Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia)
ABSTRACT: To date, there are only three reports from Colombia about the malaria diagnostic test Now ICT Malaria Pf / Pv ® (NowICT). The results from these studies showed major differences in sensitivity and specificity. Objective: To evaluate the diagnostic performance of NowICT compared to thick sm...
- Autores:
-
Carmona Fonseca, Jaime
Franco Gallego, William Alexander
Arango Flórez, Eliana María
Agudelo García, Olga María
Maestre Buitrago, Amanda Elena
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2010
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/12652
- Acceso en línea:
- http://hdl.handle.net/10495/12652
- Palabra clave:
- Colombia
Diagnóstico
Inmunoquímica
Malaria
Microscopía
Plasmodium falciparum
Plasmodium vivax
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/2.5/co/
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Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia) |
| dc.title.translated.spa.fl_str_mv |
Now ICT malaria Pf/Pv ® versus microscopy (thick-smear, thin smear) for diagnosis of malaria in Urabá (Colombia) |
| title |
Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia) |
| spellingShingle |
Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia) Colombia Diagnóstico Inmunoquímica Malaria Microscopía Plasmodium falciparum Plasmodium vivax |
| title_short |
Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia) |
| title_full |
Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia) |
| title_fullStr |
Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia) |
| title_full_unstemmed |
Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia) |
| title_sort |
Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia) |
| dc.creator.fl_str_mv |
Carmona Fonseca, Jaime Franco Gallego, William Alexander Arango Flórez, Eliana María Agudelo García, Olga María Maestre Buitrago, Amanda Elena |
| dc.contributor.author.none.fl_str_mv |
Carmona Fonseca, Jaime Franco Gallego, William Alexander Arango Flórez, Eliana María Agudelo García, Olga María Maestre Buitrago, Amanda Elena |
| dc.contributor.researchgroup.spa.fl_str_mv |
Salud y Comunidad |
| dc.subject.none.fl_str_mv |
Colombia Diagnóstico Inmunoquímica Malaria Microscopía Plasmodium falciparum Plasmodium vivax |
| topic |
Colombia Diagnóstico Inmunoquímica Malaria Microscopía Plasmodium falciparum Plasmodium vivax |
| description |
ABSTRACT: To date, there are only three reports from Colombia about the malaria diagnostic test Now ICT Malaria Pf / Pv ® (NowICT). The results from these studies showed major differences in sensitivity and specificity. Objective: To evaluate the diagnostic performance of NowICT compared to thick smear for the diagnosis of Plasmodium infection in matched blood samples from mothers (maternal peripheral blood), umbilical cord and placenta. Methods: We used a closed (blinded/masked) and parallel design for the evaluation of a diagnostic test. The sample size was calculated with statistical and epidemiological parameters; this consisted of 131 thick smears from maternal peripheral blood. Blood samples from placenta and umbilical cord were also studied (386 samples tested in total). Results: The sensitivity of Now ICT for detection of P. vivax was below 70% in any of the samples (maternal blood, placental blood or cord blood). The specificity was greater than 99%. Values for P. falciparum infection were not calculated since too few cases were detected. Conclusions: Now ICT Malaria Pf / Pv ® is not a useful diagnostic tool in Colombia since the sensitivity for the most frequent species in the country, P. vivax, is poor. This interpretation is consistent with the WHO’s general conclusions about the state of development of rapid diagnostic tests for malaria. |
| publishDate |
2010 |
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2010 |
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2019-12-19T21:02:19Z |
| dc.date.available.none.fl_str_mv |
2019-12-19T21:02:19Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Carmona-Fonseca J, Franco Gallego A, Arango Flórez E, Agudelo García OM, Maestre Buitrago A. Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia). Iatreia. 2010 Jun;23(2): 137-145. |
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0121-0793 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/12652 |
| dc.identifier.eissn.none.fl_str_mv |
2011-7965 |
| identifier_str_mv |
Carmona-Fonseca J, Franco Gallego A, Arango Flórez E, Agudelo García OM, Maestre Buitrago A. Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia). Iatreia. 2010 Jun;23(2): 137-145. 0121-0793 2011-7965 |
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http://hdl.handle.net/10495/12652 |
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spa |
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spa |
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Iatreia |
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145 |
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2 |
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23 |
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Iatreia |
