Improvements in antioxidant status after agraz consumption was associated to reductions in cardiovascular risk factors in women with metabolic syndrome

ABSTRACT: In this study were evaluated the effects of the chronic consumption of agraz (Vaccinium meridio-nale) on antioxidant status and oxidative stress markers in 40 women with metabolic syndrome(MetS) (47.2 ± 9.4 years) through a double-blind, crossover design study, in which participants consumed daily agraz or placebo during 4 weeks, separated by a 4-wk washout period. At the end of each intervention period, endogenous antioxidant enzymes activity, serum total antioxidant capacity (TAC) (ferric reducing ability of plasma [FRAP]; Oxygen Radical Absorbance Capacity[ORAC] and 2,2ʹ-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) [ABTS]), and oxidative stress markers (Oxo-2ʹ-deoxyguanosine (8-OHdG) and F2-isoprostane) were determined. Women who increased endogenous antioxidant enzymes activity and serum TAC after agraz consumption,compared to placebo, significantly reduced oxidative stress markers, total cholesterol, LDL-cho-lesterol (LDL-c) levels, and waist circumference, demonstrating beneficial effects in the group of women in whom antioxidant parameters increased after agraz consumption, evidencing an individual variability in response to the beverage consumed.

• Autores: Marín Echeverri, Catalina; Piedrahita Blandón, Manuela; Galvis Pérez, Yeisson Anibal; Núñez Rangel, Vitelbina; Barona Acevedo, María Jacqueline; Blesso, Christopher N.; Fernández, María Luz
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2021
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/41070
• Acceso en línea: https://hdl.handle.net/10495/41070
• Palabra clave: Estrés Oxidativo; Oxidative Stress; Superóxido Dismutasa; Superoxide Dismutase; Catalasa; Catalase; Glutatión Peroxidasa; Glutathione Peroxidase; Antioxidantes; Antioxidants; Andean berry; Vaccinium meridionale; https://id.nlm.nih.gov/mesh/D018384; https://id.nlm.nih.gov/mesh/D013482; https://id.nlm.nih.gov/mesh/D002374; https://id.nlm.nih.gov/mesh/D005979; https://id.nlm.nih.gov/mesh/D000975
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/