Histoplasma capsulatum modulates the immune response exerted by mesenchymal stromal cells

ABSTRACT: Mesenchymal stromal cells (MSCs) have become a tool not only for tissue regeneration but also for the treatment of inflammatory diseases. Several studies have demonstrated the therapeutic potential of MSCs for the treatment of noninfectious inflammatory diseases; however, they appear to play a dual role in infectious diseases. Histoplasmosis is a systemic mycosis caused by Histoplasma spp., which occurs mainly in immunosuppressed individuals; this mycosis can present a severe clinical picture with dissemination to various organs, and is associated with an exacerbated inflammatory response and with anemia and pancytopenia if bone marrow is affected. So far, the effect of a possible interaction of Histoplasma with stem cells present in the bone marrow is unknown.

• Autores: Rodríguez Echeverri, Carolina; González Marín, Ángel Augusto; Gómez Giraldo, Beatriz Lucía
• Tipo de recurso: http://purl.org/coar/resource_type/c_6670
• Fecha de publicación: 2022
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/33582
• Acceso en línea: https://hdl.handle.net/10495/33582
• Palabra clave: Apoptosis; Diferenciación Celular; Cell Differentiation; Proliferación Celular; Cell Proliferation; Histoplasma; Células Madre Mesenquimatosas - metabolismo; Mesenchymal Stem Cells - metabolism; Inmunidad; Immunity
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-sa/4.0/