Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model

ABSTRACT: Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported.

• Autores: Balcázar Morales, Norman; Gutiérrez Gómez, Gustavo Adolfo; Giraldo Dávila, Deisy; Combariza Montanez, Marianny Yajaira; Holzgrabe, Ulrike; Tabares Guevara, Jorge Humberto; Ramírez Pineda, José Robinson; Acín Martínez, Sergio; Muñoz Herrera, Diana Lorena; Montoya Pelaéz, Guillermo León
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2020
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/41107
• Acceso en línea: https://hdl.handle.net/10495/41107
• Palabra clave: Adipose Tissue; Tejido Adiposo; Biomarkers; Biomarcadores; Body Weight; Peso Corporal; Carbohydrate Metabolism; Metabolismo de los Hidratos de Carbono; Diet, High-Fat; Dieta Alta en Grasa; Disease Models, Animal; Modelos Animales de Enfermedad; Gene Expression Regulation; Regulación de la Expresión Génica; Insulin Secretion; Secreción de Insulina; Liver; Hígado; Obesity; Obesidad; Organ Size; Tamaño de los Órganos; Triterpenes; Triterpenos; https://id.nlm.nih.gov/mesh/D000273; https://id.nlm.nih.gov/mesh/D015415; https://id.nlm.nih.gov/mesh/D001835; https://id.nlm.nih.gov/mesh/D050260; https://id.nlm.nih.gov/mesh/D059305; https://id.nlm.nih.gov/mesh/D004195; https://id.nlm.nih.gov/mesh/D005786; https://id.nlm.nih.gov/mesh/D000078790; https://id.nlm.nih.gov/mesh/D008099; https://id.nlm.nih.gov/mesh/D009765; https://id.nlm.nih.gov/mesh/D009929; https://id.nlm.nih.gov/mesh/D014315
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/