European Position Paper on Rhinosinusitis and Nasal Polyps 2020

ABSTRACT: The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integ...

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Autores:
Bedoya Gutiérrez, Juan David
Lund, V. J.
Hopkins, C.
Hellings, P.W.
Kern, R.
Reitsma, S.
Toppila Salmi, S.
Bernal, Sprekelsen M.
Mullol, J.
Alobid, I.
Anselmo Lima, W. T.
Bachert, C.
Baroody, F.
von, Buchwald C.
Cervin, A.
Cohen, N.
Constantinidis, J.
De Gabory, L.
Desrosiers, M.
Diamant, Z.
Douglas, R. G.
Gevaert, P. H.
Hafner, A.
Harvey, R. J.
Joos, G. F.
Kalogjera, L.
Knill, A.
Kocks, J. H.
Landis, B. N.
Limpens, J.
Lebeer, S.
Lourenco, O.
Meco, C.
Matricardi, P. M.
O'Mahony, L.
Philpott, C. M.
Ryan, D.
Schlosser, R.
Senior, B.
Smith, T. L.
Teeling, T.
Tomazic, P. V.
Wang, D. Y.
Wang, D.
Zhang, L.
Agius, A. M.
Ahlstrom, C. Emanuelsson
Alabri, R.
Albu, S.
Alhabash, S.
Aleksic, A.
Aloulah, M.
Al-Qudah, M.
Alsaleh, S.
Baban, M. A.
Baudoin, T.
Balvers, T.
Battaglia, P.
Beule, A.
Bofares, K. M.
Braverman, I.
Brozek Madry, E.
Richard, B.
Callejas, C.
Carrie, S.
Caulley, L.
Chussi, D.
de Corso, E.
Coste, A.
El Hadi, U.
Elfarouk, A.
Eloy, P. H.
Farrokhi, S.
Felisati, G.
Ferrari, M. D.
Fishchuk, R.
Grayson, W.
Goncalves, P. M.
Grdinic, B.
Grgic, V.
Hamizan, A. W.
Heinichen, J. V.
Husain, S.
Ping, T. I.
Ivaska, J.
Jakimovska, F.
Jovancevic, L.
Kakande, E.
Kamel, R.
Fokkens, W. J.
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/45392
Acceso en línea:
https://hdl.handle.net/10495/45392
Palabra clave:
Enfermedad Aguda
Acute Disease
Enfermedad Crónica
Chronic Disease
Pólipos Nasales
Nasal Polyps
Rinitis
Rhinitis
Sinusitis
https://id.nlm.nih.gov/mesh/D000208
https://id.nlm.nih.gov/mesh/D002908
https://id.nlm.nih.gov/mesh/D009298
https://id.nlm.nih.gov/mesh/D012220
https://id.nlm.nih.gov/mesh/D012852
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UDEA2_d449d38a5162376b2a57e64c54ea2297
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/45392
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv European Position Paper on Rhinosinusitis and Nasal Polyps 2020
title European Position Paper on Rhinosinusitis and Nasal Polyps 2020
spellingShingle European Position Paper on Rhinosinusitis and Nasal Polyps 2020
Enfermedad Aguda
Acute Disease
Enfermedad Crónica
Chronic Disease
Pólipos Nasales
Nasal Polyps
Rinitis
Rhinitis
Sinusitis
https://id.nlm.nih.gov/mesh/D000208
https://id.nlm.nih.gov/mesh/D002908
https://id.nlm.nih.gov/mesh/D009298
https://id.nlm.nih.gov/mesh/D012220
https://id.nlm.nih.gov/mesh/D012852
title_short European Position Paper on Rhinosinusitis and Nasal Polyps 2020
title_full European Position Paper on Rhinosinusitis and Nasal Polyps 2020
title_fullStr European Position Paper on Rhinosinusitis and Nasal Polyps 2020
title_full_unstemmed European Position Paper on Rhinosinusitis and Nasal Polyps 2020
title_sort European Position Paper on Rhinosinusitis and Nasal Polyps 2020
dc.creator.fl_str_mv Bedoya Gutiérrez, Juan David
Lund, V. J.
Hopkins, C.
Hellings, P.W.
Kern, R.
Reitsma, S.
Toppila Salmi, S.
Bernal, Sprekelsen M.
Mullol, J.
Alobid, I.
Anselmo Lima, W. T.
Bachert, C.
Baroody, F.
von, Buchwald C.
Cervin, A.
Cohen, N.
Constantinidis, J.
De Gabory, L.
Desrosiers, M.
Diamant, Z.
Douglas, R. G.
