Progesterone effects on mouse sperm kinetics in conditions of viscosity
ABSTRACT: The spermatozoa delivered to the female genital tract need to swim towards the oocyte through viscous secretions. Once close to the oocyte, the spermatozoa are guided by a gradient of progesterone (P4) and other unknown chemoattractants via a process known as chemotaxis. Using polyvinylpyr...
- Autores:
-
López Cardona, Angela Patricia
Pérez Cerezales, Serafín
Gutiérrez Adán, Alfonso
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/37520
- Acceso en línea:
- https://hdl.handle.net/10495/37520
- Palabra clave:
- Reacción Acrosómica
Acrosome Reaction
Factores Quimiotácticos - farmacología
Chemotactic Factors - pharmacology
Quimiotaxis - efectos de los fármacos
Chemotaxis - drug effects
Cinética
Kinetics
Espermatozoides - efectos de los fármacos
Spermatozoa - drug effects
Motilidad Espermática - efectos de los fármacos
Sperm Motility - drug effects
Ratones Endogámicos C57BL
Mice, Inbred C57BL
Progesterona
Progesterone
http://id.nlm.nih.gov/mesh/D020101
http://id.nlm.nih.gov/mesh/D000818
http://id.nlm.nih.gov/mesh/D002630
http://id.nlm.nih.gov/mesh/D002633
http://id.nlm.nih.gov/mesh/D005260
http://id.nlm.nih.gov/mesh/D007700
http://id.nlm.nih.gov/mesh/D008810
http://id.nlm.nih.gov/mesh/D011374
http://id.nlm.nih.gov/mesh/D013081
http://id.nlm.nih.gov/mesh/D013094
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
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| dc.title.spa.fl_str_mv |
Progesterone effects on mouse sperm kinetics in conditions of viscosity |
| title |
Progesterone effects on mouse sperm kinetics in conditions of viscosity |
| spellingShingle |
Progesterone effects on mouse sperm kinetics in conditions of viscosity Reacción Acrosómica Acrosome Reaction Factores Quimiotácticos - farmacología Chemotactic Factors - pharmacology Quimiotaxis - efectos de los fármacos Chemotaxis - drug effects Cinética Kinetics Espermatozoides - efectos de los fármacos Spermatozoa - drug effects Motilidad Espermática - efectos de los fármacos Sperm Motility - drug effects Ratones Endogámicos C57BL Mice, Inbred C57BL Progesterona Progesterone http://id.nlm.nih.gov/mesh/D020101 http://id.nlm.nih.gov/mesh/D000818 http://id.nlm.nih.gov/mesh/D002630 http://id.nlm.nih.gov/mesh/D002633 http://id.nlm.nih.gov/mesh/D005260 http://id.nlm.nih.gov/mesh/D007700 http://id.nlm.nih.gov/mesh/D008810 http://id.nlm.nih.gov/mesh/D011374 http://id.nlm.nih.gov/mesh/D013081 http://id.nlm.nih.gov/mesh/D013094 |
| title_short |
Progesterone effects on mouse sperm kinetics in conditions of viscosity |
| title_full |
Progesterone effects on mouse sperm kinetics in conditions of viscosity |
| title_fullStr |
Progesterone effects on mouse sperm kinetics in conditions of viscosity |
| title_full_unstemmed |
Progesterone effects on mouse sperm kinetics in conditions of viscosity |
| title_sort |
Progesterone effects on mouse sperm kinetics in conditions of viscosity |
| dc.creator.fl_str_mv |
López Cardona, Angela Patricia Pérez Cerezales, Serafín Gutiérrez Adán, Alfonso |
| dc.contributor.author.none.fl_str_mv |
López Cardona, Angela Patricia Pérez Cerezales, Serafín Gutiérrez Adán, Alfonso |
| dc.contributor.researchgroup.spa.fl_str_mv |
Biogénesis |
| dc.subject.decs.none.fl_str_mv |
Reacción Acrosómica Acrosome Reaction Factores Quimiotácticos - farmacología Chemotactic Factors - pharmacology Quimiotaxis - efectos de los fármacos Chemotaxis - drug effects Cinética Kinetics Espermatozoides - efectos de los fármacos Spermatozoa - drug effects Motilidad Espermática - efectos de los fármacos Sperm Motility - drug effects Ratones Endogámicos C57BL Mice, Inbred C57BL Progesterona Progesterone |
| topic |
Reacción Acrosómica Acrosome Reaction Factores Quimiotácticos - farmacología Chemotactic Factors - pharmacology Quimiotaxis - efectos de los fármacos Chemotaxis - drug effects Cinética Kinetics Espermatozoides - efectos de los fármacos Spermatozoa - drug effects Motilidad Espermática - efectos de los fármacos Sperm Motility - drug effects Ratones Endogámicos C57BL Mice, Inbred C57BL Progesterona Progesterone http://id.nlm.nih.gov/mesh/D020101 http://id.nlm.nih.gov/mesh/D000818 http://id.nlm.nih.gov/mesh/D002630 http://id.nlm.nih.gov/mesh/D002633 http://id.nlm.nih.gov/mesh/D005260 http://id.nlm.nih.gov/mesh/D007700 http://id.nlm.nih.gov/mesh/D008810 http://id.nlm.nih.gov/mesh/D011374 http://id.nlm.nih.gov/mesh/D013081 http://id.nlm.nih.gov/mesh/D013094 |
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| description |
