Nasal Provocation Test with Cat and Dog Extracts: Results according to Molecular Components

ABSTRACT: Background: IgE sensitization (atopy) to pets is commonly evaluated using pet dander extracts. However, the diagnosis by components seems to be more adequate to evaluate the clinical relevance (allergy) of sIgE sensitization. Objective: To study the association between IgE sensitization to pet allergen components and clinical symptoms. Methodology. Dander extracts and sIgE levels to pet components (Can f 1, Can f 2, Can f 3, Can f 5, Fel d 1, Fel 2, and Fel 4) were measured in a rhinitis group (n = 101) and a control group (n = 101) and a control group (. Results: Dog (34.6% vs. 23.5%) and cat dander (26.7% vs. 8.8%, p = 0.05) IgE sensitization was frequent among rhinitis and no-rhinitis subjects, and it was similar to dog (29.7% vs. 20.5%) and cat (18.8% vs. 8.8%) components. Polysensitization for dog (3.1, 95% CI: 1.5 to 6.1, p = 0.05) IgE sensitization was frequent among rhinitis and no-rhinitis subjects, and it was similar to dog (29.7% vs. 20.5%) and cat (18.8% vs. 8.8%) components. Polysensitization for dog (3.1, 95% CI: 1.5 to 6.1, p = 0.05) IgE sensitization was frequent among rhinitis and no-rhinitis subjects, and it was similar to dog (29.7% vs. 20.5%) and cat (18.8% vs. 8.8%) components. Polysensitization for dog (3.1, 95% CI: 1.5 to 6.1. Conclusions: Sensitization to pet dander extract identifies atopic patients, but its utility to predict clinical relevance is poor. Allergenic components could help to define the clinical relevance of sensitization to furry animals and could reduce the need for provocation test.

• Autores: Sánchez Caraballo, Andrés; Ricardo Villa, Ricardo; Munera, Marlon Gustavo; Calvo Betancur, Víctor Daniel; Tejada Giraldo, Manuela; Sánchez Caraballo, Jorge Mario
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2020
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/44195
• Acceso en línea: https://hdl.handle.net/10495/44195
• Palabra clave: Hipersensibilidad; Hypersensitivity; Inmunoglobulina E; Immunoglobulin E; Pruebas de Provocación Nasal; Nasal Provocation Tests; Rinitis; Rhinitis; Animales; Animals; Alérgenos - efectos adversos; Allergens - adverse effects; Alérgenos - immunología; Allergens - immunology; Perros; Dogs; Gatos; Cats; Preescolar; Child, Preschool; https://id.nlm.nih.gov/mesh/D006967; https://id.nlm.nih.gov/mesh/D007073; https://id.nlm.nih.gov/mesh/D009299; https://id.nlm.nih.gov/mesh/D012220; https://id.nlm.nih.gov/mesh/D000818; https://id.nlm.nih.gov/mesh/D000485; https://id.nlm.nih.gov/mesh/D004285; https://id.nlm.nih.gov/mesh/D002415; https://id.nlm.nih.gov/mesh/D002675
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/