Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomy

ABSTRACT: Introduction: Thyroidectomy is a common surgery. Routine searching of the recurrent laryngeal nerve is the most important strategy to avoid palsy. Neuromonitoring has been recommended to decrease recurrent laryngeal nerve palsy. Objective: To assess if neuromonitoring of recurrent laryngea...

Full description

Autores:
Sanabria Quiroga, Álvaro Enrique
Ramírez Cuellar, Adonis Tupac
Tipo de recurso:
Article of investigation
Fecha de publicación:
2015
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/43073
Acceso en línea:
https://hdl.handle.net/10495/43073
Palabra clave:
Cost-Benefit Analysis
Análisis Costo-Beneficio
Decision Support Techniques
Técnicas de Apoyo para la Decisión
Developing Countries
Países en Desarrollo
Electric Stimulation
Estimulación Eléctrica
Electromyography
Electromiografía
Intraoperative Complications
Complicaciones Intraoperatorias
Intraoperative Neurophysiological Monitoring
Monitorización Neurofisiológica Intraoperatoria
Intubation, Intratracheal
Intubación Intratraqueal
Length of Stay
Tiempo de Internación
Meta-Analysis as Topic
Metaanálisis como Asunto
Probability
Probabilidad
Recurrent Laryngeal Nerve
Nervio Laríngeo Recurrente
Thyroidectomy
Tiroidectomía
Tracheostomy
Traqueostomía
https://id.nlm.nih.gov/mesh/D003362
https://id.nlm.nih.gov/mesh/D003661
https://id.nlm.nih.gov/mesh/D003906
https://id.nlm.nih.gov/mesh/D004558
https://id.nlm.nih.gov/mesh/D004576
https://id.nlm.nih.gov/mesh/D007431
https://id.nlm.nih.gov/mesh/D064795
https://id.nlm.nih.gov/mesh/D007442
https://id.nlm.nih.gov/mesh/D007902
https://id.nlm.nih.gov/mesh/D015201
https://id.nlm.nih.gov/mesh/D011336
https://id.nlm.nih.gov/mesh/D012009
https://id.nlm.nih.gov/mesh/D013965
https://id.nlm.nih.gov/mesh/D014139
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UDEA2_c274eaab3692b12a5b73e79d9c2cdbdd
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/43073
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomy
dc.title.translated.spa.fl_str_mv Análisis económico de la monitorización neurológica rutinaria del nervio laríngeo recurrente en la tiroidectomía total
title Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomy
spellingShingle Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomy
Cost-Benefit Analysis
Análisis Costo-Beneficio
Decision Support Techniques
Técnicas de Apoyo para la Decisión
Developing Countries
Países en Desarrollo
Electric Stimulation
Estimulación Eléctrica
Electromyography
Electromiografía
Intraoperative Complications
Complicaciones Intraoperatorias
Intraoperative Neurophysiological Monitoring
Monitorización Neurofisiológica Intraoperatoria
Intubation, Intratracheal
Intubación Intratraqueal
Length of Stay
Tiempo de Internación
Meta-Analysis as Topic
Metaanálisis como Asunto
Probability
Probabilidad
Recurrent Laryngeal Nerve
Nervio Laríngeo Recurrente
Thyroidectomy
Tiroidectomía
Tracheostomy
Traqueostomía
https://id.nlm.nih.gov/mesh/D003362
https://id.nlm.nih.gov/mesh/D003661
https://id.nlm.nih.gov/mesh/D003906
https://id.nlm.nih.gov/mesh/D004558
https://id.nlm.nih.gov/mesh/D004576
https://id.nlm.nih.gov/mesh/D007431
https://id.nlm.nih.gov/mesh/D064795
https://id.nlm.nih.gov/mesh/D007442
https://id.nlm.nih.gov/mesh/D007902
https://id.nlm.nih.gov/mesh/D015201
https://id.nlm.nih.gov/mesh/D011336
https://id.nlm.nih.gov/mesh/D012009
https://id.nlm.nih.gov/mesh/D013965
https://id.nlm.nih.gov/mesh/D014139
title_short Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomy
title_full Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomy
title_fullStr Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomy
title_full_unstemmed Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomy
title_sort Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomy
