Increased expression of secretory leukocyte protease inhibitor in oral mucosa of colombian HIV type 1-exposed seronegative individuals

ABSTRACT:The exposure to human immunodeficiency virus type 1 (HIV-1) does not always result in infection. Indeed, there are individuals who have been repeatedly exposed to HIV-1 but do not exhibit clinical or serological evidence of infection; they are known as HIV-exposed seronegative individuals (HESN). To determine if secretory leukocyte protease inhibitor (SLPI), a soluble factor secreted by epithelial cells lining mucosal surfaces that showed anti-HIV activity in vitro, was associated with natural resistance to HIV infection, we measured by real time RT-PCR the expression of SLPI in oral mucosa of a cohort of Colombian HESN, in chronically HIV-1-infected individuals and in healthy controls. The HESN expressed significantly higher levels of SLPI mRNA than healthy controls (p=0.033) and chronically infected subjects (p=0.011). These findings suggest an association between SLPI expression and the natural resistance to HIV-1 infection exhibited by our HESN cohort.

• Autores: Taborda Vanegas, Natalia Andrea; Zapata Builes, Wildeman; Montoya Guarín, Carlos Julio; Rugeles López, María Teresa
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2012
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/37248
• Acceso en línea: https://hdl.handle.net/10495/37248
• Palabra clave: Adolescente; Adolescent; Colombia; Relación Dosis-Respuesta Inmunológica; Dose-Response Relationship, Immunologic; Epitelio; Epithelium; Seronegatividad para VIH; HIV Seronegativity; VIH-1; HIV-1; Inmunidad Innata; Immunity, Innate; Inmunidad Mucosa; Immunity, Mucosal; Inhibidor Secretorio de Peptidasas Leucocitarias; Secretory Leukocyte Peptidase Inhibitor
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/