Preventive Effect of Quercetin in a Triple Transgenic Alzheimer Disease Mice Model

ABSTRACT: Alzheimer’s disease (AD) is the most common type of dementia and is the leading cause of disability in elderly people worldwide. Current pharmacological therapies do not cure the disease, and for this reason, some pharmacotherapy studies have investigated preventive treatments focused on modifiable nutritional factors such as diet. Quercetin (Qc) is a flavonoid found in fruits and vegetables that has several biological properties. In this study, we evaluated the effect of chronic oral quercetin administration (100 mg/kg) on neurodegeneration markers and cognitive and emotional deficits in a triple transgenic Alzheimer’s disease (3xTg-AD) mouse model using histological and behavioral analyses. Our results suggest that long-term (12 months) oral preventive treatment with quercetin has significant effects on β-amyloidosis reduction and tends to decrease tauopathy in the hippocampus and amygdala. These decreases positively affected the cognitive functional recovery (without modifying the emotional skills) of 3xTg-AD mice. These findings suggest that preventive and chronic administration of Qc might help to delay the development of histopathological hallmarks and cognitive function deficits in AD.

• Autores: Sabogal Guáqueta, Angélica María; Carrillo Hormaza, Luis Carlos; Cardona Gómez, Gloria Patricia; Pérez Corredor, Paula Andrea
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2019
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/38981
• Acceso en línea: https://hdl.handle.net/10495/38981
• Palabra clave: Enfermedad de Alzheimer; Alzheimer Disease; Amyloid beta-Peptides - genética; Amyloid beta-Peptides - genetics; Precursor de Proteína beta-Amiloide - genética; Amyloid beta-Protein Precursor - genetics; Encéfalo - efectos de los fármacos; Brain - drug effects; Encéfalo - patología; Brain - pathology; Trastornos del Conocimiento; Cognition Disorders; Modelos Animales de Enfermedad; Disease Models, Animal; Hipocampo - efectos de los fármacos; Hippocampus - drug effects; Hipocampo - patología; Hippocampus - pathology; Aprendizaje por Laberinto - efectos de los fármacos; Maze Learning - drug effects; Ratones; Mice; Ratones Transgénicos; Mice, Transgenic; Quercetina - farmacología; Quercetin - pharmacology; Proteínas tau - genética; tau Proteins - genetics; https://id.nlm.nih.gov/mesh/D000544; https://id.nlm.nih.gov/mesh/D016229; https://id.nlm.nih.gov/mesh/D016564; https://id.nlm.nih.gov/mesh/D001921; https://id.nlm.nih.gov/mesh/D003072; https://id.nlm.nih.gov/mesh/D004195; https://id.nlm.nih.gov/mesh/D006624; https://id.nlm.nih.gov/mesh/D018782; https://id.nlm.nih.gov/mesh/D051379; https://id.nlm.nih.gov/mesh/D008822; https://id.nlm.nih.gov/mesh/D011794; https://id.nlm.nih.gov/mesh/D016875
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/