ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans

ABSTRACT: Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.

• Autores: Bedoya Berrío, Gabriel de Jesús; Ruíz Linares, Andrés; Marcelain, Katherine; Barahona Ponce, Carol; Baez Benavides, Pablo F.; Müller, Bettina; de Toro, Gonzalo; Retamales, Javier; Barajas, Olga; Ahumada, Monica; Morales, Erik; Rojas, Armando; Sanhueza, Verónica; Loader, Denisse; Rivera, María Teresa; Gutiérrez, Lorena; Bernal, Giuliano; Ortega, Alejandro; Montalvo, Domingo; Portiño, Sergio; Bertrán, Maria Enriqueta; Gabler, Fernando; Spencer, Loreto; Olloquequi, Jordi; González Silos, Rosa; Fischer, Christine; Scherer, Dominique; Jenab, Mazda; Aleksandrova, Krasimira; Katzke, Verena; Weiderpass, Elisabete; Moradi, Tahereh; Fischer, Krista; Bossers, Willem; Brenner, Hermann; Hveem, Kristian; Eklund, Niina; Völker, Uwe; Waldenberger, Melanie; Fuentes Guajardo, Macarena; González José, Rolando; Bortolini, Maria C.; Canizales, Samuel; Gallo, Carla; Boekstegers, Felix; Rothhammer, Francisco; Bermejo, Justo Lorenzo
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2020
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/41106
• Acceso en línea: https://hdl.handle.net/10495/41106
• Palabra clave: ATP Binding Cassette Transporter, Subfamily B; Subfamilia B de Transportador de Casetes de Unión a ATP; Case-Control Studies; Estudios de Casos y Controles; Gallbladder Neoplasms; Neoplasias de la Vesícula Biliar; Genetic Association Studies; Estudios de Asociación Genética; Genetic Predisposition to Disease; Predisposición Genética a la Enfermedad; Polymorphism, Single Nucleotide; Polimorfismo de Nucleótido Simple; Prospective Studies; Estudios Prospectivos; Retrospective Studies; Estudios Retrospectivos; Indians, South American; Indígenas Sudamericanos; Población Blanca; White People; https://id.nlm.nih.gov/mesh/D018435; https://id.nlm.nih.gov/mesh/D016022; https://id.nlm.nih.gov/mesh/D005706; https://id.nlm.nih.gov/mesh/D056726; https://id.nlm.nih.gov/mesh/D020022; https://id.nlm.nih.gov/mesh/D020641; https://id.nlm.nih.gov/mesh/D011446; https://id.nlm.nih.gov/mesh/D012189; https://id.nlm.nih.gov/mesh/D007199; https://id.nlm.nih.gov/mesh/D044465
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/