Enzymatic polymorphis and phylogenetic relationships in Leishmania Ross, 1903 (Sarcomastigophora: Kinetoplastida): a case study in Colombia

Leishmaniasis is widespread in Colombia and is found in 30 of 32 Departments. More than 200 infection zones have been reported from different regions, which vary from sea-level to an altitude of 2,300 m along the Atlantic Coast, Pacific coast, Amazon basin, Cauca and Magdalena valleys. We report 76 Leishmania stocks isolated from humans, dogs and phlebotomine hosts. Isoenzyme electrophoresis revealed 16 zymodemes, which could be divided into four phylogenetic complexes, i.e., L. braziliensis, L. amazonensis, L. guyanensis/panamensis and L. infantum. Three zymodemes became integrated into the subgenus Leishmania and the other zymodemes into the subgenus Viannia. Cutaneous infections were due to the L. braziliensis (9.2%) and L. guyanensis/panamensis (85.54%) complexes. Mucous secondary involvement was due to the L. braziliensis and L. guyanensis/panamensis complexes. In this work the specific status of L. (V.) guyanensis and L. (V.) panamensis is discussed.

• Autores: Vélez Bernal, Iván Darío; Agudelo López, Sonia del Pilar; Thomaz Soccol, Vannette; Pratlong, Francini; Lanotte, Genoveve; Rioux, Jean Antoine
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2000
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/47249
• Acceso en línea: https://hdl.handle.net/10495/47249
• Palabra clave: Enfermedades de los Perros - parasitología; Dog Diseases - parasitology; Electroforesis en Gel de Almidón; Electrophoresis, Starch Gel; Focalización Isoeléctrica; Isoelectric Focusing; Isoenzimas - análisis; Isoenzymes - analysis; Leishmania; Leishmaniasis; Filogenia; Phylogeny; Polimorfismo Genético; Polymorphism, Genetic; Psychodidae; https://id.nlm.nih.gov/mesh/D004283; https://id.nlm.nih.gov/mesh/D004592; https://id.nlm.nih.gov/mesh/D007525; https://id.nlm.nih.gov/mesh/D007527; https://id.nlm.nih.gov/mesh/D007891; https://id.nlm.nih.gov/mesh/D007896; https://id.nlm.nih.gov/mesh/D010802; https://id.nlm.nih.gov/mesh/D011110; https://id.nlm.nih.gov/mesh/D011576; ODS 3: Salud y bienestar. Garantizar una vida sana y promover el bienestar de todos a todas las edades
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-nd/4.0/