Colistin resistance in carbapenem resistant klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA

ABSTRACT : Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB. Nineteen isolates belonged to sequence type 512 (ST512) (o...

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Autores:
Cienfuegos Gallet, Astrid Vanessa
Chen, Liang
Kreiswirth, Barry
Jimenes Quiceno, Judy Natalia
Tipo de recurso:
Article of investigation
Fecha de publicación:
2017
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/20639
Acceso en línea:
http://hdl.handle.net/10495/20639
Palabra clave:
Klebsiella pneumoniae
Colistina
Colistin
Enterobacteriaceae Resistentes a los Carbapenémicos
Carbapenem-Resistant Enterobacteriaceae
Rights
openAccess
License
https://creativecommons.org/licenses/by/4.0/
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dc.title.spa.fl_str_mv Colistin resistance in carbapenem resistant klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA
title Colistin resistance in carbapenem resistant klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA
spellingShingle Colistin resistance in carbapenem resistant klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA
Klebsiella pneumoniae
Colistina
Colistin
Enterobacteriaceae Resistentes a los Carbapenémicos
Carbapenem-Resistant Enterobacteriaceae
title_short Colistin resistance in carbapenem resistant klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA
title_full Colistin resistance in carbapenem resistant klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA
title_fullStr Colistin resistance in carbapenem resistant klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA
title_full_unstemmed Colistin resistance in carbapenem resistant klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA
title_sort Colistin resistance in carbapenem resistant klebsiella pneumoniae mediated by chromosomal integration of plasmid DNA
dc.creator.fl_str_mv Cienfuegos Gallet, Astrid Vanessa
Chen, Liang
Kreiswirth, Barry
Jimenes Quiceno, Judy Natalia
dc.contributor.author.none.fl_str_mv Cienfuegos Gallet, Astrid Vanessa
Chen, Liang
Kreiswirth, Barry
Jimenes Quiceno, Judy Natalia
dc.contributor.researchgroup.spa.fl_str_mv Grupo de Investigación en Microbiología Básica y Aplicada-Microba
dc.subject.decs.none.fl_str_mv Klebsiella pneumoniae
Colistina
Colistin
Enterobacteriaceae Resistentes a los Carbapenémicos
Carbapenem-Resistant Enterobacteriaceae
topic Klebsiella pneumoniae
Colistina
Colistin
Enterobacteriaceae Resistentes a los Carbapenémicos
Carbapenem-Resistant Enterobacteriaceae
description ABSTRACT : Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB. Nineteen isolates belonged to sequence type 512 (ST512) (or its single locus variant [SLV]) and harbored an 8.1-kb hsdMSR insertion corresponding to ISKpn25, indicating a clonal expansion of the resistant strain. The insertion region showed 100% identity to several plasmids, suggesting that the colistin resistance is mediated by chromosomal integration of plasmid DNA.
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2021-07-04T14:00:51Z
dc.date.available.none.fl_str_mv 2021-07-04T14:00:51Z
dc.type.spa.fl_str_mv Artículo de investigación
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dc.identifier.doi.none.fl_str_mv 10.1128/AAC.00404-17
dc.identifier.eissn.none.fl_str_mv 1098-6596
identifier_str_mv 0066-4804
10.1128/AAC.00404-17
1098-6596
url http://hdl.handle.net/10495/20639
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Antimicrob. agents chemother
dc.relation.citationendpage.spa.fl_str_mv 5
dc.relation.citationissue.spa.fl_str_mv 8
dc.relation.citationstartpage.spa.fl_str_mv 1
dc.relation.citationvolume.spa.fl_str_mv 61
dc.relation.ispartofjournal.spa.fl_str_mv Antimicrobial Agents and Chemotherapy
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dc.publisher.spa.fl_str_mv American Society for Microbiology
dc.publisher.place.spa.fl_str_mv Washington, Estados Unidos
institution Universidad de Antioquia
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spelling Cienfuegos Gallet, Astrid VanessaChen, LiangKreiswirth, BarryJimenes Quiceno, Judy NataliaGrupo de Investigación en Microbiología Básica y Aplicada-Microba2021-07-04T14:00:51Z2021-07-04T14:00:51Z20170066-4804http://hdl.handle.net/10495/2063910.1128/AAC.00404-171098-6596ABSTRACT : Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB. Nineteen isolates belonged to sequence type 512 (ST512) (or its single locus variant [SLV]) and harbored an 8.1-kb hsdMSR insertion corresponding to ISKpn25, indicating a clonal expansion of the resistant strain. 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