Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome
ABSTRACT: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by venous, arterial, or small-vessel thrombosis and/or pregnancy-related morbidity, associated with persistent positivity of antiphospholipid antibodies (aPL). Pregnancy-related morbidity in APS patients is characterize...
- Autores:
-
Cadavid Jaramillo, Angela Patricia
Velásquez Berrio, Manuela
Fierro Martínez, Juan José
de Leeuw, Karina
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2022
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/43625
- Acceso en línea:
- https://hdl.handle.net/10495/43625
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0897
- Palabra clave:
- Síndrome Antifosfolípido
Antiphospholipid Syndrome
Autoanticuerpos
Autoantibodies
Embarazo
Pregnancy
Pregnancy Complications
Complicaciones del Embarazo
beta 2-Glycoproteína I
beta 2 Glicoprotein I
https://id.nlm.nih.gov/mesh/D016736
https://id.nlm.nih.gov/mesh/D001323
https://id.nlm.nih.gov/mesh/D011247
https://id.nlm.nih.gov/mesh/D011248
https://id.nlm.nih.gov/mesh/D053482
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/2.5/co/
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Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome |
| title |
Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome |
| spellingShingle |
Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome Síndrome Antifosfolípido Antiphospholipid Syndrome Autoanticuerpos Autoantibodies Embarazo Pregnancy Pregnancy Complications Complicaciones del Embarazo beta 2-Glycoproteína I beta 2 Glicoprotein I https://id.nlm.nih.gov/mesh/D016736 https://id.nlm.nih.gov/mesh/D001323 https://id.nlm.nih.gov/mesh/D011247 https://id.nlm.nih.gov/mesh/D011248 https://id.nlm.nih.gov/mesh/D053482 |
| title_short |
Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome |
| title_full |
Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome |
| title_fullStr |
Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome |
| title_full_unstemmed |
Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome |
| title_sort |
Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome |
| dc.creator.fl_str_mv |
Cadavid Jaramillo, Angela Patricia Velásquez Berrio, Manuela Fierro Martínez, Juan José de Leeuw, Karina |
| dc.contributor.author.none.fl_str_mv |
Cadavid Jaramillo, Angela Patricia Velásquez Berrio, Manuela Fierro Martínez, Juan José de Leeuw, Karina |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Investigación en Trombosis Grupo Reproducción |
| dc.subject.decs.none.fl_str_mv |
Síndrome Antifosfolípido Antiphospholipid Syndrome Autoanticuerpos Autoantibodies Embarazo Pregnancy Pregnancy Complications Complicaciones del Embarazo beta 2-Glycoproteína I beta 2 Glicoprotein I |
| topic |
Síndrome Antifosfolípido Antiphospholipid Syndrome Autoanticuerpos Autoantibodies Embarazo Pregnancy Pregnancy Complications Complicaciones del Embarazo beta 2-Glycoproteína I beta 2 Glicoprotein I https://id.nlm.nih.gov/mesh/D016736 https://id.nlm.nih.gov/mesh/D001323 https://id.nlm.nih.gov/mesh/D011247 https://id.nlm.nih.gov/mesh/D011248 https://id.nlm.nih.gov/mesh/D053482 |
| dc.subject.meshuri.none.fl_str_mv |
https://id.nlm.nih.gov/mesh/D016736 https://id.nlm.nih.gov/mesh/D001323 https://id.nlm.nih.gov/mesh/D011247 https://id.nlm.nih.gov/mesh/D011248 https://id.nlm.nih.gov/mesh/D053482 |
| description |
ABSTRACT: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by venous, arterial, or small-vessel thrombosis and/or pregnancy-related morbidity, associated with persistent positivity of antiphospholipid antibodies (aPL). Pregnancy-related morbidity in APS patients is characterized by unexplained fetal deaths, premature birth of morphologically normal newborns, and/or consecutive pregnancy losses before the 10th week of gestation. Beta 2-glycoprotein 1 (ß2GP1) is the main antigen recognized by aPL and plays an essential role in the pathogenesis of APS. Antibodies against ß2GP1 (aß2GP1) are involved in damage-generating mechanisms in APS due to their interaction with trophoblasts, decidua, and endothelial cells. aß2GP1 might be used as a prognostic tool for obstetric risk stratification and ß2GP1 could be a target for molecular-targeted treatment to prevent pregnancy morbidity in APS. This review describes these aspects of aß2GP1, including effects on different cellular targets, its association with the severity of obstetric manifestations and the potential of ß2GP1-targeted therapies for APS. |
| publishDate |
2022 |
| dc.date.issued.none.fl_str_mv |
2022 |
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2024-11-20T14:23:51Z |
| dc.date.available.none.fl_str_mv |
2024-11-20T14:23:51Z |