dc.creator.fl_str_mv Sanabria Quiroga, Álvaro Enrique
Ramírez Cuellar, Adonis Tupac
dc.contributor.author.none.fl_str_mv Sanabria Quiroga, Álvaro Enrique
Ramírez Cuellar, Adonis Tupac
dc.contributor.researchgroup.spa.fl_str_mv Trauma y Cirugía
dc.subject.decs.none.fl_str_mv Cost-Benefit Analysis
Análisis Costo-Beneficio
Decision Support Techniques
Técnicas de Apoyo para la Decisión
Developing Countries
Países en Desarrollo
Electric Stimulation
Estimulación Eléctrica
Electromyography
Electromiografía
Intraoperative Complications
Complicaciones Intraoperatorias
Intraoperative Neurophysiological Monitoring
Monitorización Neurofisiológica Intraoperatoria
Intubation, Intratracheal
Intubación Intratraqueal
Length of Stay
Tiempo de Internación
Meta-Analysis as Topic
Metaanálisis como Asunto
Probability
Probabilidad
Recurrent Laryngeal Nerve
Nervio Laríngeo Recurrente
Thyroidectomy
Tiroidectomía
Tracheostomy
Traqueostomía
topic Cost-Benefit Analysis
Análisis Costo-Beneficio
Decision Support Techniques
Técnicas de Apoyo para la Decisión
Developing Countries
Países en Desarrollo
Electric Stimulation
Estimulación Eléctrica
Electromyography
Electromiografía
Intraoperative Complications
Complicaciones Intraoperatorias
Intraoperative Neurophysiological Monitoring
Monitorización Neurofisiológica Intraoperatoria
Intubation, Intratracheal
Intubación Intratraqueal
Length of Stay
Tiempo de Internación
Meta-Analysis as Topic
Metaanálisis como Asunto
Probability
Probabilidad
Recurrent Laryngeal Nerve
Nervio Laríngeo Recurrente
Thyroidectomy
Tiroidectomía
Tracheostomy
Traqueostomía
https://id.nlm.nih.gov/mesh/D003362
https://id.nlm.nih.gov/mesh/D003661
https://id.nlm.nih.gov/mesh/D003906
https://id.nlm.nih.gov/mesh/D004558
https://id.nlm.nih.gov/mesh/D004576
https://id.nlm.nih.gov/mesh/D007431
https://id.nlm.nih.gov/mesh/D064795
https://id.nlm.nih.gov/mesh/D007442
https://id.nlm.nih.gov/mesh/D007902
https://id.nlm.nih.gov/mesh/D015201
https://id.nlm.nih.gov/mesh/D011336
https://id.nlm.nih.gov/mesh/D012009
https://id.nlm.nih.gov/mesh/D013965
https://id.nlm.nih.gov/mesh/D014139
dc.subject.meshuri.none.fl_str_mv https://id.nlm.nih.gov/mesh/D003362
https://id.nlm.nih.gov/mesh/D003661
https://id.nlm.nih.gov/mesh/D003906
https://id.nlm.nih.gov/mesh/D004558
https://id.nlm.nih.gov/mesh/D004576
https://id.nlm.nih.gov/mesh/D007431
https://id.nlm.nih.gov/mesh/D064795
https://id.nlm.nih.gov/mesh/D007442
https://id.nlm.nih.gov/mesh/D007902
https://id.nlm.nih.gov/mesh/D015201
https://id.nlm.nih.gov/mesh/D011336
https://id.nlm.nih.gov/mesh/D012009
https://id.nlm.nih.gov/mesh/D013965
https://id.nlm.nih.gov/mesh/D014139
description ABSTRACT: Introduction: Thyroidectomy is a common surgery. Routine searching of the recurrent laryngeal nerve is the most important strategy to avoid palsy. Neuromonitoring has been recommended to decrease recurrent laryngeal nerve palsy. Objective: To assess if neuromonitoring of recurrent laryngeal nerve during thyroidectomy is cost-effective in a developing country. Materials and methods: We designed a decision analysis to assess the cost-effectiveness of recurrent laryngeal nerve neuromonitoring. For probabilities, we used data from a meta-analysis. Utility was measured using preference values. We considered direct costs. We conducted a deterministic and a probabilistic analysis. Results: We did not find differences in utility between arms. The frequency of recurrent laryngeal nerve injury was 1% in the neuromonitor group and 1.6% for the standard group. Thyroidectomy without monitoring was the less expensive alternative. The incremental cost-effectiveness ratio was COP$ 9,112,065. Conclusion: Routine neuromonitoring in total thyroidectomy with low risk of recurrent laryngeal nerve injury is neither cost-useful nor cost-effective in the Colombian health system.
