An approach to the etiology of metabolic syndrome
ABSTRACT: Increased prevalence of obesity in the world, especially accumulation of abnormal amounts of visceral fat predisposes to insulin resistance, which is the central role of metabolic syndrome (MS). Obesity can deregulate the intracellular signaling of insulin due to the production of inflamma...
- Autores:
-
Muñoz Contreras, Angélica María
Bedoya Berrío, Gabriel de Jesús
Velásquez Rodríguez, Claudia María
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2013
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/21021
- Acceso en línea:
- http://hdl.handle.net/10495/21021
- Palabra clave:
- Metabolic syndrome
Síndrome Metabólico
obesity
Obesidad
insulin resistance
Resistencia a la insulina
Genetics
Genética
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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An approach to the etiology of metabolic syndrome |
| dc.title.translated.spa.fl_str_mv |
Un acercamiento a la etiología del síndrome metabólico |
| title |
An approach to the etiology of metabolic syndrome |
| spellingShingle |
An approach to the etiology of metabolic syndrome Metabolic syndrome Síndrome Metabólico obesity Obesidad insulin resistance Resistencia a la insulina Genetics Genética |
| title_short |
An approach to the etiology of metabolic syndrome |
| title_full |
An approach to the etiology of metabolic syndrome |
| title_fullStr |
An approach to the etiology of metabolic syndrome |
| title_full_unstemmed |
An approach to the etiology of metabolic syndrome |
| title_sort |
An approach to the etiology of metabolic syndrome |
| dc.creator.fl_str_mv |
Muñoz Contreras, Angélica María Bedoya Berrío, Gabriel de Jesús Velásquez Rodríguez, Claudia María |
| dc.contributor.author.none.fl_str_mv |
Muñoz Contreras, Angélica María Bedoya Berrío, Gabriel de Jesús Velásquez Rodríguez, Claudia María |
| dc.contributor.researchgroup.spa.fl_str_mv |
Alimentación y Nutrición Humana Genética Molecular (GENMOL) |
| dc.subject.decs.none.fl_str_mv |
Metabolic syndrome Síndrome Metabólico obesity Obesidad insulin resistance Resistencia a la insulina Genetics Genética |
| topic |
Metabolic syndrome Síndrome Metabólico obesity Obesidad insulin resistance Resistencia a la insulina Genetics Genética |
| description |
ABSTRACT: Increased prevalence of obesity in the world, especially accumulation of abnormal amounts of visceral fat predisposes to insulin resistance, which is the central role of metabolic syndrome (MS). Obesity can deregulate the intracellular signaling of insulin due to the production of inflammatory substances, chemoattractant proteins, adipokines and molecules that trigger hormonal mediator potentials for destabilization of signal transduction, leading to metabolic disorders such as hyperglycemia, hypertension, and dyslipidemia. The complexity of the MS and of the genetic mechanisms involved in its etiology derives from the combination of variants on genes involved and environmental factors that predispose it. The purpose of this paper is to review the effects of obesity in molecular and biochemical responses that trigger insulin resistance and its relation to some candidate genes and the ancestral component of the population. |
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2013 |
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2013 |
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2021-07-21T20:29:30Z |
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2021-07-21T20:29:30Z |
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Muñoz, AM, Bedoya, G. y Velásquez, C. (2013). Una aproximación a la etiología del síndrome metabólico. Colombia Médica , 44 (1), 57-63. https://doi.org/10.25100/cm.v44i1.813 |
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0120-8322 |
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http://hdl.handle.net/10495/21021 |
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10.25100/cm.v44i1.813 |
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1657-9534 |
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Muñoz, AM, Bedoya, G. y Velásquez, C. (2013). Una aproximación a la etiología del síndrome metabólico. Colombia Médica , 44 (1), 57-63. https://doi.org/10.25100/cm.v44i1.813 0120-8322 10.25100/cm.v44i1.813 1657-9534 |
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http://hdl.handle.net/10495/21021 |
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eng |
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eng |
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Colomb. Med. |
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63 |
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1 |
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57 |
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44 |
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Colombia Médica |
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Universidad del Valle |
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Cali, Colombia |
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Muñoz Contreras, Angélica MaríaBedoya Berrío, Gabriel de JesúsVelásquez Rodríguez, Claudia MaríaAlimentación y Nutrición HumanaGenética Molecular (GENMOL)2021-07-21T20:29:30Z2021-07-21T20:29:30Z2013Muñoz, AM, Bedoya, G. y Velásquez, C. (2013). Una aproximación a la etiología del síndrome metabólico. Colombia Médica , 44 (1), 57-63. https://doi.org/10.25100/cm.v44i1.8130120-8322http://hdl.handle.net/10495/2102110.25100/cm.v44i1.8131657-9534ABSTRACT: Increased prevalence of obesity in the world, especially accumulation of abnormal amounts of visceral fat predisposes to insulin resistance, which is the central role of metabolic syndrome (MS). Obesity can deregulate the intracellular signaling of insulin due to the production of inflammatory substances, chemoattractant proteins, adipokines and molecules that trigger hormonal mediator potentials for destabilization of signal transduction, leading to metabolic disorders such as hyperglycemia, hypertension, and dyslipidemia. The complexity of the MS and of the genetic mechanisms involved in its etiology derives from the combination of variants on genes involved and environmental factors that predispose it. The purpose of this paper is to review the effects of obesity in molecular and biochemical responses that trigger insulin resistance and its relation to some candidate genes and the ancestral component of the population.RESUMEN: El aumento en la prevalencia de la obesidad en el mundo, especialmente el acumulo de grasa visceral, predispone a resistencia a la insulina, eje central del Síndrome metabólico (SM). La obesidad puede desregular la señalización intracelular de la insulina debido a la producción de sustancias inflamatorias, proteínas quimioatrayentes, adipoquinas y mediadores hormonales que activan moléculas potenciales para la desestabilización de la transducción de la señal, lo que genera alteraciones metabólicas como hiperglucemia, hipertensión y dislipidemia. La complejidad del SM y de los mecanismos genéticos involucrados en su etiología, se deriva de la combinación entre variantes génicas implicadas y factores del medioambiente que la predisponen. El propósito del presente artículo es revisar los efectos de la obesidad en las respuestas moleculares y bioquímicas que desencadenan resistencia a la insulina y su relación con algunos genes candidatos y el componente ancestral de la población.COL0000407COL00067237application/pdfengUniversidad del ValleCali, Colombiahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2An approach to the etiology of metabolic syndromeUn acercamiento a la etiología del síndrome metabólicoArtículo de revisiónhttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionMetabolic syndromeSíndrome MetabólicoobesityObesidadinsulin resistanceResistencia a la insulinaGeneticsGenéticaColomb. Med.6315744Colombia MédicaPublicationCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstreams/72a29bc8-46c4-482e-b158-eace0455c9e4/downloadb88b088d9957e670ce3b3fbe2eedbc13MD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/e3d5f7db-0e44-4b9c-9400-a1e8f24d9eca/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADORIGINALMuñozAngelica_2013_ApproachMetabolicSyndrome.pdfMuñozAngelica_2013_ApproachMetabolicSyndrome.pdfArtículo de revisiónapplication/pdf414448https://bibliotecadigital.udea.edu.co/bitstreams/4b81a11a-b28a-4d5f-9288-9c2d85396875/downloada179c860cd176fd33c984663cd842830MD51trueAnonymousREADTEXTMuñozAngelica_2013_ApproachMetabolicSyndrome.pdf.txtMuñozAngelica_2013_ApproachMetabolicSyndrome.pdf.txtExtracted texttext/plain40299https://bibliotecadigital.udea.edu.co/bitstreams/5812bb12-2e6f-4031-89dd-8d160e3e4752/downloadc1a19d7e78b28ad2149dddf5aa957cf3MD54falseAnonymousREADTHUMBNAILMuñozAngelica_2013_ApproachMetabolicSyndrome.pdf.jpgMuñozAngelica_2013_ApproachMetabolicSyndrome.pdf.jpgGenerated Thumbnailimage/jpeg14495https://bibliotecadigital.udea.edu.co/bitstreams/b6dbfea6-6f9b-4e3f-aed1-68a9fcdaf1e9/download826366d3bc22bcd8285c92b60631d997MD55falseAnonymousREAD10495/21021oai:bibliotecadigital.udea.edu.co:10495/210212025-03-27 00:38:45.606http://creativecommons.org/licenses/by-nc-nd/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |