The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti

ABSTRACT: Zika virus (ZIKV) is causing an explosive outbreak of febrile disease in the Americas. There are no effective antiviral therapies or licensed vaccines for this virus and mosquito control strategies have not been adequate to contain the virus. A promising candidate for arbovirus control and...

Full description

Autores:
Vélez Bernal, Iván Darío
Peinado, Stephen
Osorio Benitez, Jorge Emilio
Aliota, Matthew T.
Tipo de recurso:
Investigation report
Fecha de publicación:
2016
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/36547
Acceso en línea:
https://hdl.handle.net/10495/36547
Palabra clave:
Aedes
Chlorocebus aethiops
Interacciones Huésped-Patógeno
Host-Pathogen Interactions
Insectos Vectores
Insect Vectors
Control Biológico de Vectores
Pest Control, Biological
Células Vero
Vero Cells
Wolbachia
Infección por el Virus Zika
Zika Virus Infection
Virosis
Virus Diseases
Rights
openAccess
License
https://creativecommons.org/licenses/by/4.0/
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network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti
title The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti
spellingShingle The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti
Aedes
Chlorocebus aethiops
Interacciones Huésped-Patógeno
Host-Pathogen Interactions
Insectos Vectores
Insect Vectors
Control Biológico de Vectores
Pest Control, Biological
Células Vero
Vero Cells
Wolbachia
Infección por el Virus Zika
Zika Virus Infection
Virosis
Virus Diseases
title_short The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti
title_full The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti
title_fullStr The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti
title_full_unstemmed The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti
title_sort The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti
dc.creator.fl_str_mv Vélez Bernal, Iván Darío
Peinado, Stephen
Osorio Benitez, Jorge Emilio
Aliota, Matthew T.
dc.contributor.author.none.fl_str_mv Vélez Bernal, Iván Darío
Peinado, Stephen
Osorio Benitez, Jorge Emilio
Aliota, Matthew T.
dc.contributor.researchgroup.spa.fl_str_mv Programa de Estudio y Control de Enfermedades Tropicales (PECET)
dc.subject.decs.none.fl_str_mv Aedes
Chlorocebus aethiops
Interacciones Huésped-Patógeno
Host-Pathogen Interactions
Insectos Vectores
Insect Vectors
Control Biológico de Vectores
Pest Control, Biological
Células Vero
Vero Cells
Wolbachia
Infección por el Virus Zika
Zika Virus Infection
Virosis
Virus Diseases
topic Aedes
Chlorocebus aethiops
Interacciones Huésped-Patógeno
Host-Pathogen Interactions
Insectos Vectores
Insect Vectors
Control Biológico de Vectores
Pest Control, Biological
Células Vero
Vero Cells
Wolbachia
Infección por el Virus Zika
Zika Virus Infection
Virosis
Virus Diseases
description ABSTRACT: Zika virus (ZIKV) is causing an explosive outbreak of febrile disease in the Americas. There are no effective antiviral therapies or licensed vaccines for this virus and mosquito control strategies have not been adequate to contain the virus. A promising candidate for arbovirus control and prevention relies on the introduction of the intracellular bacterium Wolbachia into Aedes aegypti mosquitoes. This primarily has been proposed as a tool to control dengue virus (DENV) transmission; however, evidence suggests Wolbachia infections confer protection for Ae. aegypti against other arboviruses. At present, it is unknown whether or not ZIKV can infect, disseminate and be transmitted by Wolbachia-infected Ae. aegypti. Using Ae. aegypti infected with the wMel strain of Wolbachia that are being released in Medellin, Colombia, we report that these mosquitoes have reduced vector competence for ZIKV. These results support the use of Wolbachia biocontrol as a multivalent strategy against Ae. aegypti-transmitted viruses.
publishDate 2016
dc.date.issued.none.fl_str_mv 2016
dc.date.accessioned.none.fl_str_mv 2023-09-04T18:44:24Z
dc.date.available.none.fl_str_mv 2023-09-04T18:44:24Z
dc.type.spa.fl_str_mv Informe de investigación
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dc.identifier.citation.spa.fl_str_mv Aliota, M. T., Peinado, S. A., Velez, I. D., & Osorio, J. E. (2016). The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti. Scientific reports, 6, 28792. https://doi.org/10.1038/srep28792
dc.identifier.issn.none.fl_str_mv 2045-2322
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/36547
dc.identifier.doi.none.fl_str_mv 10.1038/srep28792
identifier_str_mv Aliota, M. T., Peinado, S. A., Velez, I. D., & Osorio, J. E. (2016). The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti. Scientific reports, 6, 28792. https://doi.org/10.1038/srep28792
2045-2322
10.1038/srep28792
url https://hdl.handle.net/10495/36547
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Sci. Rep.
dc.relation.citationendpage.spa.fl_str_mv 7
dc.relation.citationissue.spa.fl_str_mv 28792
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dc.relation.citationvolume.spa.fl_str_mv 6
dc.relation.ispartofjournal.spa.fl_str_mv Scientific Reports
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spelling Vélez Bernal, Iván DaríoPeinado, StephenOsorio Benitez, Jorge EmilioAliota, Matthew T.Programa de Estudio y Control de Enfermedades Tropicales (PECET)2023-09-04T18:44:24Z2023-09-04T18:44:24Z2016Aliota, M. T., Peinado, S. A., Velez, I. D., & Osorio, J. E. (2016). The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegypti. Scientific reports, 6, 28792. https://doi.org/10.1038/srep287922045-2322https://hdl.handle.net/10495/3654710.1038/srep28792ABSTRACT: Zika virus (ZIKV) is causing an explosive outbreak of febrile disease in the Americas. There are no effective antiviral therapies or licensed vaccines for this virus and mosquito control strategies have not been adequate to contain the virus. A promising candidate for arbovirus control and prevention relies on the introduction of the intracellular bacterium Wolbachia into Aedes aegypti mosquitoes. This primarily has been proposed as a tool to control dengue virus (DENV) transmission; however, evidence suggests Wolbachia infections confer protection for Ae. aegypti against other arboviruses. At present, it is unknown whether or not ZIKV can infect, disseminate and be transmitted by Wolbachia-infected Ae. aegypti. Using Ae. aegypti infected with the wMel strain of Wolbachia that are being released in Medellin, Colombia, we report that these mosquitoes have reduced vector competence for ZIKV. These results support the use of Wolbachia biocontrol as a multivalent strategy against Ae. aegypti-transmitted viruses.COL00150997application/pdfengNature Publishing GroupLondres, Inglaterrahttps://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2The wMel strain of Wolbachia Reduces Transmission of Zika virus by Aedes aegyptiInforme de investigaciónhttp://purl.org/coar/resource_type/c_18wshttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/INFhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionAedesChlorocebus aethiopsInteracciones Huésped-PatógenoHost-Pathogen InteractionsInsectos VectoresInsect VectorsControl Biológico de VectoresPest Control, BiologicalCélulas VeroVero CellsWolbachiaInfección por el Virus ZikaZika Virus InfectionVirosisVirus DiseasesSci. 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