Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model
ABSTRACT: Alzheimer’s disease is the most common form of dementia. It is characterized by histopathological hallmarks such as senile plaques and neurofibrillary tangles, as well as a concomitant activation of microglial cells and astrocytes that release pro-inflammatory mediators such as IL-1β, iNOS...
- Autores:
-
Sabogal Guáqueta, Angélica María
Cardona Gómez, Gloria Patricia
Vargas Restrepo, Felipe
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/36523
- Acceso en línea:
- https://hdl.handle.net/10495/36523
- Palabra clave:
- Enfermedad de Alzheimer
Alzheimer Disease
Quercetina
Quercetin
Microglía
Astrocitos
Astrocytes
Demencia
Dementia
Región CA1 Hipocampal
CA1 Region, Hippocampal
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-nd/4.0/
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| dc.title.spa.fl_str_mv |
Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model |
| dc.title.translated.spa.fl_str_mv |
La quercetina disminuye la inflamación en la región CA1 del hipocampo en un modelo de ratón triple transgénico para la enfermedad de Alzheimer |
| title |
Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model |
| spellingShingle |
Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model Enfermedad de Alzheimer Alzheimer Disease Quercetina Quercetin Microglía Astrocitos Astrocytes Demencia Dementia Región CA1 Hipocampal CA1 Region, Hippocampal |
| title_short |
Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model |
| title_full |
Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model |
| title_fullStr |
Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model |
| title_full_unstemmed |
Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model |
| title_sort |
Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model |
| dc.creator.fl_str_mv |
Sabogal Guáqueta, Angélica María Cardona Gómez, Gloria Patricia Vargas Restrepo, Felipe |
| dc.contributor.author.none.fl_str_mv |
Sabogal Guáqueta, Angélica María Cardona Gómez, Gloria Patricia Vargas Restrepo, Felipe |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Neurociencias de Antioquia |
| dc.subject.decs.none.fl_str_mv |
Enfermedad de Alzheimer Alzheimer Disease Quercetina Quercetin Microglía Astrocitos Astrocytes Demencia Dementia Región CA1 Hipocampal CA1 Region, Hippocampal |
| topic |
Enfermedad de Alzheimer Alzheimer Disease Quercetina Quercetin Microglía Astrocitos Astrocytes Demencia Dementia Región CA1 Hipocampal CA1 Region, Hippocampal |
| description |
ABSTRACT: Alzheimer’s disease is the most common form of dementia. It is characterized by histopathological hallmarks such as senile plaques and neurofibrillary tangles, as well as a concomitant activation of microglial cells and astrocytes that release pro-inflammatory mediators such as IL-1β, iNOS, and COX-2, leading to neuronal dysfunction and death. |
| publishDate |
2018 |
| dc.date.issued.none.fl_str_mv |
2018 |
| dc.date.accessioned.none.fl_str_mv |
2023-09-04T13:44:58Z |
| dc.date.available.none.fl_str_mv |
2023-09-04T13:44:58Z |
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Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Olave AM, Mesa JA, Botero JH, Patiño EB, García GM, Alzate JF. Producción y evaluación del antígeno recombinante TES-30 de Toxocara canis para el inmunodiagnóstico de toxocariasis. biomedica [Internet]. 1 de marzo de 2016 [citado 28 de marzo de 2024];36(1):39-51. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/2617 |
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0120-4157 |
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https://hdl.handle.net/10495/36523 |
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10.7705/biomedica.v38i0.3761 |
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2590-7379 |
| identifier_str_mv |
Olave AM, Mesa JA, Botero JH, Patiño EB, García GM, Alzate JF. Producción y evaluación del antígeno recombinante TES-30 de Toxocara canis para el inmunodiagnóstico de toxocariasis. biomedica [Internet]. 1 de marzo de 2016 [citado 28 de marzo de 2024];36(1):39-51. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/2617 0120-4157 10.7705/biomedica.v38i0.3761 2590-7379 |
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https://hdl.handle.net/10495/36523 |
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eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Biomédica |
| dc.relation.citationendpage.spa.fl_str_mv |
69 |
| dc.relation.citationissue.spa.fl_str_mv |
Suplemento 1 |
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62 |
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38 |
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Biomédica |
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Instituto Nacional de Salud |
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Bogotá, Colombia |
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Universidad de Antioquia |
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Sabogal Guáqueta, Angélica MaríaCardona Gómez, Gloria PatriciaVargas Restrepo, FelipeGrupo de Neurociencias de Antioquia2023-09-04T13:44:58Z2023-09-04T13:44:58Z2018Olave AM, Mesa JA, Botero JH, Patiño EB, García GM, Alzate JF. Producción y evaluación del antígeno recombinante TES-30 de Toxocara canis para el inmunodiagnóstico de toxocariasis. biomedica [Internet]. 1 de marzo de 2016 [citado 28 de marzo de 2024];36(1):39-51. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/26170120-4157https://hdl.handle.net/10495/3652310.7705/biomedica.v38i0.37612590-7379ABSTRACT: Alzheimer’s disease is the most common form of dementia. It is characterized by histopathological hallmarks such as senile plaques and neurofibrillary tangles, as well as a concomitant activation of microglial cells and astrocytes that release pro-inflammatory mediators such as IL-1β, iNOS, and COX-2, leading to neuronal dysfunction and death.RESUMEN: La enfermedad de Alzheimer es la forma más común de demencia; se caracteriza por la presencia de marcadores histopatológicos, como las placas seniles y los ovillos neurofibrilares, así como por una activación concomitante de células microgliales y astrocitos que liberan mediadores proinflamatorios, como IL-1β, iNOS y COX-2, lo cual conduce a la disfunción y la muerte neuronal.Ministerio de Ciencia, Tecnología e InnovaciónUniversidad de Antioquia. Vicerrectoría de investigación. Comité para el Desarrollo de la Investigación - CODICOL00107448application/pdfengInstituto Nacional de SaludBogotá, Colombiahttps://creativecommons.org/licenses/by-nc-nd/4.0/http://creativecommons.org/licenses/by-nc-nd/2.5/co/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice modelLa quercetina disminuye la inflamación en la región CA1 del hipocampo en un modelo de ratón triple transgénico para la enfermedad de AlzheimerArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionEnfermedad de AlzheimerAlzheimer DiseaseQuercetinaQuercetinMicroglíaAstrocitosAstrocytesDemenciaDementiaRegión CA1 HipocampalCA1 Region, HippocampalBiomédica69Suplemento 16238Biomédica111551928905(2011e2012) (AM S-G)RoR: 048jthh02RoR: 03bp5hc83PublicationCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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