Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon
ABSTRACT: Mango pulp contains ascorbic acid, carotenoids, polyphenols, terpenoids and fiber which are healthy and could protect against colon cancer. The aim of this study was to evaluate the antiproliferative and preventive capacity of an aqueous extract of Mangifera indica cv. Azúcar on a human co...
- Autores:
-
Corrales Bernal, Andrea
Urango Marchena, Luz Amparo
Rojano, Benjamín Alberto
Maldonado Celis, María Elena
- Tipo de recurso:
- Article of investigation
- Fecha de publicación:
- 2014
- Institución:
- Universidad de Antioquia
- Repositorio:
- Repositorio UdeA
- Idioma:
- spa
- OAI Identifier:
- oai:bibliotecadigital.udea.edu.co:10495/12035
- Acceso en línea:
- http://hdl.handle.net/10495/12035
- Palabra clave:
- Mangifera indica
Mangifera indica
Fitoquímicos
Phytochemicals
Cáncer de colon
Colon cancer
Quimioprevención
Chemoprevention
- Rights
- openAccess
- License
- https://creativecommons.org/licenses/by-nc/4.0/
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Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon |
| dc.title.translated.spa.fl_str_mv |
In vitro and in vivo effects of mango pulp (Mangifera indica cv. Azucar) in colon carcinogenesis |
| title |
Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon |
| spellingShingle |
Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon Mangifera indica Mangifera indica Fitoquímicos Phytochemicals Cáncer de colon Colon cancer Quimioprevención Chemoprevention |
| title_short |
Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon |
| title_full |
Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon |
| title_fullStr |
Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon |
| title_full_unstemmed |
Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon |
| title_sort |
Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon |
| dc.creator.fl_str_mv |
Corrales Bernal, Andrea Urango Marchena, Luz Amparo Rojano, Benjamín Alberto Maldonado Celis, María Elena |
| dc.contributor.author.none.fl_str_mv |
Corrales Bernal, Andrea Urango Marchena, Luz Amparo Rojano, Benjamín Alberto Maldonado Celis, María Elena |
| dc.contributor.researchgroup.spa.fl_str_mv |
Impacto de Componentes Alimentarios en la Salud |
| dc.subject.none.fl_str_mv |
Mangifera indica Mangifera indica Fitoquímicos Phytochemicals Cáncer de colon Colon cancer Quimioprevención Chemoprevention |
| topic |
Mangifera indica Mangifera indica Fitoquímicos Phytochemicals Cáncer de colon Colon cancer Quimioprevención Chemoprevention |
| description |
ABSTRACT: Mango pulp contains ascorbic acid, carotenoids, polyphenols, terpenoids and fiber which are healthy and could protect against colon cancer. The aim of this study was to evaluate the antiproliferative and preventive capacity of an aqueous extract of Mangifera indica cv. Azúcar on a human colon adenocarcinoma cell line (SW480) and in a rodent model of colorectal cancer, respectively. The content of total phenolics, flavonoids and carotenoids were also analyzed in the extract. SW480 cell growth was inhibited in a dose and time dependent manner by 22.3% after a 72h exposure to the extract (200 μg/ mL). Colon carcinogenesis was initiated in Balb/c mice by two intra-peritoneal injections of azoxymethane (AOM) at the third and fourth week of giving mango in drinking water (0.3%, 0.6%, 1.25%). After 10 weeks of treatment, in the colon of mice receiving 0.3% mango, aberrant crypt foci formation was inhibited more than 60% (p=0,05) and the inhibition was dose-dependent when compared with controls receiving water. These results show that mango pulp, a natural food, non toxic, part of human being diet, contains bioactive compounds able to reduce growth of tumor cells and to prevent the appearance of precancerous lesions in colon during carcinogenesis initiation. |
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2014 |
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2014 |
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2019-09-27T17:28:32Z |
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2019-09-27T17:28:32Z |
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Artículo de investigación |
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Corrales-Bernal A, Urango-Marchena L, Rojano B, Maldonado-Celis M. Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon. Archivos Latinoamericanos de Nutrición. 2014; 64(1): 16-23 |
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0004-0622 |
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http://hdl.handle.net/10495/12035 |
