Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report
ABSTRACT: We present an 18-year-old female with sickle cell disease, who presented with an extensive lower leg ulcer over a 12-year course of the disease. Definitive reconstruction was made using a free latissimus dorsi flap and split-skin grafts. One week before the surgery, the plasmapheresis prot...
- Autores:
-
Posso Zapata, Carolina María
Cuéllar Ambrosi, Francisco
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/44926
- Acceso en línea:
- https://hdl.handle.net/10495/44926
- Palabra clave:
- Colgajos Tisulares Libres
Free Tissue Flaps
Anemia de Células Falciformes
Anemia, Sickle Cell
Úlcera
Ulcer
https://id.nlm.nih.gov/mesh/D058752
https://id.nlm.nih.gov/mesh/D000755
https://id.nlm.nih.gov/mesh/D014456
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc/4.0/
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Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report |
| title |
Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report |
| spellingShingle |
Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report Colgajos Tisulares Libres Free Tissue Flaps Anemia de Células Falciformes Anemia, Sickle Cell Úlcera Ulcer https://id.nlm.nih.gov/mesh/D058752 https://id.nlm.nih.gov/mesh/D000755 https://id.nlm.nih.gov/mesh/D014456 |
| title_short |
Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report |
| title_full |
Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report |
| title_fullStr |
Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report |
| title_full_unstemmed |
Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report |
| title_sort |
Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report |
| dc.creator.fl_str_mv |
Posso Zapata, Carolina María Cuéllar Ambrosi, Francisco |
| dc.contributor.author.none.fl_str_mv |
Posso Zapata, Carolina María Cuéllar Ambrosi, Francisco |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Investigación en Cirugía Plástica Universidad de Antioquia |
| dc.subject.decs.none.fl_str_mv |
Colgajos Tisulares Libres Free Tissue Flaps Anemia de Células Falciformes Anemia, Sickle Cell Úlcera Ulcer |
| topic |
Colgajos Tisulares Libres Free Tissue Flaps Anemia de Células Falciformes Anemia, Sickle Cell Úlcera Ulcer https://id.nlm.nih.gov/mesh/D058752 https://id.nlm.nih.gov/mesh/D000755 https://id.nlm.nih.gov/mesh/D014456 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D058752 https://id.nlm.nih.gov/mesh/D000755 https://id.nlm.nih.gov/mesh/D014456 |
| description |
ABSTRACT: We present an 18-year-old female with sickle cell disease, who presented with an extensive lower leg ulcer over a 12-year course of the disease. Definitive reconstruction was made using a free latissimus dorsi flap and split-skin grafts. One week before the surgery, the plasmapheresis protocol and blood transfusion were administered, in order to achieve a hemoglobin S level of ≤ 30%. Intraoperatively, the flap pedicle was rinsed with plasminogen activator inhibitor-1 until the thrombolytic agent was obtained from the comitant vein; after the arterial flow had been released, an intravenous bolus dose of heparin (2000 U) was administrated. No vascular complications occurred. Postoperatively, the patient received a 10-d course of hemodilution and a 14-d course of full-dose anticoagulation. After 8 mo postoperatively, the patient was able to walk and run, and showed complete wound healing. This case indicates that sickle cell disease is not a contraindication to free tissue transfer; however, the complications, their rate and overall outcomes for these cases are not yet clear. Herein, we provide an algorithm based on our clinical experience in this type of case and treatment, including several recommendations that may help to reduce thrombosis risk and systemic complications. |
| publishDate |
2016 |
| dc.date.issued.none.fl_str_mv |
2016 |
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2025-02-16T20:07:18Z |
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2025-02-16T20:07:18Z |
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Reporte de caso |
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http://purl.org/coar/resource_type/c_6501 |
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https://purl.org/redcol/resource_type/ARTCASO |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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Posso C, Cuéllar-Ambrosi F. Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report. World J Hematol 2016; 5(4): 94-98 DOI: 10.5315/wjh.v5.i4.94 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/44926 |
| dc.identifier.doi.none.fl_str_mv |
10.5315/wjh.v5.i4.94 |
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2218-6204 |
| identifier_str_mv |
Posso C, Cuéllar-Ambrosi F. Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report. World J Hematol 2016; 5(4): 94-98 DOI: 10.5315/wjh.v5.i4.94 10.5315/wjh.v5.i4.94 2218-6204 |
| url |
https://hdl.handle.net/10495/44926 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
World. J. Hematol. |
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98 |
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4 |
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94 |
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5 |
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World Journal of Hematology |
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5 páginas |
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Baishideng Publishing Group |
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Pleasanton, Estados Unidos |
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Universidad de Antioquia |
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Posso Zapata, Carolina MaríaCuéllar Ambrosi, FranciscoGrupo de Investigación en Cirugía Plástica Universidad de Antioquia2025-02-16T20:07:18Z2025-02-16T20:07:18Z2016Posso C, Cuéllar-Ambrosi F. Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case report. World J Hematol 2016; 5(4): 94-98 DOI: 10.5315/wjh.v5.i4.94https://hdl.handle.net/10495/4492610.5315/wjh.v5.i4.942218-6204ABSTRACT: We present an 18-year-old female with sickle cell disease, who presented with an extensive lower leg ulcer over a 12-year course of the disease. Definitive reconstruction was made using a free latissimus dorsi flap and split-skin grafts. One week before the surgery, the plasmapheresis protocol and blood transfusion were administered, in order to achieve a hemoglobin S level of ≤ 30%. Intraoperatively, the flap pedicle was rinsed with plasminogen activator inhibitor-1 until the thrombolytic agent was obtained from the comitant vein; after the arterial flow had been released, an intravenous bolus dose of heparin (2000 U) was administrated. No vascular complications occurred. Postoperatively, the patient received a 10-d course of hemodilution and a 14-d course of full-dose anticoagulation. After 8 mo postoperatively, the patient was able to walk and run, and showed complete wound healing. This case indicates that sickle cell disease is not a contraindication to free tissue transfer; however, the complications, their rate and overall outcomes for these cases are not yet clear. Herein, we provide an algorithm based on our clinical experience in this type of case and treatment, including several recommendations that may help to reduce thrombosis risk and systemic complications.COL00383065 páginasapplication/pdfengBaishideng Publishing GroupPleasanton, Estados Unidoshttps://creativecommons.org/licenses/by-nc/4.0/http://creativecommons.org/licenses/by-nc/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Successful lower leg microsurgical reconstruction in homozygous sickle cell disease: Case reportReporte de casohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTCASOhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionColgajos Tisulares LibresFree Tissue FlapsAnemia de Células FalciformesAnemia, Sickle CellÚlceraUlcerhttps://id.nlm.nih.gov/mesh/D058752https://id.nlm.nih.gov/mesh/D000755https://id.nlm.nih.gov/mesh/D014456World. J. 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