β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice
ABSTRACT: β-site APP cleaving enzyme 1 (BACE1) initiates APP cleavage, which has been reported to be an inducer of tau pathology by altering proteasome functions in Alzheimer’s disease (AD). However, the exact relationship between BACE1 and PHF (Paired Helical Filaments) formation is not clear. In t...
- Autores:
-
Piedrahita, Diego
Castro Álvarez, John Fredy
Boudreau, Ryan L.
Villegas Lanau, Carlos Andrés
Kosik, Kenneth S.
Gallego Gómez, Juan Carlos
Cardona Gómez, Gloria Patricia
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2016
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/25854
- Acceso en línea:
- http://hdl.handle.net/10495/25854
- Palabra clave:
- Enfermedad de Alzheimer
Alzheimer Disease
Autofagia
Autophagy
β-secretase 1
Chaperones
Lipid rafts
Tauopatía
Tauopathy
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by/4.0/