Antiprotozoal 6-substituted-5,6-dihydro-alpha-pyrones from Raimondia cf. monoica.

ABSTRACT: Dichloromethane extracts of both the roots and the leaves of Raimondia cf. monoica showed in vitro antiplasmodial and leishmanicidal activities against Plasmodium falciparum and Leishmania panamensis, respectively. Three 6-substituted 5,6-dihydro-2H-pyran-2-ones were isolated. (1) and (2) were identified as (6S)-(5′-oxohepten-1′E,3′E-dienyl)-5,6-dihydro-2H-pyran-2-one (1) and (6R)-(5′-oxohepten-1′Z,3′E-dienyl)-5,6-dihydro-2H-pyran-2-one (2), respectively. (-)-Argentilactone (3) was also isolated. The structure of the new compound (1) was determined by spectroscopic methods; additional spectroscopic data for (2) are reported for the first time

• Autores: Carmona Pedraza, Doris; Sáez Vega, Jairo Antonio; Granados Niño, Hillmer; Pérez Hernández, Edwin Gregorio; Blair Trujillo, Silvia; Angulo Soto, Alberto; Figadere, Bruno
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2003
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/37256
• Acceso en línea: https://hdl.handle.net/10495/37256
• Palabra clave: Annonaceae; Antiprotozoarios; Antiprotozoal Agents; Lactonas; Lactones; Leishmania; Estructura Molecular; Molecular Structure; Hojas de la Planta; Plant Leaves; Raíces de Plantas; Plant Roots; Plasmodium falciparum; Pironas; Pyrones; Malaria
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc/2.5/co/