Gevaert, P. H.
Hafner, A.
Harvey, R. J.
Joos, G. F.
Kalogjera, L.
Knill, A.
Kocks, J. H.
Landis, B. N.
Limpens, J.
Lebeer, S.
Lourenco, O.
Meco, C.
Matricardi, P. M.
O'Mahony, L.
Philpott, C. M.
Ryan, D.
Schlosser, R.
Senior, B.
Smith, T. L.
Teeling, T.
Tomazic, P. V.
Wang, D. Y.
Wang, D.
Zhang, L.
Agius, A. M.
Ahlstrom, C. Emanuelsson
Alabri, R.
Albu, S.
Alhabash, S.
Aleksic, A.
Aloulah, M.
Al-Qudah, M.
Alsaleh, S.
Baban, M. A.
Baudoin, T.
Balvers, T.
Battaglia, P.
Beule, A.
Bofares, K. M.
Braverman, I.
Brozek Madry, E.
Richard, B.
Callejas, C.
Carrie, S.
Caulley, L.
Chussi, D.
de Corso, E.
Coste, A.
El Hadi, U.
Elfarouk, A.
Eloy, P. H.
Farrokhi, S.
Felisati, G.
Ferrari, M. D.
Fishchuk, R.
Grayson, W.
Goncalves, P. M.
Grdinic, B.
Grgic, V.
Hamizan, A. W.
Heinichen, J. V.
Husain, S.
Ping, T. I.
Ivaska, J.
Jakimovska, F.
Jovancevic, L.
Kakande, E.
Kamel, R.
Fokkens, W. J.
dc.contributor.author.none.fl_str_mv Bedoya Gutiérrez, Juan David
Lund, V. J.
Hopkins, C.
Hellings, P.W.
Kern, R.
Reitsma, S.
Toppila Salmi, S.
Bernal, Sprekelsen M.
Mullol, J.
Alobid, I.
Anselmo Lima, W. T.
Bachert, C.
Baroody, F.
von, Buchwald C.
Cervin, A.
Cohen, N.
Constantinidis, J.
De Gabory, L.
Desrosiers, M.
Diamant, Z.
Douglas, R. G.
Gevaert, P. H.
Hafner, A.
Harvey, R. J.
Joos, G. F.
Kalogjera, L.
Knill, A.
Kocks, J. H.
Landis, B. N.
Limpens, J.
Lebeer, S.
Lourenco, O.
Meco, C.
Matricardi, P. M.
O'Mahony, L.
Philpott, C. M.
Ryan, D.
Schlosser, R.
Senior, B.
Smith, T. L.
Teeling, T.
Tomazic, P. V.
Wang, D. Y.
Wang, D.
Zhang, L.
Agius, A. M.
Ahlstrom, C. Emanuelsson
Alabri, R.
Albu, S.
Alhabash, S.
Aleksic, A.
Aloulah, M.
Al-Qudah, M.
Alsaleh, S.
Baban, M. A.
Baudoin, T.
Balvers, T.
Battaglia, P.
Beule, A.
Bofares, K. M.
Braverman, I.
Brozek Madry, E.
Richard, B.
Callejas, C.
Carrie, S.
Caulley, L.
Chussi, D.
de Corso, E.
Coste, A.
El Hadi, U.
Elfarouk, A.
Eloy, P. H.
Farrokhi, S.
Felisati, G.
Ferrari, M. D.
Fishchuk, R.
Grayson, W.
Goncalves, P. M.
Grdinic, B.
Grgic, V.
Hamizan, A. W.
Heinichen, J. V.
Husain, S.
Ping, T. I.
Ivaska, J.
Jakimovska, F.
Jovancevic, L.
Kakande, E.
Kamel, R.
Fokkens, W. J.
