Spontaneous Control of HIV Replication, but not HAART-Induced Viral Suppression, Is Associated With Lower Activation of Immune Cell

ABSTRACT: HIV replication control is important to reduce AIDS progression. We determined frequency and activation status of immune cells in spontaneous HIV controllers vs. individuals with highly active antiretroviral therapy (HAART)-controlled viral load. HIV controllers exhibited significantly higher frequency of CD4+ T cells and myeloid dendritic cells compared with HAART-controlled viral load. Addition ally, HIV controllers have a significantly lower percentage of cells expressing activation markers on CD4+ and CD8+ T cells, myeloid dendritic cells, and natural killer cells. These findings suggest that during HIV infection, conservation of a normal frequency and physi ological range of immune activation is associated with spontaneous, but not HAART-induced, control of viral replication.

• Autores: Taborda Vanegas, Natalia Andrea; Correa Londoño, Luis Alfonso; Feria Garzón, Manuel Gerónimo; Rugeles López, María Teresa
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2014
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/37245
• Acceso en línea: https://hdl.handle.net/10495/37245
• Palabra clave: HIV; HIV; Antígenos CD8; CD8 Antigens; Antígenos CD4; CD4 Antigens; Replicación Viral; Virus Replication; VIH no-Progresivos; HIV Non-Progressors; Terapia Antirretroviral Altamente Activa; Antiretroviral Therapy, Highly Active; Regulación de la Expresión Génica; Gene Expression Regulation; Activación de Linfocitos; Lymphocyte Activation; Carga Viral; Viral Load
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-nd/4.0/