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Artículo de revisión |
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Fierro JJ, Velásquez M, Cadavid AP, de Leeuw K. Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome. Am J Reprod Immunol. 2022 Jan;87(1):e13509. doi: 10.1111/aji.13509. |
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1046-7408 |
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https://hdl.handle.net/10495/43625 |
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10.1111/aji.13509 |
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1600-0897 |
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http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0897 |
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Fierro JJ, Velásquez M, Cadavid AP, de Leeuw K. Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome. Am J Reprod Immunol. 2022 Jan;87(1):e13509. doi: 10.1111/aji.13509. 1046-7408 10.1111/aji.13509 1600-0897 |
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https://hdl.handle.net/10495/43625 http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0897 |
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eng |
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eng |
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Am J Reprod Immunol |
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11 |
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1 |
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1 |
| dc.relation.citationvolume.spa.fl_str_mv |
87 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
American Journal of Reproductive Immunology |
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Copenhague, Dinamarca |
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Cadavid Jaramillo, Angela PatriciaVelásquez Berrio, ManuelaFierro Martínez, Juan Joséde Leeuw, KarinaGrupo de Investigación en TrombosisGrupo Reproducción2024-11-20T14:23:51Z2024-11-20T14:23:51Z2022Fierro JJ, Velásquez M, Cadavid AP, de Leeuw K. Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndrome. Am J Reprod Immunol. 2022 Jan;87(1):e13509. doi: 10.1111/aji.13509.1046-7408https://hdl.handle.net/10495/4362510.1111/aji.135091600-0897http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0897ABSTRACT: Antiphospholipid syndrome (APS) is an autoimmune disease characterized by venous, arterial, or small-vessel thrombosis and/or pregnancy-related morbidity, associated with persistent positivity of antiphospholipid antibodies (aPL). Pregnancy-related morbidity in APS patients is characterized by unexplained fetal deaths, premature birth of morphologically normal newborns, and/or consecutive pregnancy losses before the 10th week of gestation. Beta 2-glycoprotein 1 (ß2GP1) is the main antigen recognized by aPL and plays an essential role in the pathogenesis of APS. Antibodies against ß2GP1 (aß2GP1) are involved in damage-generating mechanisms in APS due to their interaction with trophoblasts, decidua, and endothelial cells. aß2GP1 might be used as a prognostic tool for obstetric risk stratification and ß2GP1 could be a target for molecular-targeted treatment to prevent pregnancy morbidity in APS. This review describes these aspects of aß2GP1, including effects on different cellular targets, its association with the severity of obstetric manifestations and the potential of ß2GP1-targeted therapies for APS.Colombia. Ministerio de Ciencia, Tecnología e Innovación - MinCienciasCOL0010421COL000763111 páginasapplication/pdfengWiley-BlackwellCopenhague, Dinamarcahttp://creativecommons.org/licenses/by-nc-nd/2.5/co/https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Effects of anti-beta 2-glycoprotein 1 antibodies and its association with pregnancy-related morbidity in antiphospholipid syndromeArtículo de revisiónhttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionSíndrome AntifosfolípidoAntiphospholipid SyndromeAutoanticuerposAutoantibodiesEmbarazoPregnancyPregnancy ComplicationsComplicaciones del Embarazobeta 2-Glycoproteína Ibeta 2 Glicoprotein Ihttps://id.nlm.nih.gov/mesh/D016736https://id.nlm.nih.gov/mesh/D001323https://id.nlm.nih.gov/mesh/D011247https://id.nlm.nih.gov/mesh/D011248https://id.nlm.nih.gov/mesh/D053482Am J Reprod Immunol111187American Journal of Reproductive Immunology1115800762949930-2019757-2016RoR:03fd5ne08PublicationORIGINALCadavidAngela_2021_Effects_Anti-beta2_Glycopretein1.pdfCadavidAngela_2021_Effects_Anti-beta2_Glycopretein1.pdfapplication/pdf787906https://bibliotecadigital.udea.edu.co/bitstreams/bfb0dc8e-b9f5-4885-a258-2bc826217869/downloadecb7b1efbb1fd1376b2fabf845afeeb1MD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; 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