Polymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus
ABSTRACT: Triterpene-enriched fractions (TFs) from Eucalyptus tereticornis demonstrated efficiency when administered intraperitoneally in diet-induced obesity (DIO) mouse model to treat obesity-related type 2 diabetes mellitus (T2DM); however, its oral administration has not yet led to satisfactory...
- Autores:
-
Escobar Chaves, Elkin Leandro
Acín Martínez, Sergio
Muñoz Herrera, Diana Lorena
Fernández Culma, Maritza
Echeverri, Alexandra
Echeverri López, Luis Fernando
Orozco Holguín, Jahir
Balcázar Morales, Norman
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2023
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/33500
- Acceso en línea:
- https://hdl.handle.net/10495/33500
- Palabra clave:
- Polímeros
Polymers
Obesidad
Obesity
Inflamación
Inflammation
Triterpenos
Triterpenes
Ratones
Mice
Diabetes Mellitus Tipo 2
Diabetes Mellitus, Type 2
Eucalyptus tereticornis
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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Polymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| title |
Polymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| spellingShingle |
Polymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus Polímeros Polymers Obesidad Obesity Inflamación Inflammation Triterpenos Triterpenes Ratones Mice Diabetes Mellitus Tipo 2 Diabetes Mellitus, Type 2 Eucalyptus tereticornis |
| title_short |
Polymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| title_full |
Polymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| title_fullStr |
Polymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| title_full_unstemmed |
Polymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| title_sort |
Polymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| dc.creator.fl_str_mv |
Escobar Chaves, Elkin Leandro Acín Martínez, Sergio Muñoz Herrera, Diana Lorena Fernández Culma, Maritza Echeverri, Alexandra Echeverri López, Luis Fernando Orozco Holguín, Jahir Balcázar Morales, Norman |
| dc.contributor.author.none.fl_str_mv |
Escobar Chaves, Elkin Leandro Acín Martínez, Sergio Muñoz Herrera, Diana Lorena Fernández Culma, Maritza Echeverri, Alexandra Echeverri López, Luis Fernando Orozco Holguín, Jahir Balcázar Morales, Norman |
| dc.contributor.researchgroup.spa.fl_str_mv |
Genética Molecular (GENMOL) Química Orgánica de Productos Naturales |
| dc.subject.decs.none.fl_str_mv |
Polímeros Polymers Obesidad Obesity Inflamación Inflammation Triterpenos Triterpenes Ratones Mice Diabetes Mellitus Tipo 2 Diabetes Mellitus, Type 2 |
| topic |
Polímeros Polymers Obesidad Obesity Inflamación Inflammation Triterpenos Triterpenes Ratones Mice Diabetes Mellitus Tipo 2 Diabetes Mellitus, Type 2 Eucalyptus tereticornis |
| dc.subject.proposal.spa.fl_str_mv |
Eucalyptus tereticornis |
| description |
ABSTRACT: Triterpene-enriched fractions (TFs) from Eucalyptus tereticornis demonstrated efficiency when administered intraperitoneally in diet-induced obesity (DIO) mouse model to treat obesity-related type 2 diabetes mellitus (T2DM); however, its oral administration has not yet led to satisfactory results. In this context, we developed a polymeric nanoformulation to transport TFs orally in DIO mice and control obesity and T2DM effects. We encapsulated TFs in a polylactic-co-glycolic acid-based nanocarrier, physicochemically characterized the nanocarriers, and evaluated TFs in-vitro release kinetics, in-vivo metabolic biomarkers, and released triterpenes in a simulated in-vitro human gastrointestinal model. The nanoformulation showed a TFs release of 80% in the first 6h in-vitro, and the in-vivo assay demonstrated a decrease in mice weight, glycaemia, glucose, and insulin intolerance. Finally, triterpenes released up to 75% in the simulated in-vitro human intestine. These results open the way for developing new strategies of therapeutic agents with natural products to control obesity and T2DM. |
| publishDate |
2023 |
| dc.date.accessioned.none.fl_str_mv |
2023-02-16T14:42:36Z |
| dc.date.available.none.fl_str_mv |
2023-02-16T14:42:36Z |
| dc.date.issued.none.fl_str_mv |
2023 |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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https://purl.org/redcol/resource_type/ART |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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publishedVersion |
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1773-2247 |
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https://hdl.handle.net/10495/33500 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.jddst.2023.104264 |
| dc.identifier.eissn.none.fl_str_mv |
2588-8943 |
| identifier_str_mv |
1773-2247 10.1016/j.jddst.2023.104264 2588-8943 |
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https://hdl.handle.net/10495/33500 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
J. Drug Deliv. Sci. Technol. |
| dc.relation.citationendpage.spa.fl_str_mv |
11 |
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1 |
| dc.relation.citationvolume.spa.fl_str_mv |
81 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Journal of Drug Delivery Science and Technology |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/2.5/co/ |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Atribución-NoComercial-SinDerivadas 2.5 Colombia |
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application/pdf |
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Elsevier |
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París, Francia |
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Escobar Chaves, Elkin LeandroAcín Martínez, SergioMuñoz Herrera, Diana LorenaFernández Culma, MaritzaEcheverri, AlexandraEcheverri López, Luis FernandoOrozco Holguín, JahirBalcázar Morales, NormanGenética Molecular (GENMOL)Química Orgánica de Productos Naturales2023-02-16T14:42:36Z2023-02-16T14:42:36Z20231773-2247https://hdl.handle.net/10495/3350010.1016/j.jddst.2023.1042642588-8943ABSTRACT: Triterpene-enriched fractions (TFs) from Eucalyptus tereticornis demonstrated efficiency when administered intraperitoneally in diet-induced obesity (DIO) mouse model to treat obesity-related type 2 diabetes mellitus (T2DM); however, its oral administration has not yet led to satisfactory results. In this context, we developed a polymeric nanoformulation to transport TFs orally in DIO mice and control obesity and T2DM effects. We encapsulated TFs in a polylactic-co-glycolic acid-based nanocarrier, physicochemically characterized the nanocarriers, and evaluated TFs in-vitro release kinetics, in-vivo metabolic biomarkers, and released triterpenes in a simulated in-vitro human gastrointestinal model. The nanoformulation showed a TFs release of 80% in the first 6h in-vitro, and the in-vivo assay demonstrated a decrease in mice weight, glycaemia, glucose, and insulin intolerance. Finally, triterpenes released up to 75% in the simulated in-vitro human intestine. These results open the way for developing new strategies of therapeutic agents with natural products to control obesity and T2DM.COL0006723COL001533911application/pdfengElsevierParís, Franciahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/https://creativecommons.org/licenses/by-nc-nd/4.0/Atribución-NoComercial-SinDerivadas 2.5 Colombiainfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Polymeric nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitusArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPolímerosPolymersObesidadObesityInflamaciónInflammationTriterpenosTriterpenesRatonesMiceDiabetes Mellitus Tipo 2Diabetes Mellitus, Type 2Eucalyptus tereticornisJ. Drug Deliv. Sci. 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