Nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus
ABSTRACT: Triterpene-enriched fractions (OBE100) from Eucalyptus tereticornis demonstrated efficiency when administered intraperitoneally to diet-induced obesity (DIO) mouse model to treat obesity-related type 2 diabetes mellitus (T2DM)1; however, its oral administration has not yet led to satisfact...
- Autores:
-
Escobar Chaves, Elkin Leandro
Acín Martínez, Sergio
Fernández Culma, Maritza
Muñoz, Diana Lorena
Echeverri, Alexandra
Echeverri López, Luis Fernando
Orozco Holguín, Jahir
Balcázar Morales, Norman
- Tipo de recurso:
- http://purl.org/coar/resource_type/c_5794
- Fecha de publicación:
- 2022
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/34757
- Acceso en línea:
- https://hdl.handle.net/10495/34757
- Palabra clave:
- Diabetes Mellitus Tipo 2
Eucalyptus tereticornis
Obesidad
Obesity
Extractos Vegetales
Plant Extracts
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc-sa/4.0/
| id |
UDEA2_9b3b8c4f2072e4c9374d8d1d403ad1bd |
|---|---|
| oai_identifier_str |
oai:bibliotecadigital.udea.edu.co:10495/34757 |
| network_acronym_str |
UDEA2 |
| network_name_str |
Repositorio UdeA |
| repository_id_str |
|
| dc.title.spa.fl_str_mv |
Nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| title |
Nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| spellingShingle |
Nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus Diabetes Mellitus Tipo 2 Eucalyptus tereticornis Obesidad Obesity Extractos Vegetales Plant Extracts |
| title_short |
Nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| title_full |
Nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| title_fullStr |
Nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| title_full_unstemmed |
Nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| title_sort |
Nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitus |
| dc.creator.fl_str_mv |
Escobar Chaves, Elkin Leandro Acín Martínez, Sergio Fernández Culma, Maritza Muñoz, Diana Lorena Echeverri, Alexandra Echeverri López, Luis Fernando Orozco Holguín, Jahir Balcázar Morales, Norman |
| dc.contributor.author.none.fl_str_mv |
Escobar Chaves, Elkin Leandro Acín Martínez, Sergio Fernández Culma, Maritza Muñoz, Diana Lorena Echeverri, Alexandra Echeverri López, Luis Fernando Orozco Holguín, Jahir Balcázar Morales, Norman |
| dc.contributor.conferencename.spa.fl_str_mv |
(22 : Tetrahedron Symposium. Catalysis for Sustainable World : 28 de junio al 1 de julio de 2022 : Lisboa, Portugal) |
| dc.contributor.researchgroup.spa.fl_str_mv |
Genética Molecular (GENMOL) Grupo Tándem Max Planck en Nanobioingeniería Química Orgánica de Productos Naturales |
| dc.subject.decs.none.fl_str_mv |
Diabetes Mellitus Tipo 2 Eucalyptus tereticornis Obesidad Obesity Extractos Vegetales Plant Extracts |
| topic |
Diabetes Mellitus Tipo 2 Eucalyptus tereticornis Obesidad Obesity Extractos Vegetales Plant Extracts |
| description |
ABSTRACT: Triterpene-enriched fractions (OBE100) from Eucalyptus tereticornis demonstrated efficiency when administered intraperitoneally to diet-induced obesity (DIO) mouse model to treat obesity-related type 2 diabetes mellitus (T2DM)1; however, its oral administration has not yet led to satisfactory results. We aimed to develop an oral nano formulation that enhanced the promising effect of the OBE 100 fraction, guaranteeing higher stability and bioavailability of the pharmacologically active components present in the natural extract through the oral route. |
| publishDate |
2022 |
| dc.date.issued.none.fl_str_mv |
2022-06-28 |
| dc.date.accessioned.none.fl_str_mv |
2023-04-25T16:52:08Z |
| dc.date.available.none.fl_str_mv |
2023-04-25T16:52:08Z |
| dc.type.spa.fl_str_mv |
Documento de conferencia |
| dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_c94f |
| dc.type.coar.spa.fl_str_mv |
http://purl.org/coar/resource_type/c_5794 |
| dc.type.redcol.spa.fl_str_mv |
https://purl.org/redcol/resource_type/EC |
| dc.type.coarversion.spa.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.driver.spa.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
| dc.type.version.spa.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
http://purl.org/coar/resource_type/c_5794 |
| status_str |
publishedVersion |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/10495/34757 |
| url |
https://hdl.handle.net/10495/34757 |
| dc.language.iso.spa.fl_str_mv |
eng |
| language |
eng |
| dc.relation.conferencedate.spa.fl_str_mv |
2022-06-28/2022-07-01 |
| dc.relation.conferenceplace.spa.fl_str_mv |
Lisboa, Portugal |
| dc.relation.ispartofjournal.spa.fl_str_mv |
22nd Tetrahedron Symposium. Catalysis for Sustainable World |
| dc.rights.uri.spa.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ |
| dc.rights.uri.*.fl_str_mv |
