Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome
ABSTRACT: In this study were evaluated the effects of the chronic consumption of agraz (Vaccinium meridio-nale) on antioxidant status and oxidative stress markers in 40 women with metabolic syndrome(MetS) (47.2 ± 9.4 years) through a double-blind, crossover design study, in which participants consum...
- Autores:
-
Marín Echeverri, Catalina
Piedrahita Blandón, Manuela
Galvis Pérez, Yeisson Anibal
Núñez Rangel, Vitelbina
Barona Acevedo, María Jacqueline
Blesso, Christopher N.
Fernández, María Luz
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2021
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/41070
- Acceso en línea:
- https://hdl.handle.net/10495/41070
- Palabra clave:
- Estrés Oxidativo
Oxidative Stress
Superóxido Dismutasa
Superoxide Dismutase
Catalasa
Catalase
Glutatión Peroxidasa
Glutathione Peroxidase
Antioxidantes
Antioxidants
Andean berry
Vaccinium meridionale
https://id.nlm.nih.gov/mesh/D018384
https://id.nlm.nih.gov/mesh/D013482
https://id.nlm.nih.gov/mesh/D002374
https://id.nlm.nih.gov/mesh/D005979
https://id.nlm.nih.gov/mesh/D000975
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
| id |
UDEA2_9d10ca185b9eb7998f3cab47ab2101fa |
|---|---|
| oai_identifier_str |
oai:bibliotecadigital.udea.edu.co:10495/41070 |
| network_acronym_str |
UDEA2 |
| network_name_str |
Repositorio UdeA |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome |
| dc.title.translated.spa.fl_str_mv |
Mejoras en el estado antioxidante después del consumo de agraz se asociaron con reducciones en factores de riesgo cardiovascular en mujeres con síndrome metabólico |
| title |
Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome |
| spellingShingle |
Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome Estrés Oxidativo Oxidative Stress Superóxido Dismutasa Superoxide Dismutase Catalasa Catalase Glutatión Peroxidasa Glutathione Peroxidase Antioxidantes Antioxidants Andean berry Vaccinium meridionale https://id.nlm.nih.gov/mesh/D018384 https://id.nlm.nih.gov/mesh/D013482 https://id.nlm.nih.gov/mesh/D002374 https://id.nlm.nih.gov/mesh/D005979 https://id.nlm.nih.gov/mesh/D000975 |
| title_short |
Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome |
| title_full |
Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome |
| title_fullStr |
Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome |
| title_full_unstemmed |
Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome |
| title_sort |
Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome |
| dc.creator.fl_str_mv |
Marín Echeverri, Catalina Piedrahita Blandón, Manuela Galvis Pérez, Yeisson Anibal Núñez Rangel, Vitelbina Barona Acevedo, María Jacqueline Blesso, Christopher N. Fernández, María Luz |
| dc.contributor.author.none.fl_str_mv |
Marín Echeverri, Catalina Piedrahita Blandón, Manuela Galvis Pérez, Yeisson Anibal Núñez Rangel, Vitelbina Barona Acevedo, María Jacqueline Blesso, Christopher N. Fernández, María Luz |
| dc.contributor.researchgroup.spa.fl_str_mv |
Toxinología, Alternativas Terapéuticas y Alimentarias |
| dc.subject.decs.none.fl_str_mv |
Estrés Oxidativo Oxidative Stress Superóxido Dismutasa Superoxide Dismutase Catalasa Catalase Glutatión Peroxidasa Glutathione Peroxidase Antioxidantes Antioxidants |
| topic |
Estrés Oxidativo Oxidative Stress Superóxido Dismutasa Superoxide Dismutase Catalasa Catalase Glutatión Peroxidasa Glutathione Peroxidase Antioxidantes Antioxidants Andean berry Vaccinium meridionale https://id.nlm.nih.gov/mesh/D018384 https://id.nlm.nih.gov/mesh/D013482 https://id.nlm.nih.gov/mesh/D002374 https://id.nlm.nih.gov/mesh/D005979 https://id.nlm.nih.gov/mesh/D000975 |
| dc.subject.proposal.spa.fl_str_mv |
