IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort

ABSTRACT: Higher IL-21 levels were associated with natural resistance to HIV infection in an Italian cohort. Thus we wanted to confirm such association in HIV exposed seronegative individuals (HESN) from Colombia. Cells from HESN were less susceptible to infection and expressed higher IL-21 mRNA lev...

Full description

Autores:
Serna Ortega, Paula Andrea
Aguilar Jiménez, Wbeimar
Florez Álvarez, Lizdany
Trabattoni, Daria
Rúgeles López, María Teresa
Biasin, Mara
Tipo de recurso:
Article of investigation
Fecha de publicación:
2020
Institución:
Universidad de Antioquia
Repositorio:
Repositorio UdeA
Idioma:
eng
OAI Identifier:
oai:bibliotecadigital.udea.edu.co:10495/35970
Acceso en línea:
https://hdl.handle.net/10495/35970
Palabra clave:
Receptores de Interleucina-21
Receptors, Interleukin-21
Síndrome de Inmunodeficiencia Adquirida
Acquired Immunodeficiency Syndrome
Citocinas
Cytokines
Enfermedades del Sistema Inmune
Immune System Diseases
Rights
openAccess
License
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
id UDEA2_91fbe754704177dd5966cd17084460a5
oai_identifier_str oai:bibliotecadigital.udea.edu.co:10495/35970
network_acronym_str UDEA2
network_name_str Repositorio UdeA
repository_id_str
dc.title.spa.fl_str_mv IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort
title IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort
spellingShingle IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort
Receptores de Interleucina-21
Receptors, Interleukin-21
Síndrome de Inmunodeficiencia Adquirida
Acquired Immunodeficiency Syndrome
Citocinas
Cytokines
Enfermedades del Sistema Inmune
Immune System Diseases
title_short IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort
title_full IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort
title_fullStr IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort
title_full_unstemmed IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort
title_sort IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort
dc.creator.fl_str_mv Serna Ortega, Paula Andrea
Aguilar Jiménez, Wbeimar
Florez Álvarez, Lizdany
Trabattoni, Daria
Rúgeles López, María Teresa
Biasin, Mara
dc.contributor.author.none.fl_str_mv Serna Ortega, Paula Andrea
Aguilar Jiménez, Wbeimar
Florez Álvarez, Lizdany
Trabattoni, Daria
Rúgeles López, María Teresa
Biasin, Mara
dc.contributor.researchgroup.spa.fl_str_mv Inmunovirología
dc.subject.decs.none.fl_str_mv Receptores de Interleucina-21
Receptors, Interleukin-21
Síndrome de Inmunodeficiencia Adquirida
Acquired Immunodeficiency Syndrome
Citocinas
Cytokines
Enfermedades del Sistema Inmune
Immune System Diseases
topic Receptores de Interleucina-21
Receptors, Interleukin-21
Síndrome de Inmunodeficiencia Adquirida
Acquired Immunodeficiency Syndrome
Citocinas
Cytokines
Enfermedades del Sistema Inmune
Immune System Diseases
description ABSTRACT: Higher IL-21 levels were associated with natural resistance to HIV infection in an Italian cohort. Thus we wanted to confirm such association in HIV exposed seronegative individuals (HESN) from Colombia. Cells from HESN were less susceptible to infection and expressed higher IL-21 mRNA levels than healthy controls at both baseline and 7-days post-infection; similar results were observed for IL-6, perforin, and granzyme. These results suggest that IL-21/IL-6 increase may be a distinctive quality in the profile of HIV 1 resistance, at least during sexual exposure. However, further studies are necessary to confirm the specific protective mechanisms of these cytokines.
publishDate 2020
dc.date.issued.none.fl_str_mv 2020
dc.date.accessioned.none.fl_str_mv 2023-07-19T19:43:20Z
dc.date.available.none.fl_str_mv 2023-07-19T19:43:20Z
dc.type.spa.fl_str_mv Artículo de investigación
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.redcol.spa.fl_str_mv https://purl.org/redcol/resource_type/ARTCORT
dc.type.coarversion.spa.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_2df8fbb1
status_str publishedVersion
dc.identifier.citation.spa.fl_str_mv Serna-Ortega PA, Aguilar-Jimenez W, Florez-Álvarez L, Trabattoni D, Rugeles MT, Biasin M. IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort. Microbes Infect. 2020 Sep;22(8):371-374. doi: 10.1016/j.micinf.2019.11.002. Epub 2019 Dec 7. PMID: 31816393.
dc.identifier.issn.none.fl_str_mv 1286-4579
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10495/35970
dc.identifier.doi.none.fl_str_mv 10.1016/j.micinf.2019.11.002
dc.identifier.eissn.none.fl_str_mv 1769-714X
identifier_str_mv Serna-Ortega PA, Aguilar-Jimenez W, Florez-Álvarez L, Trabattoni D, Rugeles MT, Biasin M. IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort. Microbes Infect. 2020 Sep;22(8):371-374. doi: 10.1016/j.micinf.2019.11.002. Epub 2019 Dec 7. PMID: 31816393.
1286-4579
10.1016/j.micinf.2019.11.002
1769-714X
url https://hdl.handle.net/10495/35970
