Biological evaluation of aromatic compounds as B-Lactamase inhibitors

ABSTRACT: The appearance of bacterial resitance due to β-lactamase enzyme is frequent in Colombia and it has important consequences in term of morbidity and mortality. The inhibitory evaluation of the β-lactamase enzyme of 5 compounds gave as a result more powerful compounds than clavulanic acid. The more active chalcones establish hydrogen bonds with Ser, Tyr and Lys amino acids, the high number of hydrogen bonds between the compound and the amino acid increases the affinity and the inhibitory activity. In accordance with the results, the compounds might inhibit irreversibly the β-lactamase enzyme.

• Autores: Arango Acosta, Gabriel Jaime; Jaramillo Flórez, María Consuelo; Mora Arango, Cristina Lucía; Vélez, Luis Esteban; Quijano Tobón, Jairo
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2006
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/38198
• Acceso en línea: https://hdl.handle.net/10495/38198
• Palabra clave: beta-Lactamasas; beta-Lactamases; Ácido Clavulánico; Clavulanic Acid; Inhibidores Enzimáticos; Enzyme Inhibitors; Amoxicilina; Amoxicillin; Chalcona; Chalcone; https://id.nlm.nih.gov/mesh/D001618; https://id.nlm.nih.gov/mesh/D019818; https://id.nlm.nih.gov/mesh/D004791; https://id.nlm.nih.gov/mesh/D000658; https://id.nlm.nih.gov/mesh/D002599
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-nd/4.0/