Andean berry Vaccinium meridionale |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D018384 https://id.nlm.nih.gov/mesh/D013482 https://id.nlm.nih.gov/mesh/D002374 https://id.nlm.nih.gov/mesh/D005979 https://id.nlm.nih.gov/mesh/D000975 |
| description |
ABSTRACT: In this study were evaluated the effects of the chronic consumption of agraz (Vaccinium meridio-nale) on antioxidant status and oxidative stress markers in 40 women with metabolic syndrome(MetS) (47.2 ± 9.4 years) through a double-blind, crossover design study, in which participants consumed daily agraz or placebo during 4 weeks, separated by a 4-wk washout period. At the end of each intervention period, endogenous antioxidant enzymes activity, serum total antioxidant capacity (TAC) (ferric reducing ability of plasma [FRAP]; Oxygen Radical Absorbance Capacity[ORAC] and 2,2ʹ-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) [ABTS]), and oxidative stress markers (Oxo-2ʹ-deoxyguanosine (8-OHdG) and F2-isoprostane) were determined. Women who increased endogenous antioxidant enzymes activity and serum TAC after agraz consumption,compared to placebo, significantly reduced oxidative stress markers, total cholesterol, LDL-cho-lesterol (LDL-c) levels, and waist circumference, demonstrating beneficial effects in the group of women in whom antioxidant parameters increased after agraz consumption, evidencing an individual variability in response to the beverage consumed. |
| publishDate |
2021 |
| dc.date.issued.none.fl_str_mv |
2021 |
| dc.date.accessioned.none.fl_str_mv |
2024-08-10T12:47:38Z |
| dc.date.available.none.fl_str_mv |
2024-08-10T12:47:38Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/ART |
| dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
http://purl.org/coar/resource_type/c_2df8fbb1 |
| status_str |
publishedVersion |
| dc.identifier.citation.spa.fl_str_mv |
Marín-Echeverri, C., Piedrahita-Blandón, M., Galvis-Pérez, Y., Blesso, C. N., Fernández, M. L., Nuñez-Rangel, V., & Barona-Acevedo, J. (2021). Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome. CyTA - Journal of Food, 19(1), 238–246. https://doi.org/10.1080/19476337.2021.1884606 |
| dc.identifier.issn.none.fl_str_mv |
1947-6337 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/41070 |
| dc.identifier.doi.none.fl_str_mv |
10.1080/19476337.2021.1884606 |
| dc.identifier.eissn.none.fl_str_mv |
1947-6345 |
| identifier_str_mv |
Marín-Echeverri, C., Piedrahita-Blandón, M., Galvis-Pérez, Y., Blesso, C. N., Fernández, M. L., Nuñez-Rangel, V., & Barona-Acevedo, J. (2021). Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome. CyTA - Journal of Food, 19(1), 238–246. https://doi.org/10.1080/19476337.2021.1884606 1947-6337 10.1080/19476337.2021.1884606 1947-6345 |
| url |
https://hdl.handle.net/10495/41070 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
CYTA. J. Food. |
| dc.relation.citationendpage.spa.fl_str_mv |
246 |
| dc.relation.citationissue.spa.fl_str_mv |
1 |
| dc.relation.citationstartpage.spa.fl_str_mv |
238 |
| dc.relation.citationvolume.spa.fl_str_mv |
19 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
CYTA: Journal of Food |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by/2.5/co/ |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
http://creativecommons.org/licenses/by/2.5/co/ https://creativecommons.org/licenses/by/4.0/ http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.extent.spa.fl_str_mv |
9 páginas |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf - application/epub |
| dc.publisher.spa.fl_str_mv |
Taylor and Francis |
| dc.publisher.place.spa.fl_str_mv |
Abingdon, Inglaterra |
| institution |
Universidad de Antioquia |
| bitstream.url.fl_str_mv |