publishDate 2015
dc.date.issued.none.fl_str_mv 2015
dc.date.accessioned.none.fl_str_mv 2024-11-03T04:06:18Z
dc.date.available.none.fl_str_mv 2024-11-03T04:06:18Z
dc.type.spa.fl_str_mv Artículo de investigación
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/ART
dc.type.coarversion.spa.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.citation.spa.fl_str_mv Sanabria Álvaro, Ramírez A. Análisis económico de la monitorización neurológica rutinaria del nervio laríngeo recurrente en la tiroidectomía total. Biomed. [Internet]. 1 de septiembre de 2015 [citado 2 de noviembre de 2024];35(3):363-71. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/2371
dc.identifier.issn.none.fl_str_mv 0120-4157
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/43073
dc.identifier.doi.none.fl_str_mv 10.7705/biomedica.v35i3.2371
dc.identifier.eissn.none.fl_str_mv 2590-7379
identifier_str_mv Sanabria Álvaro, Ramírez A. Análisis económico de la monitorización neurológica rutinaria del nervio laríngeo recurrente en la tiroidectomía total. Biomed. [Internet]. 1 de septiembre de 2015 [citado 2 de noviembre de 2024];35(3):363-71. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/2371
0120-4157
10.7705/biomedica.v35i3.2371
2590-7379
url https://hdl.handle.net/10495/43073
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Biomédica
dc.relation.citationendpage.spa.fl_str_mv 371
dc.relation.citationissue.spa.fl_str_mv 3
dc.relation.citationstartpage.spa.fl_str_mv 363
dc.relation.citationvolume.spa.fl_str_mv 35
dc.relation.ispartofjournal.spa.fl_str_mv Biomédica
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
https://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.spa.fl_str_mv 9 páginas
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Instituto Nacional de Salud
dc.publisher.place.spa.fl_str_mv Bogotá, Colombia
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstreams/465d69c9-6f00-43ea-b98f-bc497e3413d6/download
https://bibliotecadigital.udea.edu.co/bitstreams/93ef61d5-46f8-4552-b0f9-29231a53d502/download
https://bibliotecadigital.udea.edu.co/bitstreams/06057d46-f8ae-484d-8236-e4a1860ae869/download
https://bibliotecadigital.udea.edu.co/bitstreams/b67d8ea1-386b-4aa1-a98d-7b6eec005b32/download
bitstream.checksum.fl_str_mv 8a4605be74aa9ea9d79846c1fba20a33
d5a064eacba7a0449b021b3baab684da
77605275e041d5e7c40183fa4279ecd1
d237dabb6459651f58248ba552cabef9
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional de la Universidad de Antioquia
repository.mail.fl_str_mv aplicacionbibliotecadigitalbiblioteca@udea.edu.co
_version_ 1851052612275666944
spelling Sanabria Quiroga, Álvaro EnriqueRamírez Cuellar, Adonis TupacTrauma y Cirugía2024-11-03T04:06:18Z2024-11-03T04:06:18Z2015Sanabria Álvaro, Ramírez A. Análisis económico de la monitorización neurológica rutinaria del nervio laríngeo recurrente en la tiroidectomía total. Biomed. [Internet]. 1 de septiembre de 2015 [citado 2 de noviembre de 2024];35(3):363-71. Disponible en: https://revistabiomedica.org/index.php/biomedica/article/view/23710120-4157https://hdl.handle.net/10495/4307310.7705/biomedica.v35i3.23712590-7379ABSTRACT: Introduction: Thyroidectomy is a common surgery. Routine searching of the recurrent laryngeal nerve is the most important strategy to avoid palsy. Neuromonitoring has been recommended to decrease recurrent laryngeal nerve palsy. Objective: To assess if neuromonitoring of recurrent laryngeal nerve during thyroidectomy is cost-effective in a developing country. Materials and methods: We designed a decision analysis to assess the cost-effectiveness of recurrent laryngeal nerve neuromonitoring. For probabilities, we used data from a meta-analysis. Utility was measured using preference values. We considered direct costs. We conducted a deterministic and a probabilistic analysis. Results: We did not find differences in utility between arms. The frequency of recurrent laryngeal nerve injury was 1% in the neuromonitor group and 1.6% for the standard group. Thyroidectomy without monitoring was the less expensive alternative. The incremental cost-effectiveness ratio was COP$ 9,112,065. Conclusion: Routine neuromonitoring in total thyroidectomy with