The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer's disease

ABSTRACT: Background: To determine whether performance on the Latin American Spanish version of the Face-Name Associative Memory Exam (LAS-FNAME) can differentiate between cognitively intact carriers of an autosomal dominant Alzheimer's disease mutation (E280A) in Presenilin-1, who are genetically determined to develop early-onset dementia, from matched non-carriers. We also sought to examine whether LAS-FNAME performance is associated with amyloid-β and regional tau burden in mutation carriers. Methods: A total of 35 cognitively intact mutation carriers (age range 26-41), 19 symptomatic carriers, and 48 matched non-carriers (age range 27-44) completed a neuropsychological assessment including the LAS-FNAME. A subset of participants (31 carriers [12 symptomatic] and 35 non-carriers) traveled from Colombia to Boston to undergo positron emission tomography (PET) using Pittsburgh compound B to measure mean cortical amyloid-β and flortaucipir for regional tau. ANOVA analyses and Spearman correlations were used to examine group differences and relationships among LAS-FNAME performance and amyloid-β and tau accumulation. Results: Compared to non-carriers, cognitively intact mutation carriers had lower scores on the LAS-FNAME Total Scores (p = .040). Across all carriers (including symptomatic carriers), higher levels of amyloid-β (r = - .436, p = .018) and regional tau in the entorhinal (r = - .394, p = .031) and inferior temporal cortex (r = - .563, p = .001) were associated with lower LAS-FNAME Total Scores. Conclusions: Performance on the LAS-FNAME differentiated between cognitively intact mutation carriers from non-carriers and was associated with greater amyloid and tau burden when examining all carriers. Findings suggest that the LAS-FNAME is sensitive to early clinical and pathological changes and can potentially help track disease progression in Spanish-speaking individuals. Keywords: Alzheimer’s disease; Associative memory; Autosomal dominant Alzheimer’s disease; Imaging; Neuropsychology; PET.

• Autores: Baena Pineda, Ana Yulied; Bocanegra García, Orfa Yamile; Lopera Restrepo, Francisco Javier; Vila Castelar, Clara; Muñoz, Nathalia; Papp, Kathryn V.; Amariglio, Rebecca E.; Guzmán Vélez, Edmarie; Sánchez, Justin S.; Reiman, Eric M.; Johnson, Keith A.; Sperling, Reisa A.; Rentz, Dorene M.; Quiroz Gaviria, Yakeel Tatiana
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2020
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/43064
• Acceso en línea: https://hdl.handle.net/10495/43064
• Palabra clave: Alzheimer Disease; Enfermedad de Alzheimer; Cognition; Cognición; Positron-Emission Tomography; Tomografía de Emisión de Positrones; Presenilin-1; Presenilina-1; https://id.nlm.nih.gov/mesh/D053764; https://id.nlm.nih.gov/mesh/D000544; https://id.nlm.nih.gov/mesh/D003071; https://id.nlm.nih.gov/mesh/D049268
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/