Gm and Km allotypes and Typhoid Fever

ABSTRACT: Gm and Km allotypes of immunoglobulins were determined in children with typhoid fever (Cases), in children without infectious diseases (Con-1), and in children with fever but no Salmonella in their blood or bone marrow (Con-2). Children were sampled from the urban population of Santiago; and they belonged to the low and low-middle socioeconomic strata. Cases had a higher frequency of [f;(-);b1,b3 or 3;(-);5,13] G1m, G2m, G3m haplotype than Con-1 and Con-2. Con-1 and Con-2 did not differ in their Gm haplotype or Km allele frequencies, but they differed in phenotype distribution. Con-1 deviated from Hardy-Weinberg equilibrium for Km due to a lack of Km 1-1 homozygotes. The relationship among these results, the ethnic origin of Chileans, and the differential susceptibility to typhoid fever are discussed.

• Autores: Arcos Burgos, Oscar Mauricio; Herrera, Patricio; Valenzuela, Carlos; Pandey, Janardan
• Tipo de recurso: Article of investigation
• Fecha de publicación: 1996
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/42322
• Acceso en línea: https://hdl.handle.net/10495/42322
• Palabra clave: Adolescente; Adolescent; Análisis de Varianza; Analysis of Variance; Estudios de Casos y Controles; Case-Control Studies; Fiebre Tifoidea; Typhoid Fever; Niño; Child; Alotipos de Inmunoglobulinas; Immunoglobulin Allotypes; https://id.nlm.nih.gov/mesh/D000293; https://id.nlm.nih.gov/mesh/D000704; https://id.nlm.nih.gov/mesh/D016022; https://id.nlm.nih.gov/mesh/D014435; https://id.nlm.nih.gov/mesh/D002648; https://id.nlm.nih.gov/mesh/D007126
• Rights: openAccess
• License: http://creativecommons.org/licenses/by-nc-sa/2.5/co/