Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia
ABSTARCT: The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulf...
- Autores:
-
Galvis Ramírez, Manuel Fernando
Quintana Castillo, Juan Carlos
Bueno Sanchez, Julio Cesar
- Tipo de recurso:
- Review article
- Fecha de publicación:
- 2018
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/12981
- Acceso en línea:
- http://hdl.handle.net/10495/12981
- Palabra clave:
- Glomerular Endothelia Dysfunction
Preeclampsia
Heparan Sulfate (HS)
Systemic Inflammatory Response
Renal Damage
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by/2.5/co/
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Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| title |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| spellingShingle |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia Glomerular Endothelia Dysfunction Preeclampsia Heparan Sulfate (HS) Systemic Inflammatory Response Renal Damage |
| title_short |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| title_full |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| title_fullStr |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| title_full_unstemmed |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| title_sort |
Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia |
| dc.creator.fl_str_mv |
Galvis Ramírez, Manuel Fernando Quintana Castillo, Juan Carlos Bueno Sanchez, Julio Cesar |
| dc.contributor.author.none.fl_str_mv |
Galvis Ramírez, Manuel Fernando Quintana Castillo, Juan Carlos Bueno Sanchez, Julio Cesar |
| dc.contributor.researchgroup.spa.fl_str_mv |
Grupo Reproducción |
| dc.subject.none.fl_str_mv |
Glomerular Endothelia Dysfunction Preeclampsia Heparan Sulfate (HS) Systemic Inflammatory Response Renal Damage |
| topic |
Glomerular Endothelia Dysfunction Preeclampsia Heparan Sulfate (HS) Systemic Inflammatory Response Renal Damage |
| description |
ABSTARCT: The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulfated domains that occur along the polysaccharide chain, as evidenced by fact that release of fragments of heparan sulfate by heparanase significantly increases the permeability of albumin passage through the glomerular endothelium, event that originates proteinuria. This review aims to show the importance of the structural domains of heparan sulfate in the process of selective permeability and to demonstrate how these domains may be altered during the glomerular inflammation processes that occur in preeclampsia. |
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2018 |
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2018 |
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2020-01-10T17:27:55Z |
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2020-01-10T17:27:55Z |
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Galvis-Ramírez MF, Quintana-Castillo JC, Bueno-Sánchez JC. Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Front. Physiol. 2018;9:1470. doi: 10.3389/fphys.2018.01470 |
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http://hdl.handle.net/10495/12981 |
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10.3389/fphys.2018.01470 |
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1664-042X |
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Galvis-Ramírez MF, Quintana-Castillo JC, Bueno-Sánchez JC. Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Front. Physiol. 2018;9:1470. doi: 10.3389/fphys.2018.01470 10.3389/fphys.2018.01470 1664-042X |
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Front Physiol |
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Frontiers in Physiology |
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Galvis Ramírez, Manuel FernandoQuintana Castillo, Juan CarlosBueno Sanchez, Julio CesarGrupo Reproducción2020-01-10T17:27:55Z2020-01-10T17:27:55Z2018Galvis-Ramírez MF, Quintana-Castillo JC, Bueno-Sánchez JC. Novel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in Preeclampsia. Front. Physiol. 2018;9:1470. doi: 10.3389/fphys.2018.01470http://hdl.handle.net/10495/1298110.3389/fphys.2018.014701664-042XABSTARCT: The polysaccharide heparan sulfate is ubiquitously expressed as a proteoglycan in extracellular matrices and on cell surfaces. In the glomerular filtration barrier, the action of the heparan sulfate is directly related to the function of glomerular filtration, mostly attributed to the sulfated domains that occur along the polysaccharide chain, as evidenced by fact that release of fragments of heparan sulfate by heparanase significantly increases the permeability of albumin passage through the glomerular endothelium, event that originates proteinuria. This review aims to show the importance of the structural domains of heparan sulfate in the process of selective permeability and to demonstrate how these domains may be altered during the glomerular inflammation processes that occur in preeclampsia.9application/pdfspaFrontiers Research FoundationSuizahttp://creativecommons.org/licenses/by/2.5/co/https://creativecommons.org/licenses/by/4.0/Atribución 2.5info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Glomerular Endothelia DysfunctionPreeclampsiaHeparan Sulfate (HS)Systemic Inflammatory ResponseRenal DamageNovel Insights Into the Role of Glycans in the Pathophysiology of Glomerular Endotheliosis in PreeclampsiaArtículo de revisiónhttp://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionFront Physiol10147019Frontiers in PhysiologyPublicationORIGINALGalvisManuel_2018_GlycansGlomerularPreeclapsia.pdfGalvisManuel_2018_GlycansGlomerularPreeclapsia.pdfArtículo de revisiónapplication/pdf1144101https://bibliotecadigital.udea.edu.co/bitstreams/25c08637-3e6f-4852-86ff-ea5bb38dff72/download7bf0e27d3e2ff35e3b8b32941a318ef5MD53trueAnonymousREADCC-LICENSElicense_urllicense_urltext/plain; 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