Genetic Variation Underpinning ADHD Risk in a Caribbean Community

ABSTRACT: Attention Deficit Hyperactivity Disorder (ADHD) is a highly heritable and prevalent neurodevelopmental disorder that frequently persists into adulthood. Strong evidence from genetic studies indicates that single nucleotide polymorphisms (SNPs) harboured in the ADGRL3 (LPHN3), SNAP25, FGF1, DRD4, and SLC6A2 genes are associated with ADHD. We genotyped 26 SNPs harboured in genes previously reported to be associated with ADHD and evaluated their potential association in 386 individuals belonging to 113 nuclear families from a Caribbean community in Barranquilla, Colombia, using family-based association tests. SNPs rs362990-SNAP25 (T allele; p = 2.46 × 10−4 ), rs2282794-FGF1 (A allele; p = 1.33 × 10−2 ), rs2122642-ADGRL3 (C allele, p = 3.5 × 10−2 ), and ADGRL3 haplotype CCC (markers rs1565902-rs10001410-rs2122642, OR = 1.74, Ppermuted = 0.021) were significantly associated with ADHD. Our results confirm the susceptibility to ADHD conferred by SNAP25, FGF1, and ADGRL3 variants in a community with a significant African American component, and provide evidence supporting the existence of specific patterns of genetic stratification underpinning the susceptibility to ADHD. Knowledge of population genetics is crucial to define risk and predict susceptibility to disease.

• Autores: Arcos Burgos, Oscar Mauricio; Pineda Salazar, David Antonio; Cervantes Henríquez, Martha Lucía; Martínez Banfi, Martha L.; Mejía Segura, Elsy; Sánchez Rojas, Manuel; Anaya Romero, Marco E.; Acosta Hoyos, Antonio; García Llinás, Guisselle A.; Mastronardi, Claudio A.; Acosta López, Johan; Castellanos, F. Xavier; Puentes Rozo, Pedro; Vélez Valbuena, Jorge Iván
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2019
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/42095
• Acceso en línea: https://hdl.handle.net/10495/42095
• Palabra clave: Trastorno por Déficit de Atención con Hiperactividad; Attention Deficit Disorder with Hyperactivity; Factor 1 de Crecimiento de Fibroblastos; Negro o Afroamericano; Black or African American; Predisposición Genética a la Enfermedad; Genetic Predisposition to Disease; Polimorfismo de Nucleótido Simple; Polymorphism, Single Nucleotide; Receptores Acoplados a Proteínas G; Receptors, G-Protein-Coupled; Receptores de Péptidos; Receptors, Peptide; Proteína 25 Asociada a Sinaptosomas; Synaptosomal-Associated Protein 25; Colombia; Haplotipos; Haplotypes; Fibroblast Growth Factor 1; https://id.nlm.nih.gov/mesh/D001289; https://id.nlm.nih.gov/mesh/D016220; https://id.nlm.nih.gov/mesh/D001741; https://id.nlm.nih.gov/mesh/D020022; https://id.nlm.nih.gov/mesh/D020641; https://id.nlm.nih.gov/mesh/D043562; https://id.nlm.nih.gov/mesh/D018000; https://id.nlm.nih.gov/mesh/D050825; https://id.nlm.nih.gov/mesh/D003105; https://id.nlm.nih.gov/mesh/D006239
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/