OM-85 BV in pediatric recurrent respiratory tract infections: a cost-utility analysis

ABSTRACT: Background: Despite the growing evidence on efficacy, little is known regarding the cost-utility of Vaxom/Imocur (OM-85 BV) supplementation to decrease the probability of recurrent respiratory tract infections in OM-85 BV to reduce the incidence of recurrent respiratory tract infections in children. Methods: A decision tree model was used to estimate the cost and quality-adjusted life-years (QALYs) of OM-85 BV in a patient aged 1-6 with a history of recurrent respiratory tract infections. Multiple sensitivity analyses were conducted to evaluate the robustness of the model. Cost-effectiveness was evaluated using the willingness-to-pay defined for Colombia of US$5180 per QALY. The time horizon defined was six months. Costs were estimated from a societal perspective. Results: The expected annual cost per patient with OM-85 BV was US$843 and with placebo was US$1167. The QALYs per person estimated with OM-85 BV was 0.91 and with placebo was 0.89. Conclusion: In conclusion, our study shows that OM-85 BV is a cost-effective strategy to reduce the incidence of recurrent respiratory tract infections in children. Our study provides evidence that should be used by decision-makers to improve clinical practice guidelines.

• Autores: Buendía Rodríguez, Jefferson Antonio; Lindarte Rincón, Erika Fernanda; Guerrero Patiño, Diana
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2022
• Institución: Universidad de Antioquia
• Repositorio: Repositorio UdeA
• Idioma: eng
• OAI Identifier: oai:bibliotecadigital.udea.edu.co:10495/45374
• Acceso en línea: https://hdl.handle.net/10495/45374
• Palabra clave: Niño; Child; Colombia; Análisis Costo-Beneficio; Cost-Benefit Analysis; Infecciones del Tracto Respiratorio; Respiratory Tract Infections; Economía y Organizaciones para la Atención de la Salud; Health Care Economics and Organizations; Corticoesteroides; Adrenal Cortex Hormones; https://id.nlm.nih.gov/mesh/D002648; https://id.nlm.nih.gov/mesh/D003105; https://id.nlm.nih.gov/mesh/D003362; http://id.nlm.nih.gov/mesh/D012141; https://id.nlm.nih.gov/mesh/D004472; https://id.nlm.nih.gov/mesh/D000305
• Rights: openAccess
• License: http://creativecommons.org/licenses/by/2.5/co/