Metformin protects against diclofenac-induced toxicity in primary rat hepatocytes by preserving mitochondrial integrity via a pathway involving EPAC

ABSTRACT: Background and purpose: It has been shown that the antidiabetic drug metformin protects hepatocytes against toxicity by various stressors. Chronic or excessive consumption of diclofenac (DF) - a pain-relieving drug, leads to drug-induced liver injury via a mechanism involving mitochondrial...

Full description

Autores:

Arroyave Ospina, Johanna Carolina
Aguilar Mora, Fabio Alejandro
Musheshe, Nshunge
Geng, Yana
Soto, Juan M.
Rodrigo, José A.
Alieva, Tatiana
Buist Homan, Manon
Lezoualc'h, Frank
Cheng, Xiaodong
Schmidt, Martina
Moshage, Han

Tipo de recurso:

Article of investigation

Fecha de publicación:

2021

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/40154

Acceso en línea:

https://hdl.handle.net/10495/40154

Palabra clave:

Antioxidantes
Antioxidants
Apoptosis
Apoptosis
Caspasa 3
Caspase 3
Células Cultivadas
Cells, Cultured
Enfermedad Hepática Inducida por Sustancias y Drogas
Chemical and Drug Induced Liver Injury
AMP Cíclico
Cyclic AMP
Inhibidores de la Ciclooxigenasa
Cyclooxygenase Inhibitors
Diclofenaco
Diclofenac
Factores de Intercambio de Guanina Nucleótido
Guanine Nucleotide Exchange Factors
Hepatocitos
Hepatocytes
Metformina
Metformin
Mitocondrias Hepáticas
Mitochondria, Liver
Estrés Oxidativo
Oxidative Stress
Cultivo Primario de Células
Primary Cell Culture
Ratas Wistar
Rats, Wistar
https://id.nlm.nih.gov/mesh/D022781
https://id.nlm.nih.gov/mesh/D000975
https://id.nlm.nih.gov/mesh/D017209
https://id.nlm.nih.gov/mesh/D053148
https://id.nlm.nih.gov/mesh/D002478
https://id.nlm.nih.gov/mesh/D056486
https://id.nlm.nih.gov/mesh/D000242
https://id.nlm.nih.gov/mesh/D016861
https://id.nlm.nih.gov/mesh/D004008
https://id.nlm.nih.gov/mesh/D020662
https://id.nlm.nih.gov/mesh/D008687
https://id.nlm.nih.gov/mesh/D008930
https://id.nlm.nih.gov/mesh/D018384
https://id.nlm.nih.gov/mesh/D061251
https://id.nlm.nih.gov/mesh/D017208

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/