Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder
ABSTRACT: Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating severe BP (BP-I). By analyzing actigraphy dat...
- Autores:
-
Gómez Makhinson, Juliana
López Tobón, María Cecilia
Montoya Montoya, Gabriel
Montoya Guerra, Claudia Patricia
Ospina Duque, Jorge
López Jaramillo, Carlos Alberto
Pagani, Lucia
Clair, Patricia
Teshiba, Terri
Service, Susan
Fears, Scott
Araya, Carmen
Araya, Xinia
Bejarano, Julio
Ramírez, Margarita
Castrillón, Gabriel
Aldana, Ileana
Navarro, Linda
Freimer, Daniel
Safaie, Brian
Keung, Lap Woon
Greenspan, Kiefer
Chou, Katty
Escobar, Javier
Kremeyer, Barbara
Ruiz Linares, Andrés
Cantor, Rita
Macaya, Gabriel
Molina, Julio
Reus, Victor
Sabatti, Chiara
Bearden, Carrie
Takahashi, Joseph
Freimer, Nelson
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2015
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- eng
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/19266
- Acceso en línea:
- http://hdl.handle.net/10495/19266
- Palabra clave:
- Trastorno Bipolar
Bipolar disorder
Endofenotipos
Endophenotypes
Ritmo Circadiano
Circadian rhythms
Actigrafía
Actigraphy
Conducta
Behavior
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
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| dc.title.spa.fl_str_mv |
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder |
| title |
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder |
| spellingShingle |
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder Trastorno Bipolar Bipolar disorder Endofenotipos Endophenotypes Ritmo Circadiano Circadian rhythms Actigrafía Actigraphy Conducta Behavior |
| title_short |
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder |
| title_full |
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder |
| title_fullStr |
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder |
| title_full_unstemmed |
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder |
| title_sort |
Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder |
| dc.creator.fl_str_mv |
Gómez Makhinson, Juliana López Tobón, María Cecilia Montoya Montoya, Gabriel Montoya Guerra, Claudia Patricia Ospina Duque, Jorge López Jaramillo, Carlos Alberto Pagani, Lucia Clair, Patricia Teshiba, Terri Service, Susan Fears, Scott Araya, Carmen Araya, Xinia Bejarano, Julio Ramírez, Margarita Castrillón, Gabriel Aldana, Ileana Navarro, Linda Freimer, Daniel Safaie, Brian Keung, Lap Woon Greenspan, Kiefer Chou, Katty Escobar, Javier Kremeyer, Barbara Ruiz Linares, Andrés Cantor, Rita Macaya, Gabriel Molina, Julio Reus, Victor Sabatti, Chiara Bearden, Carrie Takahashi, Joseph Freimer, Nelson |
| dc.contributor.author.none.fl_str_mv |
Gómez Makhinson, Juliana López Tobón, María Cecilia Montoya Montoya, Gabriel Montoya Guerra, Claudia Patricia Ospina Duque, Jorge López Jaramillo, Carlos Alberto Pagani, Lucia Clair, Patricia Teshiba, Terri Service, Susan Fears, Scott Araya, Carmen Araya, Xinia Bejarano, Julio Ramírez, Margarita Castrillón, Gabriel Aldana, Ileana Navarro, Linda Freimer, Daniel Safaie, Brian Keung, Lap Woon Greenspan, Kiefer Chou, Katty Escobar, Javier Kremeyer, Barbara Ruiz Linares, Andrés Cantor, Rita Macaya, Gabriel Molina, Julio Reus, Victor Sabatti, Chiara Bearden, Carrie Takahashi, Joseph Freimer, Nelson |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo de Investigación en Psiquiatría (GIPSI) |
| dc.subject.decs.none.fl_str_mv |
Trastorno Bipolar Bipolar disorder Endofenotipos Endophenotypes Ritmo Circadiano Circadian rhythms Actigrafía Actigraphy Conducta Behavior |
| topic |
Trastorno Bipolar Bipolar disorder Endofenotipos Endophenotypes Ritmo Circadiano Circadian rhythms Actigrafía Actigraphy Conducta Behavior |
| description |
ABSTRACT: Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating severe BP (BP-I). By analyzing actigraphy data obtained from members of 26 Costa Rican and Colombian pedigrees [136 euthymic (i.e., interepisode) BP-I individuals and 422 non–BP-I relatives], we delineated 73 phenotypes, of which 49 demonstrated significant heritability and 13 showed significant trait-like association with BP-I. All BP-I–associated traits related to activity level, with BP-I individuals consistently demonstrating lower activity levels than their non–BP-I relatives. We analyzed all 49 heritable phenotypes using genetic linkage analysis, with special emphasis on phenotypes judged to have the strongest impact on the biology underlying BP. We identified a locus for interdaily stability of activity, at a threshold exceeding genome-wide significance, on chromosome 12pter, a region that also showed pleiotropic linkage to two additional activity phenotypes. |
| publishDate |
2015 |
| dc.date.issued.none.fl_str_mv |
2015 |
| dc.date.accessioned.none.fl_str_mv |
2021-04-08T18:19:24Z |
| dc.date.available.none.fl_str_mv |
2021-04-08T18:19:24Z |
| dc.type.spa.fl_str_mv |
Artículo de investigación |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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info:eu-repo/semantics/article |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