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https://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
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https://creativecommons.org/licenses/by-nc-sa/4.0/ |
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Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) |
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info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by-nc-sa/2.5/co/ https://creativecommons.org/licenses/by-nc-sa/4.0/ Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO) http://purl.org/coar/access_right/c_abf2 |
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Universidad de Antioquia, Facultad de Medicina |
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Medellín, Colombia |
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Universidad de Antioquia |
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Carmona Fonseca, JaimeFranco Gallego, William AlexanderArango Flórez, Eliana MaríaAgudelo García, Olga MaríaMaestre Buitrago, Amanda ElenaSalud y Comunidad2019-12-19T21:02:19Z2019-12-19T21:02:19Z2010Carmona-Fonseca J, Franco Gallego A, Arango Flórez E, Agudelo García OM, Maestre Buitrago A. Now ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia). Iatreia. 2010 Jun;23(2): 137-145.0121-0793http://hdl.handle.net/10495/126522011-7965ABSTRACT: To date, there are only three reports from Colombia about the malaria diagnostic test Now ICT Malaria Pf / Pv ® (NowICT). The results from these studies showed major differences in sensitivity and specificity. Objective: To evaluate the diagnostic performance of NowICT compared to thick smear for the diagnosis of Plasmodium infection in matched blood samples from mothers (maternal peripheral blood), umbilical cord and placenta. Methods: We used a closed (blinded/masked) and parallel design for the evaluation of a diagnostic test. The sample size was calculated with statistical and epidemiological parameters; this consisted of 131 thick smears from maternal peripheral blood. Blood samples from placenta and umbilical cord were also studied (386 samples tested in total). Results: The sensitivity of Now ICT for detection of P. vivax was below 70% in any of the samples (maternal blood, placental blood or cord blood). The specificity was greater than 99%. Values for P. falciparum infection were not calculated since too few cases were detected. Conclusions: Now ICT Malaria Pf / Pv ® is not a useful diagnostic tool in Colombia since the sensitivity for the most frequent species in the country, P. vivax, is poor. This interpretation is consistent with the WHO’s general conclusions about the state of development of rapid diagnostic tests for malaria.RESUMEN: Solo conocemos tres informes para Colombia de la prueba diagnóstica de malaria Now ICT Malaria Pf/Pv ® (NowICT); esos estudios tuvieron resultados de sensibilidad y especificidad muy diferentes. Objetivo: evaluar la capacidad diagnóstica de NowICT frente a la gota gruesa para el diagnóstico de infección plasmodial en sangres periférica materna, del cordón umbilical y placentaria. Metodología: diseño paralelo y enmascarado para evaluación de una prueba diagnóstica. El tamaño de la muestra se calculó con parámetros epidemiológicos y estadísticos y fue de 131 muestras de sangre periférica materna; también se examinaron sendas muestras de sangre placentaria y de cordón umbilical. Resultados: se evaluaron en total 386 muestras. La sensibilidad de NowICT para P. vivax no alcanzó 70% en ninguna de las fuentes (madre, placenta, cordón). La especificidad mínima fue de 99%. Los valores para P. falciparum no se calcularon porque los casos fueron pocos. Conclusión: Now ICT malaria Pf/Pv® no es una herramienta diagnóstica útil en Colombia porque su sensibilidad para P. vivax es muy deficiente y en el país esta especie es la que predomina en la generación de malaria en humanos. Esta interpretación concuerda con las conclusiones generales de la OMS sobre el estado de desarrollo de las pruebas diagnósticas rápidas para malaria.9application/pdfspaUniversidad de Antioquia, Facultad de MedicinaMedellín, Colombiahttps://creativecommons.org/licenses/by-nc-sa/2.5/co/https://creativecommons.org/licenses/by-nc-sa/4.0/Atribución-NoComercial-CompartirIgual 2.5 Colombia (CC BY-NC-SA 2.5 CO)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2ColombiaDiagnósticoInmunoquímicaMalariaMicroscopíaPlasmodium falciparumPlasmodium vivaxNow ICT malaria Pf/Pv® frente a microscopía (gota gruesa-extendido) para diagnóstico de malaria en Urabá (Colombia)Now ICT malaria Pf/Pv ® versus microscopy (thick-smear, thin smear) for diagnosis of malaria in Urabá (Colombia)Artículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionIatreia145223IatreiaPublicationORIGINALCarmonaJaime_2010_NowICTMalaria.pdfCarmonaJaime_2010_NowICTMalaria.pdfArtículo de investigaciónapplication/pdf116446https://bibliotecadigital.udea.edu.co/bitstreams/4d453eef-7791-4ca2-a218-28ac6f9290ec/downloada7c5713cc2e2e4a7228d888922f2dfe2MD51trueAnonymousREADCC-LICENSElicense_urllicense_urltext/plain; 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