dc.contributor.researchgroup.spa.fl_str_mv Grupo de investigación en Otorrinolaringología GIORL
dc.subject.decs.none.fl_str_mv Enfermedad Aguda
Acute Disease
Enfermedad Crónica
Chronic Disease
Pólipos Nasales
Nasal Polyps
Rinitis
Rhinitis
Sinusitis
topic Enfermedad Aguda
Acute Disease
Enfermedad Crónica
Chronic Disease
Pólipos Nasales
Nasal Polyps
Rinitis
Rhinitis
Sinusitis
https://id.nlm.nih.gov/mesh/D000208
https://id.nlm.nih.gov/mesh/D002908
https://id.nlm.nih.gov/mesh/D009298
https://id.nlm.nih.gov/mesh/D012220
https://id.nlm.nih.gov/mesh/D012852
dc.subject.meshuri.none.fl_str_mv https://id.nlm.nih.gov/mesh/D000208
https://id.nlm.nih.gov/mesh/D002908
https://id.nlm.nih.gov/mesh/D009298
https://id.nlm.nih.gov/mesh/D012220
https://id.nlm.nih.gov/mesh/D012852
description ABSTRACT: The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. EPOS2020 provides an update on the literature published and studies undertaken in the eight years since the EPOS2012 position paper was published and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery. EPOS2020 also involves new stakeholders, including pharmacists and patients, and addresses new target users who have become more involved in the management and treatment of rhinosinusitis since the publication of the last EPOS document, including pharmacists, nurses, specialised care givers and indeed patients themselves, who employ increasing self-management of their condition using over the counter treatments. The document provides suggestions for future research in this area and offers updated guidance for definitions and outcome measurements in research in different settings. EPOS2020 contains chapters on definitions and classification where we have defined a large number of terms and indicated preferred terms. A new classification of CRS into primary and secondary CRS and further division into localized and diffuse disease, based on anatomic distribution is proposed. There are extensive chapters on epidemiology and predisposing factors, inflammatory mechanisms, (differential) diagnosis of facial pain, allergic rhinitis, genetics, cystic fibrosis, aspirin exacerbated respiratory disease, immunodeficiencies, allergic fungal rhinosinusitis and the relationship between upper and lower airways. The chapters on paediatric acute and chronic rhinosinusitis are totally rewritten. All available evidence for the management of acute rhinosinusitis and chronic rhinosinusitis with or without nasal polyps in adults and children is systematically reviewed and integrated care pathways based on the evidence are proposed. Despite considerable increases in the amount of quality publications in recent years, a large number of practical clinical questions remain. It was agreed that the best way to address these was to conduct a Delphi exercise . The results have been integrated into the respective sections. Last but not least, advice for patients and pharmacists and a new list of research needs are included.
publishDate 2020
dc.date.issued.none.fl_str_mv 2020
dc.date.accessioned.none.fl_str_mv 2025-03-08T17:12:14Z
dc.date.available.none.fl_str_mv 2025-03-08T17:12:14Z
dc.type.spa.fl_str_mv Artículo de investigación
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dc.identifier.doi.none.fl_str_mv 10.4193/Rhin20.600
dc.identifier.eissn.none.fl_str_mv 1996-8604
identifier_str_mv 0300-0729
10.4193/Rhin20.600
1996-8604
url https://hdl.handle.net/10495/45392
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Rhinology
dc.relation.citationendpage.spa.fl_str_mv 484
dc.relation.citationissue.spa.fl_str_mv suplemento 29
dc.relation.citationstartpage.spa.fl_str_mv 1
dc.relation.citationvolume.spa.fl_str_mv 58
dc.relation.ispartofjournal.spa.fl_str_mv Rhinology
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dc.format.extent.spa.fl_str_mv 484 páginas
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dc.publisher.spa.fl_str_mv International Rhinologic Society
dc.publisher.place.spa.fl_str_mv Leiden, Países Bajos
institution Universidad de Antioquia
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spelling Bedoya Gutiérrez, Juan DavidLund, V. J.Hopkins, C.Hellings, P.W.Kern, R.Reitsma, S.Toppila Salmi, S.Bernal, Sprekelsen M.Mullol, J.Alobid, I.Anselmo Lima, W. T.Bachert, C.Baroody, F.von, Buchwald C.Cervin, A.Cohen, N.Constantinidis, J.De Gabory, L.Desrosiers, M.Diamant, Z.Douglas, R. G.Gevaert, P. H.Hafner, A.Harvey, R. J.Joos, G. F.Kalogjera, L.Knill, A.Kocks, J. H.Landis, B. N.Limpens, J.Lebeer, S.Lourenco, O.Meco, C.Matricardi, P. M.O'Mahony, L.Philpott, C. M.Ryan, D.Schlosser, R.Senior, B.Smith, T. L.Teeling, T.Tomazic, P. V.Wang, D. Y.Wang, D.Zhang, L.Agius, A. M.Ahlstrom, C. EmanuelssonAlabri, R.Albu, S.Alhabash, S.Aleksic, A.Aloulah, M.Al-Qudah, M.Alsaleh, S.Baban, M. A.Baudoin, T.Balvers, T.Battaglia, P.Beule, A.Bofares, K. M.Braverman, I.Brozek