Functional genomics of HMGN3a and SMARCAL1 in early mammalian embryogenesis

ABSTRACT: Background: Embryonic genome activation (EGA) is a critical event for the preimplantation embryo, which is manifested by changes in chromatin structure, transcriptional machinery, expression of embryonic genes, and degradation of maternal transcripts. The objectives of this study were to determine transcript abundance of HMGN3a and SMARCAL1 in mature bovine oocytes and early bovine embryos, to perform comparative functional genomics analysis of these genes across mammals.

• Autores: Rodríguez Osorio, Nélida; Uzun, Alper; Kaya, Abdullah; Wang, Hongfeng; Parrish, John J.; Ilyin, Valentin A.; Memili, Erdogan
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2009
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/33392
• Acceso en línea: https://hdl.handle.net/10495/33392
• Palabra clave: Genómica; Genomics; Blastocisto; Blastocyst; Bovinos; Cattle; Secuencia de Aminoácidos; Amino Acid Sequence; Desarrollo Embrionario; Embryonic Development; Ensamble y Desensamble de Cromatina; Chromatin Assembly and Disassembly; Regulación del Desarrollo de la Expresión Génica; Gene Expression Regulation, Developmental; Oocitos; Oocytes; Filogenia; Phylogeny; Modelos Moleculares; Models, Molecular; Proteínas HMGN; HMGN Proteins; ADN Helicasas; DNA Helicases
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/