https://bibliotecadigital.udea.edu.co/bitstreams/def23679-2c08-40d0-975b-fd780da663b1/download https://bibliotecadigital.udea.edu.co/bitstreams/b8ffde79-6c44-41f6-b359-82e70c28a2bc/download https://bibliotecadigital.udea.edu.co/bitstreams/ffc8c103-805a-4d0f-bb7b-443026d6b584/download https://bibliotecadigital.udea.edu.co/bitstreams/3d505b91-256f-46df-9cdd-f460fd17eed8/download https://bibliotecadigital.udea.edu.co/bitstreams/24a92b18-af6a-4151-a134-62385358f6e3/download https://bibliotecadigital.udea.edu.co/bitstreams/485a68dc-8e05-4a19-9395-14070bebaa30/download |
| bitstream.checksum.fl_str_mv |
8bd86884bb20a5dd97d0476eecc52f3c 06bc33fc4ed5a5814b9afd95f6ee09dd 1646d1f6b96dbbbc38035efc9239ac9c 8a4605be74aa9ea9d79846c1fba20a33 423ab10422a57ed3de8d063a1f9735ba 41161ad1150bdb22353849359c830ec4 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional de la Universidad de Antioquia |
| repository.mail.fl_str_mv |
aplicacionbibliotecadigitalbiblioteca@udea.edu.co |
| _version_ |
1851052350804852736 |
| spelling |
Marín Echeverri, CatalinaPiedrahita Blandón, ManuelaGalvis Pérez, Yeisson AnibalNúñez Rangel, VitelbinaBarona Acevedo, María JacquelineBlesso, Christopher N.Fernández, María LuzToxinología, Alternativas Terapéuticas y Alimentarias2024-08-10T12:47:38Z2024-08-10T12:47:38Z2021Marín-Echeverri, C., Piedrahita-Blandón, M., Galvis-Pérez, Y., Blesso, C. N., Fernández, M. L., Nuñez-Rangel, V., & Barona-Acevedo, J. (2021). Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome. CyTA - Journal of Food, 19(1), 238–246. https://doi.org/10.1080/19476337.2021.18846061947-6337https://hdl.handle.net/10495/4107010.1080/19476337.2021.18846061947-6345ABSTRACT: In this study were evaluated the effects of the chronic consumption of agraz (Vaccinium meridio-nale) on antioxidant status and oxidative stress markers in 40 women with metabolic syndrome(MetS) (47.2 ± 9.4 years) through a double-blind, crossover design study, in which participants consumed daily agraz or placebo during 4 weeks, separated by a 4-wk washout period. At the end of each intervention period, endogenous antioxidant enzymes activity, serum total antioxidant capacity (TAC) (ferric reducing ability of plasma [FRAP]; Oxygen Radical Absorbance Capacity[ORAC] and 2,2ʹ-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) [ABTS]), and oxidative stress markers (Oxo-2ʹ-deoxyguanosine (8-OHdG) and F2-isoprostane) were determined. Women who increased endogenous antioxidant enzymes activity and serum TAC after agraz consumption,compared to placebo, significantly reduced oxidative stress markers, total cholesterol, LDL-cho-lesterol (LDL-c) levels, and waist circumference, demonstrating beneficial effects in the group of women in whom antioxidant parameters increased after agraz consumption, evidencing an individual variability in response to the beverage consumed.RESUMEN: En este estudio se evaluaron los efectos del consumo crónico de agraz (Vaccinium meridionale) sobre el estado antioxidante y los marcadores de estrés oxidativo en 40 mujeres con síndrome metabólico(SM) (47,2 ± 9,4 años) mediante un estudio de diseño cruzado, doble ciego, en el que los participantes consumieron diariamente agraz o placebo durante 4 semanas, separados por un período de lavado de 4 semanas. Al final de cada período de intervención se midió la actividad de las enzimas antioxidantes endógenas, la capacidad antioxidante total en suero (capacidad reductora férrica del plasma [FRAP]; la capacidad de absorbancia de radicales de oxígeno [ORAC] y 2,2ʹ-azino-bis (3-etilbenzotiazolina) -Ácido6-sulfónico) [ABTS]) y marcadores de estrés oxidativo (Oxo-2ʹ-desoxiguanosina (8-OHdG) y F2-isoprostano). Las mujeres que aumentaron