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.ispartofjournalabbrev.spa.fl_str_mv Microbes Infect.
dc.relation.citationendpage.spa.fl_str_mv 374
dc.relation.citationstartpage.spa.fl_str_mv 371
dc.relation.citationvolume.spa.fl_str_mv 22
dc.relation.ispartofjournal.spa.fl_str_mv Microbes and infection
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
https://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.spa.fl_str_mv 3
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier
dc.publisher.place.spa.fl_str_mv Estados Unidos
institution Universidad de Antioquia
bitstream.url.fl_str_mv https://bibliotecadigital.udea.edu.co/bitstreams/b74f042f-32da-4237-a645-e4d2353f41f3/download
https://bibliotecadigital.udea.edu.co/bitstreams/e40fd8e9-3356-4ac9-846e-bfe73763151f/download
https://bibliotecadigital.udea.edu.co/bitstreams/c702dd2b-54b4-4b52-a508-0be463c5c00d/download
https://bibliotecadigital.udea.edu.co/bitstreams/9c47b91c-716e-4a43-8993-21fc18a3bed5/download
https://bibliotecadigital.udea.edu.co/bitstreams/9cf45aa5-0fc9-46cc-9a94-00d3419c01ed/download
bitstream.checksum.fl_str_mv b88b088d9957e670ce3b3fbe2eedbc13
f1111b173558ca8528a3135e0e844821
8a4605be74aa9ea9d79846c1fba20a33
927dd874f00a5aa5a2de3c0c5064387a
9d1e0ceaaa667d42e9844457653155b4
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional de la Universidad de Antioquia
repository.mail.fl_str_mv aplicacionbibliotecadigitalbiblioteca@udea.edu.co
_version_ 1851052345391054848
spelling Serna Ortega, Paula AndreaAguilar Jiménez, WbeimarFlorez Álvarez, LizdanyTrabattoni, DariaRúgeles López, María TeresaBiasin, MaraInmunovirología2023-07-19T19:43:20Z2023-07-19T19:43:20Z2020Serna-Ortega PA, Aguilar-Jimenez W, Florez-Álvarez L, Trabattoni D, Rugeles MT, Biasin M. IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort. Microbes Infect. 2020 Sep;22(8):371-374. doi: 10.1016/j.micinf.2019.11.002. Epub 2019 Dec 7. PMID: 31816393.1286-4579https://hdl.handle.net/10495/3597010.1016/j.micinf.2019.11.0021769-714XABSTRACT: Higher IL-21 levels were associated with natural resistance to HIV infection in an Italian cohort. Thus we wanted to confirm such association in HIV exposed seronegative individuals (HESN) from Colombia. Cells from HESN were less susceptible to infection and expressed higher IL-21 mRNA levels than healthy controls at both baseline and 7-days post-infection; similar results were observed for IL-6, perforin, and granzyme. These results suggest that IL-21/IL-6 increase may be a distinctive quality in the profile of HIV 1 resistance, at least during sexual exposure. However, further studies are necessary to confirm the specific protective mechanisms of these cytokines.COL00124443application/pdfengElsevierEstados Unidoshttp://creativecommons.org/licenses/by-nc-nd/2.5/co/https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohortArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTCORThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionReceptores de Interleucina-21Receptors, Interleukin-21Síndrome de Inmunodeficiencia AdquiridaAcquired Immunodeficiency SyndromeCitocinasCytokinesEnfermedades del Sistema InmuneImmune System DiseasesMicrobes Infect.37437122Microbes and infectionPublicationCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8823https://bibliotecadigital.udea.edu.co/bitstreams/b74f042f-32da-4237-a645-e4d2353f41f3/downloadb88b088d9957e670ce3b3fbe2eedbc13MD52falseAnonymousREADORIGINALAguilarWbeimar_2019_IL21AssociatedNaturalResistanceHIV1.pdfAguilarWbeimar_2019_IL21AssociatedNaturalResistanceHIV1.pdfArtículo de investigaciónapplication/pdf605198https://bibliotecadigital.udea.edu.co/bitstreams/e40fd8e9-3356-4ac9-846e-bfe73763151f/downloadf1111b173558ca8528a3135e0e844821MD51trueAnonymousREADLICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://bibliotecadigital.udea.edu.co/bitstreams/c702dd2b-54b4-4b52-a508-0be463c5c00d/download8a4605be74aa9ea9d79846c1fba20a33MD53falseAnonymousREADTEXTAguilarWbeimar_2019_IL21AssociatedNaturalResistanceHIV1.pdf.txtAguilarWbeimar_2019_IL21AssociatedNaturalResistanceHIV1.pdf.txtExtracted texttext/plain22595https://bibliotecadigital.udea.edu.co/bitstreams/9c47b91c-716e-4a43-8993-21fc18a3bed5/download927dd874f00a5aa5a2de3c0c5064387aMD54falseAnonymousREADTHUMBNAILAguilarWbeimar_2019_IL21AssociatedNaturalResistanceHIV1.pdf.jpgAguilarWbeimar_2019_IL21AssociatedNaturalResistanceHIV1.pdf.jpgGenerated Thumbnailimage/jpeg15352https://bibliotecadigital.udea.edu.co/bitstreams/9cf45aa5-0fc9-46cc-9a94-00d3419c01ed/download9d1e0ceaaa667d42e9844457653155b4MD55falseAnonymousREAD10495/35970oai:bibliotecadigital.udea.edu.co:10495/359702025-03-26 20:55:12.638http://creativecommons.org/licenses/by-nc-nd/2.5/co/open.accesshttps://bibliotecadigital.udea.edu.coRepositorio Institucional de la Universidad de Antioquiaaplicacionbibliotecadigitalbiblioteca@udea.edu.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

Publicaciones similares