Therapeutic equivalence requires pharmaceutical, pharmacokinetic and pharmacodynamic identity: true bioequivalence of a generic product of intravenous metronidazole

ABSTRACT: Animal models of infection have been used to demonstrate the therapeutic failure of "bioequivalent" generic products, but their applicability for this purpose requires the accurate identification of those products that are truly bioequivalent. Here, we present data comparing one...

Full description

Autores:

Agudelo Pérez, María
Vesga Meneses, Omar

Tipo de recurso:

Article of investigation

Fecha de publicación:

2012

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/44333

Acceso en línea:

https://hdl.handle.net/10495/44333

Palabra clave:

Antibacterianos
Anti-Bacterial Agents
Área Bajo la Curva
Area Under Curve
Infecciones por Bacteroides
Bacteroides Infections
Bacteroides fragilis
Cromatografía Liquida
Chromatography, Liquid
Medicamentos Genéricos
Drugs, Generic
Inyecciones Intravenosas
Injections, Intravenous
Metronidazol
Metronidazole
Pruebas de Sensibilidad Microbiana
Microbial Sensitivity Tests
Neutropenia
Infecciones Estafilocócicas
Staphylococcal Infections
Staphylococcus aureus
Equivalencia Terapéutica
Therapeutic Equivalency
Muslo
Thigh
https://id.nlm.nih.gov/mesh/D000900
https://id.nlm.nih.gov/mesh/D019540
https://id.nlm.nih.gov/mesh/D001442
https://id.nlm.nih.gov/mesh/D001441
https://id.nlm.nih.gov/mesh/D002853
https://id.nlm.nih.gov/mesh/D016568
https://id.nlm.nih.gov/mesh/D007275
https://id.nlm.nih.gov/mesh/D008795
https://id.nlm.nih.gov/mesh/D008826
https://id.nlm.nih.gov/mesh/D009503
https://id.nlm.nih.gov/mesh/D013203
https://id.nlm.nih.gov/mesh/D013211
https://id.nlm.nih.gov/mesh/D013810
https://id.nlm.nih.gov/mesh/D013848

Rights

openAccess

License

https://creativecommons.org/licenses/by/4.0/