Pentacyclic Triterpene Profile and Its Biosynthetic Pathway in Cecropia telenitida as a Prospective Dietary Supplement

ABSTRACT: Promising research over the past decades has shown that some types of pentacyclic triterpenes (PTs) are associated with the prevention of type 2 diabetes (T2D), especially those found in foods. The most abundant edible sources of PTs are those belonging to the ursane and oleanane scaffold. The principal finding is that Cecropia telenitida contains abundant oleanane and ursane PT types with similar oxygenation patterns to those found in food matrices. We studied the compositional profile of a rich PT fraction (DE16-R) and carried out a viability test over different cell lines. The biosynthetic pathway connected to the isolated PTs in C. telenitida offers a specific medicinal benefit related to the modulation of T2D. This current study suggests that this plant can assemble isobaric, positional isomers or epimeric PT. Ursane or oleanane scaffolds with the same oxygenation pattern are always shared by the PTs in C. telenitida, as demonstrated by its biosynthetic pathway. Local communities have long used this plant in traditional medicine, and humans have consumed ursane and oleanane PTs in fruits since ancient times, two key points we believe useful in considering the medicinal benefits of C. telenitida and explaining how a group of molecules sharing a closely related scaffold can express effectiveness.

• Autores: Galeano Jaramillo, Elkin de Jesús; Balcázar Morales, Norman; Gutiérrez Gómez, Gustavo Adolfo; Valencia, Laura Marcela; Giraldo Dávila, Deisy; Combariza, Marianny Y.; Panay, Aram J.; Jerez, Alejandra María; Montoya, Guillermo
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2021
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/38984
• Acceso en línea: https://hdl.handle.net/10495/38984
• Palabra clave: Vías Biosintéticas; Biosynthetic Pathways; Cecropia - química; Cecropia Plant - chemistry; Muerte Celular - efectos de los fármacos; Cell Death - drug effects; Línea Celular; Cell Line; Supervivencia Celular - efectos de los fármacos; Cell Survival - drug effects; Fraccionamiento Químico; Chemical Fractionation; Cromatografía Líquida de Alta Presión; Chromatography, High Pressure Liquid; Suplementos Dietéticos; Dietary Supplements; Espectroscopía de Resonancia Magnética; Magnetic Resonance Spectroscopy; Ratones; Mice; Triterpenos Pentacíclicos; Pentacyclic Triterpenes; https://id.nlm.nih.gov/mesh/D053898; https://id.nlm.nih.gov/mesh/D035702; https://id.nlm.nih.gov/mesh/D016923; https://id.nlm.nih.gov/mesh/D002460; https://id.nlm.nih.gov/mesh/D002470; https://id.nlm.nih.gov/mesh/D005591; https://id.nlm.nih.gov/mesh/D002851; https://id.nlm.nih.gov/mesh/D019587; https://id.nlm.nih.gov/mesh/D009682; https://id.nlm.nih.gov/mesh/D051379; https://id.nlm.nih.gov/mesh/D053978
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/