Follicular CD8 + T Cells : Origin, Fuction and Importance During HIV Infection

ABSTRACT: The lymphoid follicle is critical for the development of humoral immune responses. Cell circulation to this site is highly regulated by the differential expression of chemokine receptors. This feature contributes to the establishment of viral reservoirs in lymphoid follicles and the development of some types of malignancies that are able to evade immune surveillance, especially conventional CD8+ T cells. Interestingly, a subtype of CD8+ T cells located within the lymphoid follicle (follicular CD8+ T cells) was recently described; these cells have been proposed to play an important role in viral and tumor control, as well as to modulate humoral and T follicular helper cell responses. In this review, we summarize the knowledge on this novel CD8+ T cell population, its origin, function, and potential role in health and disease, in particular, in the context of the infection by the human immunodeficiency virus.

• Autores: Perdomo Celis, Federico; Taborda Vanegas, Natalia Andrea; Rugeles López, María Teresa
• Tipo de recurso: Review article
• Fecha de publicación: 2017
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/34010
• Acceso en línea: https://hdl.handle.net/10495/34010; https://www.frontiersin.org/articles/10.3389/fimmu.2017.01241/full
• Palabra clave: Linfocitos T; T-Lymphocytes; Linfocitos B; B-Lymphocytes; T-Lymphocytes, Cytotoxic; Linfocitos T Citotóxicos; CD8 Antigens; Antígenos CD8; Receptors, CXCR5; Receptores CXCR5
• Rights: openAccess
• License: https://creativecommons.org/licenses/by/4.0/