low risk of recurrent laryngeal nerve injury is neither cost-useful nor cost-effective in the Colombian health system.RESUMEN: Introducción. La tiroidectomía es una cirugía común. La búsqueda rutinaria del nervio laríngeo inferior es la estrategia más importante para evitar la parálisis. Objetivo. Evaluar el costo-efectividad en un país en desarrollo de la monitorización neurológica del nervio laríngeo inferior durante la tiroidectomía. Materiales y métodos. Se diseñó un análisis de decisiones para evaluar el costo-efectividad de la monitorización neurológica del nervio laríngeo inferior. Para las probabilidades se usaron datos de un metaanálisis. La utilidad se determinó con medidas de preferencia. Se incluyeron los costos directos. Se hizo un análisis determinístico y probabilístico. Resultados. No se encontraron diferencias en la utilidad entre las estrategias. La frecuencia de la lesión de este nervio fue de 1 % en el grupo bajo monitorización neurológica y de 1,6 % en el grupo de control. La tiroidectomía sin monitorización fue la alternativa menos costosa. La razón de costo-efectividad incremental fue de COP$ 9.112.065 Conclusión. La monitorización neurológica rutinaria en la tiroidectomía total con bajo riesgo de lesión del nervio laríngeo inferior, no es útil con relación a su costo ni costo-efectiva en el sistema de salud colombiano.COL00166129 páginasapplication/pdfengInstituto Nacional de SaludBogotá, Colombiahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Economic analysis of routine neuromonitoring of recurrent laryngeal nerve in total thyroidectomyAnálisis económico de la monitorización neurológica rutinaria del nervio laríngeo recurrente en la tiroidectomía totalArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionCost-Benefit AnalysisAnálisis Costo-BeneficioDecision Support TechniquesTécnicas de Apoyo para la DecisiónDeveloping CountriesPaíses en DesarrolloElectric StimulationEstimulación EléctricaElectromyographyElectromiografíaIntraoperative ComplicationsComplicaciones IntraoperatoriasIntraoperative Neurophysiological MonitoringMonitorización Neurofisiológica IntraoperatoriaIntubation, IntratrachealIntubación IntratraquealLength of StayTiempo de InternaciónMeta-Analysis as TopicMetaanálisis como AsuntoProbabilityProbabilidadRecurrent Laryngeal NerveNervio Laríngeo RecurrenteThyroidectomyTiroidectomíaTracheostomyTraqueostomíahttps://id.nlm.nih.gov/mesh/D003362https://id.nlm.nih.gov/mesh/D003661https://id.nlm.nih.gov/mesh/D003906https://id.nlm.nih.gov/mesh/D004558https://id.nlm.nih.gov/mesh/D004576https://id.nlm.nih.gov/mesh/D007431https://id.nlm.nih.gov/mesh/D064795https://id.nlm.nih.gov/mesh/D007442https://id.nlm.nih.gov/mesh/D007902https://id.nlm.nih.gov/mesh/D015201https://id.nlm.nih.gov/mesh/D011336https://id.nlm.nih.gov/mesh/D012009https://id.nlm.nih.gov/mesh/D013965https://id.nlm.nih.gov/mesh/D014139Biomédica371336335BiomédicaPublicationLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/465d69c9-6f00-43ea-b98f-bc497e3413d6/download8a4605be74aa9ea9d79846c1fba20a33MD52falseAnonymousREADORIGINALSanabriaAlvaro_2015_Economic_Analysis_Routine.pdfSanabriaAlvaro_2015_Economic_Analysis_Routine.pdfArtículo de investigaciónapplication/pdf412919https://bibliotecadigital.udea.edu.co/bitstreams/93ef61d5-46f8-4552-b0f9-29231a53d502/downloadd5a064eacba7a0449b021b3baab684daMD51trueAnonymousREADTEXTSanabriaAlvaro_2015_Economic_Analysis_Routine.pdf.txtSanabriaAlvaro_2015_Economic_Analysis_Routine.pdf.txtExtracted texttext/plain36948https://bibliotecadigital.udea.edu.co/bitstreams/06057d46-f8ae-484d-8236-e4a1860ae869/download77605275e041d5e7c40183fa4279ecd1MD53falseAnonymousREADTHUMBNAILSanabriaAlvaro_2015_Economic_Analysis_Routine.pdf.jpgSanabriaAlvaro_2015_Economic_Analysis_Routine.pdf.jpgGenerated Thumbnailimage/jpeg14108https://bibliotecadigital.udea.edu.co/bitstreams/b67d8ea1-386b-4aa1-a98d-7b6eec005b32/downloadd237dabb6459651f58248ba552cabef9MD54falseAnonymousREAD10495/43073oai:bibliotecadigital.udea.edu.co:10495/430732025-03-27 01:03:59.401http://creativecommons.org/licenses/by-nc-nd/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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