ABSTRACT: The spermatozoa delivered to the female genital tract need to swim towards the oocyte through viscous secretions. Once close to the oocyte, the spermatozoa are guided by a gradient of progesterone (P4) and other unknown chemoattractants via a process known as chemotaxis. Using polyvinylpyrrolidone to establish the conditions of viscosity, we examined the response of mouse spermatozoa to P4. Herein, we show that in low-viscous media, P4 induces hyperactive-like motility whereby sperm show erratic trajectories and non-progressive movement. However, an opposite response is produced in viscous medium in that trajectories are linear and motility is more progressive and less erratic. Our observations provide a behavioural explanation for the chemotaxis of spermatozoa swimming under viscous conditions in a spatial gradient of the chemoattractant P4. They also highlight the importance of using viscous solutions to mimic in vivo conditions when analysing sperm behaviour in response to any stimulus. |
| publishDate |
2016 |
| dc.date.issued.none.fl_str_mv |
2016 |
| dc.date.accessioned.none.fl_str_mv |
2023-12-06T22:42:40Z |
| dc.date.available.none.fl_str_mv |
2023-12-06T22:42:40Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Pérez-Cerezales, S., López-Cardona, A. P., & Gutiérrez-Adán, A. (2016). Progesterone effects on mouse sperm kinetics in conditions of viscosity. Reproduction, 151(5), 501-507. Retrieved Dec 5, 2023, from https://doi.org/10.1530/REP-15-0582 |
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1470-1626 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/37520 |
| dc.identifier.doi.none.fl_str_mv |
10.1530/REP-15-0582 |
| dc.identifier.eissn.none.fl_str_mv |
1741-7899 |
| identifier_str_mv |
Pérez-Cerezales, S., López-Cardona, A. P., & Gutiérrez-Adán, A. (2016). Progesterone effects on mouse sperm kinetics in conditions of viscosity. Reproduction, 151(5), 501-507. Retrieved Dec 5, 2023, from https://doi.org/10.1530/REP-15-0582 1470-1626 10.1530/REP-15-0582 1741-7899 |
| url |
https://hdl.handle.net/10495/37520 |
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eng |
| language |
eng |
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Reproduction |
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507 |
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501 |
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151 |
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Reproduction |
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Society for Reproduction and Fertility |
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Bristol, Inglaterra |
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López Cardona, Angela PatriciaPérez Cerezales, SerafínGutiérrez Adán, AlfonsoBiogénesis2023-12-06T22:42:40Z2023-12-06T22:42:40Z2016Pérez-Cerezales, S., López-Cardona, A. P., & Gutiérrez-Adán, A. (2016). Progesterone effects on mouse sperm kinetics in conditions of viscosity. Reproduction, 151(5), 501-507. Retrieved Dec 5, 2023, from https://doi.org/10.1530/REP-15-05821470-1626https://hdl.handle.net/10495/3752010.1530/REP-15-05821741-7899ABSTRACT: The spermatozoa delivered to the female genital tract need to swim towards the oocyte through viscous secretions. Once close to the oocyte, the spermatozoa are guided by a gradient of progesterone (P4) and other unknown chemoattractants via a process known as chemotaxis. Using polyvinylpyrrolidone to establish the conditions of viscosity, we examined the response of mouse spermatozoa to P4. Herein, we show that in low-viscous media, P4 induces hyperactive-like motility whereby sperm show erratic trajectories and non-progressive movement. However, an opposite response is produced in viscous medium in that trajectories are linear and motility is more progressive and less erratic. Our observations provide a behavioural explanation for the chemotaxis of spermatozoa swimming under viscous conditions in a spatial gradient of the chemoattractant P4. They also highlight the importance of using viscous solutions to mimic in vivo conditions when analysing sperm behaviour in response to any stimulus.Colombia. Ministerio de Ciencia, Tecnología e InnovaciónMinisterio de Economía, Comercio y EmpresaCOL00665617application/pdfengSociety for Reproduction and FertilityBristol, Inglaterrahttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Progesterone effects on mouse sperm kinetics in conditions of viscosityArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionReacción AcrosómicaAcrosome ReactionFactores Quimiotácticos - farmacologíaChemotactic Factors - pharmacologyQuimiotaxis - efectos de los fármacosChemotaxis - drug effectsCinéticaKineticsEspermatozoides - efectos de los fármacosSpermatozoa - drug effectsMotilidad Espermática - efectos de los fármacosSperm Motility - drug effectsRatones Endogámicos C57BLMice, Inbred C57BLProgesteronaProgesteronehttp://id.nlm.nih.gov/mesh/D020101http://id.nlm.nih.gov/mesh/D000818http://id.nlm.nih.gov/mesh/D002630http://id.nlm.nih.gov/mesh/D002633http://id.nlm.nih.gov/mesh/D005260http://id.nlm.nih.gov/mesh/D007700http://id.nlm.nih.gov/mesh/D008810http://id.nlm.nih.gov/mesh/D011374http://id.nlm.nih.gov/mesh/D013081http://id.nlm.nih.gov/mesh/D013094Reproduction5075501151ReproductionAGL2012-39652-C02-01512/2010RoR:03fd5ne08PublicationCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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