http://creativecommons.org/licenses/by-nc-sa/2.5/co/ |
| dc.rights.accessrights.spa.fl_str_mv |
info:eu-repo/semantics/openAccess |
| dc.rights.accessrights.*.fl_str_mv |
Atribución-NoComercial-CompartirIgual 2.5 Colombia |
| dc.rights.coar.spa.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0/ http://creativecommons.org/licenses/by-nc-sa/2.5/co/ Atribución-NoComercial-CompartirIgual 2.5 Colombia http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.mimetype.spa.fl_str_mv |
application/pdf |
| dc.publisher.faculty.spa.fl_str_mv |
sin facultad - programa |
| institution |
Universidad de Antioquia |
| bitstream.url.fl_str_mv |
https://bibliotecadigital.udea.edu.co/bitstreams/9bcf44e8-462d-4a55-abb5-f97f89905f8a/download https://bibliotecadigital.udea.edu.co/bitstreams/5ee39723-af46-4ec5-bda4-e651472d2417/download https://bibliotecadigital.udea.edu.co/bitstreams/691ee327-858a-4f8f-9583-86a1995f371b/download https://bibliotecadigital.udea.edu.co/bitstreams/7411df87-2a09-4409-904b-c77ecec55a0c/download https://bibliotecadigital.udea.edu.co/bitstreams/03cbc425-972a-4849-9c39-96cb4542ecd0/download |
| bitstream.checksum.fl_str_mv |
19018fc25fd8b6b419315739363b1527 e2060682c9c70d4d30c83c51448f4eed 8a4605be74aa9ea9d79846c1fba20a33 e5cb31e8b601b27ef404f46f3aebd909 c2a9dcc88ba18a23e9a2168dbec3f3bc |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositorio Institucional de la Universidad de Antioquia |
| repository.mail.fl_str_mv |
aplicacionbibliotecadigitalbiblioteca@udea.edu.co |
| _version_ |
1851052424356167680 |
| spelling |
Escobar Chaves, Elkin LeandroAcín Martínez, SergioFernández Culma, MaritzaMuñoz, Diana LorenaEcheverri, AlexandraEcheverri López, Luis FernandoOrozco Holguín, JahirBalcázar Morales, Norman(22 : Tetrahedron Symposium. Catalysis for Sustainable World : 28 de junio al 1 de julio de 2022 : Lisboa, Portugal)Genética Molecular (GENMOL)Grupo Tándem Max Planck en NanobioingenieríaQuímica Orgánica de Productos Naturales2023-04-25T16:52:08Z2023-04-25T16:52:08Z2022-06-28https://hdl.handle.net/10495/34757ABSTRACT: Triterpene-enriched fractions (OBE100) from Eucalyptus tereticornis demonstrated efficiency when administered intraperitoneally to diet-induced obesity (DIO) mouse model to treat obesity-related type 2 diabetes mellitus (T2DM)1; however, its oral administration has not yet led to satisfactory results. We aimed to develop an oral nano formulation that enhanced the promising effect of the OBE 100 fraction, guaranteeing higher stability and bioavailability of the pharmacologically active components present in the natural extract through the oral route.COL0006723COL0015339COL0202529application/pdfenghttps://creativecommons.org/licenses/by-nc-sa/4.0/http://creativecommons.org/licenses/by-nc-sa/2.5/co/info:eu-repo/semantics/openAccessAtribución-NoComercial-CompartirIgual 2.5 Colombiahttp://purl.org/coar/access_right/c_abf2Nanoformulation prototype based on a natural extract for the potential treatment of type 2 diabetes mellitusDocumento de conferenciahttp://purl.org/coar/resource_type/c_5794http://purl.org/coar/resource_type/c_c94fhttps://purl.org/redcol/resource_type/EChttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionDiabetes Mellitus Tipo 2Eucalyptus tereticornisObesidadObesityExtractos VegetalesPlant Extractssin facultad - programa2022-06-28/2022-07-01Lisboa, Portugal22nd Tetrahedron Symposium. Catalysis for Sustainable WorldPublicationORIGINALEscobarElkin_2022_Nanoformulation.pdfEscobarElkin_2022_Nanoformulation.pdfPósterapplication/pdf1573372https://bibliotecadigital.udea.edu.co/bitstreams/9bcf44e8-462d-4a55-abb5-f97f89905f8a/download19018fc25fd8b6b419315739363b1527MD51trueAnonymousREADCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-81051https://bibliotecadigital.udea.edu.co/bitstreams/5ee39723-af46-4ec5-bda4-e651472d2417/downloade2060682c9c70d4d30c83c51448f4eedMD52falseAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/691ee327-858a-4f8f-9583-86a1995f371b/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTEscobarElkin_2022_Nanoformulation.pdf.txtEscobarElkin_2022_Nanoformulation.pdf.txtExtracted texttext/plain10481https://bibliotecadigital.udea.edu.co/bitstreams/7411df87-2a09-4409-904b-c77ecec55a0c/downloade5cb31e8b601b27ef404f46f3aebd909MD54falseAnonymousREADTHUMBNAILEscobarElkin_2022_Nanoformulation.pdf.jpgEscobarElkin_2022_Nanoformulation.pdf.jpgGenerated Thumbnailimage/jpeg21781https://bibliotecadigital.udea.edu.co/bitstreams/03cbc425-972a-4849-9c39-96cb4542ecd0/downloadc2a9dcc88ba18a23e9a2168dbec3f3bcMD55falseAnonymousREAD10495/34757oai:bibliotecadigital.udea.edu.co:10495/347572025-03-26 22:08:14.087https://creativecommons.org/licenses/by-nc-sa/4.0/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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 |