Inhibitory effects of varespladib, CP471474, and their potential synergistic activity on bothrops asper and crotalus durissus cumanensis venoms

ABSTRACT: Snakebite is a neglected tropical disease that causes extensive mortality and morbidity in rural communities. Antivenim sera are the currently approved therapy for snake bites; however, they have some therapeutic limitations that have been extensively documented. Recently, small molecule t...

Full description

Autores:

Granados Vega, Elkyn Johan
Quiroz Suárez, Sara Cristina
Henao Castañeda, Isabel Cristina
Patiño Llano, Arley Camilo
Preciado Rojo, Lina María
Pereañez Jiménez, Jaime Andrés

Tipo de recurso:

Article of investigation

Fecha de publicación:

2022

Institución:

Universidad de Antioquia

Repositorio:

Repositorio UdeA

Idioma:

eng

OAI Identifier:

oai:bibliotecadigital.udea.edu.co:10495/40553

Acceso en línea:

https://hdl.handle.net/10495/40553

Palabra clave:

Antivenenos - farmacología
Antivenins - pharmacology
Antivenenos - uso terapéutico
Antivenins - therapeutic use
Bothrops
Venenos de Crotálidos - toxicidad
Crotalid Venoms - toxicity
Edema - inducido químicamente
Edema - chemically induced
Edema - tratamiento farmacológico
Edema - drug therapy
Hemorragia - tratamiento farmacológico
Hemorrhage - drug therapy
Metaloproteasas
Metalloproteases
Simulación del Acoplamiento Molecular
Molecular Docking Simulation
Mordeduras de Serpientes - tratamiento farmacológico
Snake Bites - drug therapy
https://id.nlm.nih.gov/mesh/D000997
https://id.nlm.nih.gov/mesh/D017837
https://id.nlm.nih.gov/mesh/D003435
https://id.nlm.nih.gov/mesh/D004487
https://id.nlm.nih.gov/mesh/D006470
https://id.nlm.nih.gov/mesh/D045726
https://id.nlm.nih.gov/mesh/D062105
https://id.nlm.nih.gov/mesh/D012909

Rights

openAccess

License

http://creativecommons.org/licenses/by/2.5/co/