Madry, E.Richard, B.Callejas, C.Carrie, S.Caulley, L.Chussi, D.de Corso, E.Coste, A.El Hadi, U.Elfarouk, A.Eloy, P. H.Farrokhi, S.Felisati, G.Ferrari, M. D.Fishchuk, R.Grayson, W.Goncalves, P. M.Grdinic, B.Grgic, V.Hamizan, A. W.Heinichen, J. V.Husain, S.Ping, T. I.Ivaska, J.Jakimovska, F.Jovancevic, L.Kakande, E.Kamel, R.Fokkens, W. J.Grupo de investigación en Otorrinolaringología GIORL2025-03-08T17:12:14Z2025-03-08T17:12:14Z20200300-0729https://hdl.handle.net/10495/4539210.4193/Rhin20.6001996-8604ABSTRACT: The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. EPOS2020 provides an update on the literature published and studies undertaken in the eight years since the EPOS2012 position paper was published and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery. EPOS2020 also involves new stakeholders, including pharmacists and patients, and addresses new target users who have become more involved in the management and treatment of rhinosinusitis since the publication of the last EPOS document, including pharmacists, nurses, specialised care givers and indeed patients themselves, who employ increasing self-management of their condition using over the counter treatments. The document provides suggestions for future research in this area and offers updated guidance for definitions and outcome measurements in research in different settings. EPOS2020 contains chapters on definitions and classification where we have defined a large number of terms and indicated preferred terms. A new classification of CRS into primary and secondary CRS and further division into localized and diffuse disease, based on anatomic distribution is proposed. There are extensive chapters on epidemiology and predisposing factors, inflammatory mechanisms, (differential) diagnosis of facial pain, allergic rhinitis, genetics, cystic fibrosis, aspirin exacerbated respiratory disease, immunodeficiencies, allergic fungal rhinosinusitis and the relationship between upper and lower airways. The chapters on paediatric acute and chronic rhinosinusitis are totally rewritten. All available evidence for the management of acute rhinosinusitis and chronic rhinosinusitis with or without nasal polyps in adults and children is systematically reviewed and integrated care pathways based on the evidence are proposed. Despite considerable increases in the amount of quality publications in recent years, a large number of practical clinical questions remain. It was agreed that the best way to address these was to conduct a Delphi exercise . The results have been integrated into the respective sections. Last but not least, advice for patients and pharmacists and a new list of research needs are included.COL0211869484 páginasapplication/pdfengInternational Rhinologic SocietyLeiden, Países Bajoshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2European Position Paper on Rhinosinusitis and Nasal Polyps 2020Artículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionEnfermedad AgudaAcute DiseaseEnfermedad CrónicaChronic DiseasePólipos NasalesNasal PolypsRinitisRhinitisSinusitishttps://id.nlm.nih.gov/mesh/D000208https://id.nlm.nih.gov/mesh/D002908https://id.nlm.nih.gov/mesh/D009298https://id.nlm.nih.gov/mesh/D012220https://id.nlm.nih.gov/mesh/D012852Rhinology484suplemento 29158RhinologyPublicationORIGINALBedoyaJuan_2020_European_Rhinosinusitis_Nasal.pdfBedoyaJuan_2020_European_Rhinosinusitis_Nasal.pdfArtículo de investigaciónapplication/pdf27891829https://bibliotecadigital.udea.edu.co/bitstreams/fe530191-631e-4d15-be69-8ce5fb3cc2d5/downloade56ad125cbdf49e625eb77a669068a60MD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstreams/91b3a990-4697-4456-ba8a-cd5211a536a8/downloadb88b088d9957e670ce3b3fbe2eedbc13MD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/fe873e89-8e38-45cd-bde0-31459d0d285e/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTBedoyaJuan_2020_European_Rhinosinusitis_Nasal.pdf.txtBedoyaJuan_2020_European_Rhinosinusitis_Nasal.pdf.txtExtracted texttext/plain100847https://bibliotecadigital.udea.edu.co/bitstreams/bca42f61-4f12-400d-b7e2-817179b7cad8/download91356754eaa40c3ef83493caf35c19c2MD54falseAnonymousREADTHUMBNAILBedoyaJuan_2020_European_Rhinosinusitis_Nasal.pdf.jpgBedoyaJuan_2020_European_Rhinosinusitis_Nasal.pdf.jpgGenerated Thumbnailimage/jpeg15065https://bibliotecadigital.udea.edu.co/bitstreams/3a4b2b12-44a4-4a3d-9f21-4ddf245f8d6d/downloadf9a994197797bfa5577957910af179adMD55falseAnonymousREAD10495/45392oai:bibliotecadigital.udea.edu.co:10495/453922025-03-26 22:46:13.762http://creativecommons.org/licenses/by-nc-nd/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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