la actividad de las enzimas antioxidantes endógenas y la capacidad antioxidante total sérica después del consumo de agraz, en comparación con el placebo,redujeron significativamente los marcadores de estrés oxidativo, el colesterol total, los niveles de colesterol LDL (c-LDL) y el perímetro abdominal, demostrando efectos benéficos en el grupo de mujeres que aumentaron los parámetros antioxidantes luego del consumo de agraz, evidenciando una variabilidad individual en respuesta a la bebida consumida.Universidad de Antioquia. Vicerrectoría de investigación. Comité para el Desarrollo de la Investigación - CODIColombia. Ministerio de Ciencia Tecnología e Innovación - MinicienciasCOL00144769 páginasapplication/pdf - application/epubengTaylor and FrancisAbingdon, Inglaterrahttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndromeMejoras en el estado antioxidante después del consumo de agraz se asociaron con reducciones en factores de riesgo cardiovascular en mujeres con síndrome metabólicoArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionEstrés OxidativoOxidative StressSuperóxido DismutasaSuperoxide DismutaseCatalasaCatalaseGlutatión PeroxidasaGlutathione PeroxidaseAntioxidantesAntioxidantsAndean berryVaccinium meridionalehttps://id.nlm.nih.gov/mesh/D018384https://id.nlm.nih.gov/mesh/D013482https://id.nlm.nih.gov/mesh/D002374https://id.nlm.nih.gov/mesh/D005979https://id.nlm.nih.gov/mesh/D000975CYTA. J. Food.246123819CYTA: Journal of FoodEvaluation of the effects of the Colombian bluebery Vaccinium meridionale Swartz on dyslipidemia, hypertension, inflamation and oxidative stress in men and women with metabolic sydrome / Evaluación de los efectos del consumo de agraz (mortiño) colombiano Vaccinium meridionale Swartz sobre dislipidemias, hipertensión, inflamación y estrés oxidativo en hombres y mujeres con síndrome metabólico111565740563, Contract No. 657-2014 and FP44842-124-2017RoR:03bp5hc83RoR:03fd5ne08PublicationORIGINALBaronaMaria_2021_Improvements_Antioxidant_Status_Agraz.pdfBaronaMaria_2021_Improvements_Antioxidant_Status_Agraz.pdfArtículo de investigaciónapplication/pdf961721https://bibliotecadigital.udea.edu.co/bitstreams/def23679-2c08-40d0-975b-fd780da663b1/download8bd86884bb20a5dd97d0476eecc52f3cMD51trueAnonymousREADBaronaMaria_2021_Improvements_Antioxidant_Status_Agraz.epubBaronaMaria_2021_Improvements_Antioxidant_Status_Agraz.epubArtículo de investigaciónapplication/epub+zip245430https://bibliotecadigital.udea.edu.co/bitstreams/b8ffde79-6c44-41f6-b359-82e70c28a2bc/download06bc33fc4ed5a5814b9afd95f6ee09ddMD52falseAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8927https://bibliotecadigital.udea.edu.co/bitstreams/ffc8c103-805a-4d0f-bb7b-443026d6b584/download1646d1f6b96dbbbc38035efc9239ac9cMD53falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/3d505b91-256f-46df-9cdd-f460fd17eed8/download8a4605be74aa9ea9d79846c1fba20a33MD54falseAnonymousREADTEXTBaronaMaria_2021_Improvements_Antioxidant_Status_Agraz.pdf.txtBaronaMaria_2021_Improvements_Antioxidant_Status_Agraz.pdf.txtExtracted texttext/plain58303https://bibliotecadigital.udea.edu.co/bitstreams/24a92b18-af6a-4151-a134-62385358f6e3/download423ab10422a57ed3de8d063a1f9735baMD55falseAnonymousREADTHUMBNAILBaronaMaria_2021_Improvements_Antioxidant_Status_Agraz.pdf.jpgBaronaMaria_2021_Improvements_Antioxidant_Status_Agraz.pdf.jpgGenerated Thumbnailimage/jpeg11684https://bibliotecadigital.udea.edu.co/bitstreams/485a68dc-8e05-4a19-9395-14070bebaa30/download41161ad1150bdb22353849359c830ec4MD56falseAnonymousREAD10495/41070oai:bibliotecadigital.udea.edu.co:10495/410702025-03-26 20:59:12.45http://creativecommons.org/licenses/by/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |