The triterpene hederagenin glucoside saponins and chromane hydrazone 2-(2,3-dihydro-4h-1- benzopyran-4-ylidene) hydrazide as active ingredients of topical formulation to treat cutaneous leishmaniasis
ABSTRACT: Cutaneous leishmaniasis (CL) is an endemic infection worldwide. Due to variable response to therapy and frequency of relapses, a more effective, safe, and inexpensive treatment is needed. Previously it was reported that the hederagenin glucoside saponins (SS) and chromane hydrazone (TC2) c...
- Autores:
-
Piragauta, Sandra
Higuita Castro, Jorge Luis
Arbeláez Córdoba, Natalia
Restrepo Agudelo, Adriana María
Archbold Joseph, Rosendo
Quiñones Fletcher, Wiston
Torres, Fernando
Echeverri López, Luis Fernando
Escobar Peláez, Gustavo
Vélez Bernal, Iván Darío
Montoya Cuervo, Edwin Andrés
Robledo Restrepo, Sara María
- Tipo de recurso:
- http://purl.org/coar/resource_type/c_6670
- Fecha de publicación:
- 2022
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/34759
- Acceso en línea:
- https://hdl.handle.net/10495/34759
- Palabra clave:
- Leishmaniasis Cutánea
Leishmaniasis, Cutaneous
Triterpenos
Triterpenes
Enfermedades Parasitarias
Parasitic Diseases
Saponinas
Saponins
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-sa/2.5/co/
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| dc.title.spa.fl_str_mv |
The triterpene hederagenin glucoside saponins and chromane hydrazone 2-(2,3-dihydro-4h-1- benzopyran-4-ylidene) hydrazide as active ingredients of topical formulation to treat cutaneous leishmaniasis |
| title |
The triterpene hederagenin glucoside saponins and chromane hydrazone 2-(2,3-dihydro-4h-1- benzopyran-4-ylidene) hydrazide as active ingredients of topical formulation to treat cutaneous leishmaniasis |
| spellingShingle |
The triterpene hederagenin glucoside saponins and chromane hydrazone 2-(2,3-dihydro-4h-1- benzopyran-4-ylidene) hydrazide as active ingredients of topical formulation to treat cutaneous leishmaniasis Leishmaniasis Cutánea Leishmaniasis, Cutaneous Triterpenos Triterpenes Enfermedades Parasitarias Parasitic Diseases Saponinas Saponins |
| title_short |
The triterpene hederagenin glucoside saponins and chromane hydrazone 2-(2,3-dihydro-4h-1- benzopyran-4-ylidene) hydrazide as active ingredients of topical formulation to treat cutaneous leishmaniasis |
| title_full |
The triterpene hederagenin glucoside saponins and chromane hydrazone 2-(2,3-dihydro-4h-1- benzopyran-4-ylidene) hydrazide as active ingredients of topical formulation to treat cutaneous leishmaniasis |
| title_fullStr |
The triterpene hederagenin glucoside saponins and chromane hydrazone 2-(2,3-dihydro-4h-1- benzopyran-4-ylidene) hydrazide as active ingredients of topical formulation to treat cutaneous leishmaniasis |
| title_full_unstemmed |
The triterpene hederagenin glucoside saponins and chromane hydrazone 2-(2,3-dihydro-4h-1- benzopyran-4-ylidene) hydrazide as active ingredients of topical formulation to treat cutaneous leishmaniasis |
| title_sort |
The triterpene hederagenin glucoside saponins and chromane hydrazone 2-(2,3-dihydro-4h-1- benzopyran-4-ylidene) hydrazide as active ingredients of topical formulation to treat cutaneous leishmaniasis |
| dc.creator.fl_str_mv |
Piragauta, Sandra Higuita Castro, Jorge Luis Arbeláez Córdoba, Natalia Restrepo Agudelo, Adriana María Archbold Joseph, Rosendo Quiñones Fletcher, Wiston Torres, Fernando Echeverri López, Luis Fernando Escobar Peláez, Gustavo Vélez Bernal, Iván Darío Montoya Cuervo, Edwin Andrés Robledo Restrepo, Sara María |
| dc.contributor.author.none.fl_str_mv |
Piragauta, Sandra Higuita Castro, Jorge Luis Arbeláez Córdoba, Natalia Restrepo Agudelo, Adriana María Archbold Joseph, Rosendo Quiñones Fletcher, Wiston Torres, Fernando Echeverri López, Luis Fernando Escobar Peláez, Gustavo Vélez Bernal, Iván Darío Montoya Cuervo, Edwin Andrés Robledo Restrepo, Sara María |
| dc.contributor.conferencename.spa.fl_str_mv |
(22 : Tetrahedron Symposium. Catalysis for Sustainable World : 28 de junio al 1 de julio de 2022 : Lisboa, Portugal) |
| dc.contributor.researchgroup.spa.fl_str_mv |
Programa de Estudio y Control de Enfermedades Tropicales (PECET) Química Orgánica de Productos Naturales |
| dc.subject.decs.none.fl_str_mv |
Leishmaniasis Cutánea Leishmaniasis, Cutaneous Triterpenos Triterpenes Enfermedades Parasitarias Parasitic Diseases Saponinas Saponins |
| topic |
Leishmaniasis Cutánea Leishmaniasis, Cutaneous Triterpenos Triterpenes Enfermedades Parasitarias Parasitic Diseases Saponinas Saponins |
| description |
ABSTRACT: Cutaneous leishmaniasis (CL) is an endemic infection worldwide. Due to variable response to therapy and frequency of relapses, a more effective, safe, and inexpensive treatment is needed. Previously it was reported that the hederagenin glucoside saponins (SS) and chromane hydrazone (TC2) combined in a 1:1 ratio has high potential in antileishmanial therapy since both compounds may alter the survival of Leishmania and the ability to infect adjacent macrophage. In this work, we developed an ointment formulation containing 2% TC2 and 2% SS (w/w) and determined the skin permeation and the absorption but also the acute dermal toxicity by in vitro and in vivo assays. |
| publishDate |
2022 |
| dc.date.issued.none.fl_str_mv |
2022-06-28 |
| dc.date.accessioned.none.fl_str_mv |
2023-04-25T20:09:42Z |
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2023-04-25T20:09:42Z |
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Póster de conferencia |
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http://purl.org/coar/resource_type/c_c94f |
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http://purl.org/coar/resource_type/c_6670 |
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https://purl.org/redcol/resource_type/EC |
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http://purl.org/coar/version/c_970fb48d4fbd8a85 |
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https://hdl.handle.net/10495/34759 |
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https://hdl.handle.net/10495/34759 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.conferencedate.spa.fl_str_mv |
2022-06-28/2022-07-01 |
| dc.relation.conferenceplace.spa.fl_str_mv |
Lisboa, Portugal |
| dc.relation.ispartofjournal.spa.fl_str_mv |
22nd Tetrahedron Symposium. Catalysis for Sustainable World |
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http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
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info:eu-repo/semantics/openAccess |
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Atribución-NoComercial-CompartirIgual 2.5 Colombia |
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Piragauta, SandraHiguita Castro, Jorge LuisArbeláez Córdoba, NataliaRestrepo Agudelo, Adriana MaríaArchbold Joseph, RosendoQuiñones Fletcher, WistonTorres, FernandoEcheverri López, Luis FernandoEscobar Peláez, GustavoVélez Bernal, Iván DaríoMontoya Cuervo, Edwin AndrésRobledo Restrepo, Sara María(22 : Tetrahedron Symposium. Catalysis for Sustainable World : 28 de junio al 1 de julio de 2022 : Lisboa, Portugal)Programa de Estudio y Control de Enfermedades Tropicales (PECET)Química Orgánica de Productos Naturales2023-04-25T20:09:42Z2023-04-25T20:09:42Z2022-06-28https://hdl.handle.net/10495/34759ABSTRACT: Cutaneous leishmaniasis (CL) is an endemic infection worldwide. Due to variable response to therapy and frequency of relapses, a more effective, safe, and inexpensive treatment is needed. Previously it was reported that the hederagenin glucoside saponins (SS) and chromane hydrazone (TC2) combined in a 1:1 ratio has high potential in antileishmanial therapy since both compounds may alter the survival of Leishmania and the ability to infect adjacent macrophage. In this work, we developed an ointment formulation containing 2% TC2 and 2% SS (w/w) and determined the skin permeation and the absorption but also the acute dermal toxicity by in vitro and in vivo assays.COL0015099COL0015339application/pdfenghttp://creativecommons.org/licenses/by-nc-sa/2.5/co/https://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2The triterpene hederagenin glucoside saponins and chromane hydrazone 2-(2,3-dihydro-4h-1- benzopyran-4-ylidene) hydrazide as active ingredients of topical formulation to treat cutaneous leishmaniasisPóster de conferenciahttp://purl.org/coar/resource_type/c_6670http://purl.org/coar/resource_type/c_c94fhttps://purl.org/redcol/resource_type/EChttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionLeishmaniasis CutáneaLeishmaniasis, CutaneousTriterpenosTriterpenesEnfermedades ParasitariasParasitic DiseasesSaponinasSaponins2022-06-28/2022-07-01Lisboa, Portugal22nd Tetrahedron Symposium. 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