Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic
ABSTRACT: Verapamil hydrochloride is a drug used to treat arrhythmias. In this study, a D-optimal mixture design with 16 runs was used to select the best combination of three polymers into a matrix that rendered an 8 h in vitro release profile of verapamil. hydrochloride (HCl) which fulfill a once-a...
- Autores:
-
Rojas Camargo, John Jairo
Aristizábal, Julián
Sánchez, Joan
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2013
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/25207
- Acceso en línea:
- http://hdl.handle.net/10495/25207
- Palabra clave:
- Verapamilo
Verapamil
Dinámicas no Lineales
Nonlinear Dynamics
Diseño experimental
Experimental design
Controlled-release preparations
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
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| dc.title.spa.fl_str_mv |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| title |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| spellingShingle |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic Verapamilo Verapamil Dinámicas no Lineales Nonlinear Dynamics Diseño experimental Experimental design Controlled-release preparations |
| title_short |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| title_full |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| title_fullStr |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| title_full_unstemmed |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| title_sort |
Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kinetic |
| dc.creator.fl_str_mv |
Rojas Camargo, John Jairo Aristizábal, Julián Sánchez, Joan |
| dc.contributor.author.none.fl_str_mv |
Rojas Camargo, John Jairo Aristizábal, Julián Sánchez, Joan |
| dc.contributor.researchgroup.spa.fl_str_mv |
Diseño y Formulación de Medicamentos Cosméticos y Afines |
| dc.subject.decs.none.fl_str_mv |
Verapamilo Verapamil Dinámicas no Lineales Nonlinear Dynamics |
| topic |
Verapamilo Verapamil Dinámicas no Lineales Nonlinear Dynamics Diseño experimental Experimental design Controlled-release preparations |
| dc.subject.lemb.none.fl_str_mv |
Diseño experimental Experimental design |
| dc.subject.proposal.spa.fl_str_mv |
Controlled-release preparations |
| description |
ABSTRACT: Verapamil hydrochloride is a drug used to treat arrhythmias. In this study, a D-optimal mixture design with 16 runs was used to select the best combination of three polymers into a matrix that rendered an 8 h in vitro release profile of verapamil. hydrochloride (HCl) which fulfill a once-a-day modified release in compliance with the United States Pharmacopeia (USP) specifications. The Korsmeyer-Peppas model was used to fit the dissolution data since it presented the best fitting characteristics. A cubic model predicted the best formulation of verapamil.HCl containing carnauba wax, hydroxypropyl methyl cellulose and Avicel_PH101 at the 40, 20 and 40% levels, respectively. Validation runs confirmed the accuracy of the cubic models which include these three components. |
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2013 |
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2013 |
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2022-01-08T16:28:25Z |
| dc.date.available.none.fl_str_mv |
2022-01-08T16:28:25Z |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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http://hdl.handle.net/10495/25207 |
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10.5897/AJPP2013.3466 |
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1996-0816 |
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http://hdl.handle.net/10495/25207 |
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10.5897/AJPP2013.3466 1996-0816 |
| dc.language.iso.spa.fl_str_mv |
eng |
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eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Afr. J. Pharm. Pharmacol. |
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800 |
| dc.relation.citationissue.spa.fl_str_mv |
15 |
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793 |
| dc.relation.citationvolume.spa.fl_str_mv |
7 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
African Journal of Pharmacy and Pharmacology |
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http://creativecommons.org/licenses/by/2.5/co/ |
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https://creativecommons.org/licenses/by/4.0/ |
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Academic Journals |
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Lagos, Nigeria |
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Universidad de Antioquia |
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Rojas Camargo, John JairoAristizábal, JuliánSánchez, JoanDiseño y Formulación de Medicamentos Cosméticos y Afines2022-01-08T16:28:25Z2022-01-08T16:28:25Z2013http://hdl.handle.net/10495/2520710.5897/AJPP2013.34661996-0816ABSTRACT: Verapamil hydrochloride is a drug used to treat arrhythmias. In this study, a D-optimal mixture design with 16 runs was used to select the best combination of three polymers into a matrix that rendered an 8 h in vitro release profile of verapamil. hydrochloride (HCl) which fulfill a once-a-day modified release in compliance with the United States Pharmacopeia (USP) specifications. The Korsmeyer-Peppas model was used to fit the dissolution data since it presented the best fitting characteristics. A cubic model predicted the best formulation of verapamil.HCl containing carnauba wax, hydroxypropyl methyl cellulose and Avicel_PH101 at the 40, 20 and 40% levels, respectively. Validation runs confirmed the accuracy of the cubic models which include these three components.COL00036237application/pdfengAcademic JournalsLagos, Nigeriahttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Assessment of a modified release verapamil.HCl matrix compacts : Effect of formulation composition on the in-vitro release kineticArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionVerapamiloVerapamilDinámicas no LinealesNonlinear DynamicsDiseño experimentalExperimental designControlled-release preparationsAfr. J. Pharm. 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