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2309-5806 |
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Corrales-Bernal A, Urango-Marchena L, Rojano B, Maldonado-Celis M. Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon. Archivos Latinoamericanos de Nutrición. 2014; 64(1): 16-23 0004-0622 2309-5806 |
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spa |
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Arch. Latinoam. Nutr. |
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Corrales Bernal, AndreaUrango Marchena, Luz AmparoRojano, Benjamín AlbertoMaldonado Celis, María ElenaImpacto de Componentes Alimentarios en la Salud2019-09-27T17:28:32Z2019-09-27T17:28:32Z2014Corrales-Bernal A, Urango-Marchena L, Rojano B, Maldonado-Celis M. Efectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colon. Archivos Latinoamericanos de Nutrición. 2014; 64(1): 16-230004-0622http://hdl.handle.net/10495/120352309-5806ABSTRACT: Mango pulp contains ascorbic acid, carotenoids, polyphenols, terpenoids and fiber which are healthy and could protect against colon cancer. The aim of this study was to evaluate the antiproliferative and preventive capacity of an aqueous extract of Mangifera indica cv. Azúcar on a human colon adenocarcinoma cell line (SW480) and in a rodent model of colorectal cancer, respectively. The content of total phenolics, flavonoids and carotenoids were also analyzed in the extract. SW480 cell growth was inhibited in a dose and time dependent manner by 22.3% after a 72h exposure to the extract (200 μg/ mL). Colon carcinogenesis was initiated in Balb/c mice by two intra-peritoneal injections of azoxymethane (AOM) at the third and fourth week of giving mango in drinking water (0.3%, 0.6%, 1.25%). After 10 weeks of treatment, in the colon of mice receiving 0.3% mango, aberrant crypt foci formation was inhibited more than 60% (p=0,05) and the inhibition was dose-dependent when compared with controls receiving water. These results show that mango pulp, a natural food, non toxic, part of human being diet, contains bioactive compounds able to reduce growth of tumor cells and to prevent the appearance of precancerous lesions in colon during carcinogenesis initiation.RESUMEN: La porción comestible del mango contiene ácido ascórbico, carotenoides, polifenoles, terpenoides y fibra que tienen efectos protectores para la salud, y posiblemente contra el desarrollo de cáncer de colon (CCO). El objetivo de este estudio fue evaluar la capacidad antiproliferativa en células de adenocarcinoma de colon (SW480) y preventiva en un modelo in vivo de CCO de un extracto acuoso de Mangifera indica cv. Azúcar. El contenido de fenoles totales, flavonoides y carotenoides también fue analizado. El extracto inhibió el crecimiento de las células SW480 en forma dosis-tiempo-dependiente hasta 22,3% luego de 72h de exposición al extracto (200 μg/mL). La carcinogénesis en el colon de ratones Balb/c fue inducida mediante dos inyecciones intraperitoneales de azoximetano (AOM) a la tercera y cuarta semana de haber iniciado el suministro de mango en el líquido de bebida (0,3%, 0,6%, 1,25%). Después de 10 semanas de tratamiento se observó inhibición dosis-dependiente de la formación de focos de criptas aberrantes (FCA); 0,3% de mango inhibió más del 60% de FCA (p=0,05) comparado con los controles que recibieron agua. Estos resultados muestran que la pulpa del mango de azúcar, un alimento natural, no tóxico, que forma parte de la dieta del ser humano contiene compuestos bioactivos capaces de reducir el crecimiento de células tumorales y prevenir la aparición de las lesiones precancerosas en colon durante el inicio de la carcinogénesis.application/pdfspaSociedad Latinoamericana de NutriciónCaracas, Venezuelahttps://creativecommons.org/licenses/by-nc/4.0/https://creativecommons.org/licenses/by-nc/2.5/co/Atribución-NoComercial 2.5 Colombia (CC BY-NC 2.5 CO)info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Mangifera indicaMangifera indicaFitoquímicosPhytochemicalsCáncer de colonColon cancerQuimioprevenciónChemopreventionEfectos in vitro e in vivo de la pulpa de mango (Mangifera indica cv. Azúcar) en la carcinogénesis de colonIn vitro and in vivo effects of mango pulp (Mangifera indica cv. Azucar) in colon carcinogenesisArtículo de investigaciónhttp://purl.org/coar/resource_type/c_2df8fbb1https://purl.org/redcol/resource_type/ARThttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArch. Latinoam. 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