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Pagani L, St Clair PA, Teshiba TM, Service SK, Fears SC, Araya C, Araya X, Bejarano J, Ramirez M, Castrillón G, Gomez-Makhinson J, Lopez MC, Montoya G, Montoya CP, Aldana I, Navarro L, Freimer DG, Safaie B, Keung LW, Greenspan K, Chou K, Escobar JI, Ospina-Duque J, Kremeyer B, Ruiz-Linares A, Cantor RM, Lopez-Jaramillo C, Macaya G, Molina J, Reus VI, Sabatti C, Bearden CE, Takahashi JS, Freimer NB. Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder. Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E754-61. doi: 10.1073/pnas.1513525113. |
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0369-8211 |
| dc.identifier.uri.none.fl_str_mv |
http://hdl.handle.net/10495/19266 |
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10.1073/pnas.1513525113 |
| dc.identifier.eissn.none.fl_str_mv |
2250-1746 |
| identifier_str_mv |
Pagani L, St Clair PA, Teshiba TM, Service SK, Fears SC, Araya C, Araya X, Bejarano J, Ramirez M, Castrillón G, Gomez-Makhinson J, Lopez MC, Montoya G, Montoya CP, Aldana I, Navarro L, Freimer DG, Safaie B, Keung LW, Greenspan K, Chou K, Escobar JI, Ospina-Duque J, Kremeyer B, Ruiz-Linares A, Cantor RM, Lopez-Jaramillo C, Macaya G, Molina J, Reus VI, Sabatti C, Bearden CE, Takahashi JS, Freimer NB. Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder. Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E754-61. doi: 10.1073/pnas.1513525113. 0369-8211 10.1073/pnas.1513525113 2250-1746 |
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http://hdl.handle.net/10495/19266 |
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eng |
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eng |
| dc.relation.ispartofjournalabbrev.spa.fl_str_mv |
Proc. Natl. Acad. Sci. U. S. A. |
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761 |
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6 |
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754 |
| dc.relation.citationvolume.spa.fl_str_mv |
113 |
| dc.relation.ispartofjournal.spa.fl_str_mv |
Proceedings of the National Academy of Sciences, India. Section B |
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Washington, Estados Unidos |
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Gómez Makhinson, JulianaLópez Tobón, María CeciliaMontoya Montoya, GabrielMontoya Guerra, Claudia PatriciaOspina Duque, JorgeLópez Jaramillo, Carlos AlbertoPagani, LuciaClair, PatriciaTeshiba, TerriService, SusanFears, ScottAraya, CarmenAraya, XiniaBejarano, JulioRamírez, MargaritaCastrillón, GabrielAldana, IleanaNavarro, LindaFreimer, DanielSafaie, BrianKeung, Lap WoonGreenspan, KieferChou, KattyEscobar, JavierKremeyer, BarbaraRuiz Linares, AndrésCantor, RitaMacaya, GabrielMolina, JulioReus, VictorSabatti, ChiaraBearden, CarrieTakahashi, JosephFreimer, NelsonGrupo de Investigación en Psiquiatría (GIPSI)2021-04-08T18:19:24Z2021-04-08T18:19:24Z2015Pagani L, St Clair PA, Teshiba TM, Service SK, Fears SC, Araya C, Araya X, Bejarano J, Ramirez M, Castrillón G, Gomez-Makhinson J, Lopez MC, Montoya G, Montoya CP, Aldana I, Navarro L, Freimer DG, Safaie B, Keung LW, Greenspan K, Chou K, Escobar JI, Ospina-Duque J, Kremeyer B, Ruiz-Linares A, Cantor RM, Lopez-Jaramillo C, Macaya G, Molina J, Reus VI, Sabatti C, Bearden CE, Takahashi JS, Freimer NB. Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder. Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):E754-61. doi: 10.1073/pnas.1513525113.0369-8211http://hdl.handle.net/10495/1926610.1073/pnas.15135251132250-1746ABSTRACT: Abnormalities in sleep and circadian rhythms are central features of bipolar disorder (BP), often persisting between episodes. We report here, to our knowledge, the first systematic analysis of circadian rhythm activity in pedigrees segregating severe BP (BP-I). By analyzing actigraphy data obtained from members of 26 Costa Rican and Colombian pedigrees [136 euthymic (i.e., interepisode) BP-I individuals and 422 non–BP-I relatives], we delineated 73 phenotypes, of which 49 demonstrated significant heritability and 13 showed significant trait-like association with BP-I. All BP-I–associated traits related to activity level, with BP-I individuals consistently demonstrating lower activity levels than their non–BP-I relatives. We analyzed all 49 heritable phenotypes using genetic linkage analysis, with special emphasis on phenotypes judged to have the strongest impact on the biology underlying BP. We identified a locus for interdaily stability of activity, at a threshold exceeding genome-wide significance, on chromosome 12pter, a region that also showed pleiotropic linkage to two additional activity phenotypes.COL00291478application/pdfengCouncil of the National Academy of SciencesWashington, Estados Unidoshttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorderArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTrastorno BipolarBipolar disorderEndofenotiposEndophenotypesRitmo CircadianoCircadian rhythmsActigrafíaActigraphyConductaBehaviorProc. Natl. Acad. Sci. U. S. A.7616754113Proceedings of the National Academy of Sciences, India. 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