier.eissn.none.fl_str_mv |
1998-4766 |
| dc.identifier.url.spa.fl_str_mv |
http://bibpurl.oclc.org/web/38913 |
| identifier_str_mv |
Alvarez AM, Gomez-Gutierrez AM, Bueno-Sánchez JC, Rúa-Molina C, Cadavid AP. Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G. J Hum Reprod Sci. 2021 Jan-Mar;14(1):97-100. doi: 10.4103/jhrs.JHRS_21_20. 0974-1208 10.4103/jhrs.JHRS_21_20 1998-4766 |
| url |
https://hdl.handle.net/10495/43638 http://bibpurl.oclc.org/web/38913 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
J. Hum. Reprod. Sci. |
| dc.relation.citationendpage.spa.fl_str_mv |
101 |
| dc.relation.citationissue.spa.fl_str_mv |
1 |
| dc.relation.citationstartpage.spa.fl_str_mv |
97 |
| dc.relation.citationvolume.spa.fl_str_mv |
14 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Journal of Human Reproductive Sciences |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ https://creativecommons.org/licenses/by-nc-sa/4.0/ http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
5 páginas |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.spa.fl_str_mv |
Medknow Publications |
| dc.publisher.place.spa.fl_str_mv |
Bombay, India |
| institution |
Universidad de Antioquia |
| bitstream.url.fl_str_mv |
https://bibliotecadigital.udea.edu.co/bitstreams/fa2ca551-11d1-43fb-8903-0fc762140ceb/download https://bibliotecadigital.udea.edu.co/bitstreams/8bac97e6-657d-499e-8bba-4d11bdcc3adb/download https://bibliotecadigital.udea.edu.co/bitstreams/1c8146ad-4be5-4872-9d3d-50e11d9f004c/download https://bibliotecadigital.udea.edu.co/bitstreams/162d2741-bd95-4d21-b558-66855fad1e2c/download https://bibliotecadigital.udea.edu.co/bitstreams/e6212e75-9e47-42a9-85ce-fccab8150f8c/download |
| bitstream.checksum.fl_str_mv |
e2060682c9c70d4d30c83c51448f4eed 8a4605be74aa9ea9d79846c1fba20a33 9030c4ee685d1366892aa8e11e7c35d1 69fb69628666c6f3ab90532a363a32f5 d5476b65d915358ccb746ac0a72f74b3 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional de la Universidad de Antioquia |
| repository.mail.fl_str_mv |
aplicacionbibliotecadigitalbiblioteca@udea.edu.co |
| _version_ |
1851052357869109248 |
| spelling |
Cadavid Jaramillo, Angela PatriciaBueno Sánchez, Julio CesarÁlvarez Gómez, Ángela MaríaGómez Gutiérrez, Alejandra MaríaRúa Molina, Diana CarolinaGrupo de Investigación en TrombosisGrupo Reproducción2024-11-20T16:19:39Z2024-11-20T16:19:39Z2021Alvarez AM, Gomez-Gutierrez AM, Bueno-Sánchez JC, Rúa-Molina C, Cadavid AP. Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin G. J Hum Reprod Sci. 2021 Jan-Mar;14(1):97-100. doi: 10.4103/jhrs.JHRS_21_20.0974-1208https://hdl.handle.net/10495/4363810.4103/jhrs.JHRS_21_201998-4766http://bibpurl.oclc.org/web/38913ABSTRACT: This is a case report of women with pregnancy morbidity (PM), some of them associated with antiphospholipid syndrome (APS), in which the glycan patterns of immunoglobulin G (IgG) were investigated based on the theory of alteration of glycosylation in autoimmunity. We used lectin blot to determine changes in terminal glycosylation of polyclonal IgG from women with antiphospholipid (aPL) antibodies and PM plus vascular thrombosis (PM/VT) and seronegative-obstetric APS (SN-OAPS). In addition, we analyzed IgG from women with PM without aPL (PM/aPL-) and healthy women, as controls. Even though the SN-OAPS and PM/VT groups share the PM, only the SN-OAPS group showed a decreased expression of galactose compared to the healthy group. We also found the presence of mannosylated oligosaccharides in IgG from all patients being significantly higher in IgG from women of the PM/aPL- group. The differences in glycans presented here could relate to pathological mechanisms of PM associated with APS.Universidad de Antioquia. Vicerrectoría de investigación. Sistema Integrado de Información Universitaria - SIIUCOL0010421COL00076315 páginasapplication/pdfengMedknow PublicationsBombay, Indiahttp://creativecommons.org/licenses/by-nc-sa/2.5/co/https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Obstetric Antiphospholipid Syndrome: An Approach from Glycans of the Immunoglobulin GReporte de casohttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTCASOhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAnticuerpos AntifosfolípidosAntibodies, AntiphospholipidSíndrome AntifosfolípidoAntiphospholipid SyndromeGlicosilaciónGlycosylationInmunoglobulina GImmunoglobulin GTrombosisThrombosisComplicaciones del EmbarazoPregnancy ComplicationsAutoinmunidadAutoimmunityhttps://id.nlm.nih.gov/mesh/D017152https://id.nlm.nih.gov/mesh/D016736https://id.nlm.nih.gov/mesh/D006031https://id.nlm.nih.gov/mesh/D007074https://id.nlm.nih.gov/mesh/D013927https://id.nlm.nih.gov/mesh/D011248https://id.nlm.nih.gov/mesh/D015551J. Hum. Reprod. Sci.10119714Journal of Human Reproductive Sciences2017‑14586PublicationCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051https://bibliotecadigital.udea.edu.co/bitstreams/fa2ca551-11d1-43fb-8903-0fc762140ceb/downloade2060682c9c70d4d30c83c51448f4eedMD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/8bac97e6-657d-499e-8bba-4d11bdcc3adb/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADORIGINALCadavidAngela_2021_Obstetric_Antiphospholipid_Syndrome.pdfCadavidAngela_2021_Obstetric_Antiphospholipid_Syndrome.pdfapplication/pdf1203594https://bibliotecadigital.udea.edu.co/bitstreams/1c8146ad-4be5-4872-9d3d-50e11d9f004c/download9030c4ee685d1366892aa8e11e7c35d1MD51trueAnonymousREADTEXTCadavidAngela_2021_Obstetric_Antiphospholipid_Syndrome.pdf.txtCadavidAngela_2021_Obstetric_Antiphospholipid_Syndrome.pdf.txtExtracted texttext/plain16121https://bibliotecadigital.udea.edu.co/bitstreams/162d2741-bd95-4d21-b558-66855fad1e2c/download69fb69628666c6f3ab90532a363a32f5MD54falseAnonymousREADTHUMBNAILCadavidAngela_2021_Obstetric_Antiphospholipid_Syndrome.pdf.jpgCadavidAngela_2021_Obstetric_Antiphospholipid_Syndrome.pdf.jpgGenerated Thumbnailimage/jpeg16984https://bibliotecadigital.udea.edu.co/bitstreams/e6212e75-9e47-42a9-85ce-fccab8150f8c/downloadd5476b65d915358ccb746ac0a72f74b3MD55falseAnonymousREAD10495/43638oai:bibliotecadigital.udea.edu.co:10495/436382025-03-26 21:04:43.537http://creativecommons.org/licenses/by-nc-sa/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |