Interaction between endothelial cell-derived extracellular vesicles and monocytes: A potential link between vascular thrombosis and pregnancy-related morbidity in antiphospholipid syndrome

ABSTRACT: Antiphospholipid syndrome (APS) is an autoimmune disease driven by a wide group of autoantibodies primarily directed against phospholipid-binding proteins (antiphospholipid antibodies). APS is defined by two main kinds of clinical manifestations: vascular thrombosis and pregnancy-related morbidity. In recent years, in vitro and in vivo assays, as well as the study of large groups of patients with APS, have led some authors to suggest that obstetric and vascular manifestations of the disease are probably the result of different pathogenic mechanisms. According to this hypothesis, the disease could be differentiated into two parallel entities: Vascular APS and obstetric APS. Thus, vascular APS is understood as an acquired thrombophilia in which a generalised phenomenon of endothelial activation and dysfunction (coupled with a triggering factor) causes thrombosis at any location. In contrast, obstetric APS seems to be due to an inflammatory phenomenon accompanied by trophoblast cell dysfunction. The recent approach to APS raises new issues; for instance, the mechanisms by which a single set of autoantibodies can lead to two different clinical entities are unclear. This review will address the monocyte, a cell with well-known roles in haemostasis and pregnancy, as a potential participant in vascular thrombosis and pregnancy-related morbidity in APS. We will discuss how in a steady state the monocyte-endothelial interaction occurs via extracellular vesicles (EVs), and how antiphospholipid antibodies, by inducing endothelial activation and dysfunction, may disturb this interaction to promote the release of monocyte-targeted procoagulant and inflammatory messages.

• Autores: Cadavid Jaramillo, Ángela Patricia; Álvarez Jaramillo, Daniel; Morales Prieto, Diana María
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2023
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/43621
• Acceso en línea: https://hdl.handle.net/10495/43621
• Palabra clave: Anticuerpos Antifosfolípidos; Antibodies, Antiphospholipid; Síndrome Antifosfolípido; Antiphospholipid Syndrome; Células Endoteliales; Endothelial Cells; Vesículas Extracelulares; Extracellular Vesicles; Monocitos; Monocytes; Embarazo; Pregnancy; Trombosis; Thrombosis; https://id.nlm.nih.gov/mesh/D017152; https://id.nlm.nih.gov/mesh/D016736; https://id.nlm.nih.gov/mesh/D042783; https://id.nlm.nih.gov/mesh/D000067128; https://id.nlm.nih.gov/mesh/D009000; https://id.nlm.nih.gov/mesh/D011247; https://id.nlm.nih.gov/mesh/D013927
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/